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Springer电子图书(1)	NATURE电子期刊(1)	ACS电子期刊(4)
SpringerLink电子期刊(20)	Elsevier电子期刊(24)

在“Elsevier电子期刊”中，命中：24条，耗时：0.0430084 秒

在所有数据库中总计命中：50条

1.Simultaneous Inhibition of PI3Kδ and PI3Kα Induces ABC-DLBCL Regression by Blocking BCR-Dependent and -Independent Activation of NF-κB and AKT

作者：Juliane Paul¹ ; ⁵ ; Maurice Soujon¹ ; ⁵ ; Antje M. Wengner¹ ; Sabine Zitzmann-Kolbe¹ ; Andrea Sturz¹ ; Katja Haike¹ ; Koh Hui Keng Magdalene² ; Sze Huey Tan³ ; Martin Lange¹ ; Soo Yong Tan² ; ⁶ ; Dominik Mumberg¹ ; Soon Thye Lim⁴ ; Karl Ziegelbauer¹ ; Ningshu Liu¹ ; ^{ningshu.liu@bayer.com}

关键词：PI3Kα ; PI3Kδ ; NF-κB ; BCR ; MYD88 ; CARD11 ; DLBCL ; follicular lymphoma ; ibrutinib-resistance ; copanlisib

刊名：Cancer Cell

出版年：2017

2.Identification of allosteric binding sites for PI3Kα oncogenic mutant specific inhibitor design

作者：Michelle S. Miller^a ; Sweta Maheshwari^b ; Fiona M. McRobb^c ; Kenneth W. Kinzler^d ; L. Mario Amzel^b ; Bert Vogelstein^d ; Sandra B. Gabelli^a ; ^b ; ^e ; ^{gabelli@jhmi.edu}

关键词：PIK3CA ; PI3K ; PIP2 ; PIP3 ; Fragment-based drug discovery

刊名：Bioorganic & Medicinal Chemistry

出版年：2017

3.Discovery of triazole aminopyrazines as a highly potent and selective series of PI3Kδ inhibitors

作者：Ina Terstiege^a ; ^{Ina.Terstiege@astrazeneca.com} ; Matthew Perry^a ; Jens Petersen^b ; Christian Tyrchan^a ; Tor Svensson^a ; Helena Lindmark^b ; Linda Ö ; ster^b

关键词：Phosphoinositide 3-kinase ; PI3Kδ inhibitor ; Aminopyrazine ; Inflammation

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2017

4.Discovery of a series of N-(5-(quinolin-6-yl)pyridin-3-yl)benzenesulfonamides as PI3K/mTOR dual inhibitors

作者：Jiankang Zhang^b ; Xiaoqing Lv^a ; ^{lxqd1@126.com} ; Xiaodong Ma^c ; Yongzhou Hu^d

关键词：PI3K ; mTOR ; Cancer ; Inhibitor

刊名：European Journal of Medicinal Chemistry

出版年：2017

5.Computer-aided design, synthesis, and biological evaluation of new indole-2-carboxamide derivatives as PI3Kα/EGFR inhibitors

作者：Kamal Sweidan^a ; ^{k.sweidan@ju.edu.jo" class="auth_mail" title="E-mail the corresponding author} ; ^{kamal_sweidan@hotmail.com" class="auth_mail" title="E-mail the corresponding author} ; Dima A. Sabbah^b ; ^{dima.sabbah@zuj.edu.jo" class="auth_mail" title="E-mail the corresponding author} ; ^{dima_sabbah@yahoo.com" class="auth_mail" title="E-mail the corresponding author} ; Sanaa Bardaweel^c ; Khadeja Abu Dush^a ; Ghassan Abu Sheikha^b ; Mohammad S. Mubarak^a

关键词：PI3Kα ; EGFR ; HCT116 ; MDA231 ; Docking

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

6.Design, synthesis, biological evaluation and docking studies of novel 2-substituted-4-morpholino-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidine derivatives as dual PI3Kα/mTOR inhibitors

作者：Fei Lei^a ; ¹ ; Chengyu Sun^a ; ¹ ; Shan Xu^a ; Qinqin Wang^a ; Yiqiang OuYang^a ; Chen Chen^a ; Hui Xia^a ; Linxiao Wang^a ; Pengwu Zheng^a ; ^{zhengpw@126.com" class="auth_mail" title="E-mail the corresponding author} ; Wufu Zhu^a ; ^b ; ^{zhuwufu-1122@163.com" class="auth_mail" title="E-mail the corresponding author}

关键词：Thiopyrano[4 ; 3-d]pyrimidine ; Synthesis ; Docking ; PI3Kα/mTOR inhibitors

刊名：European Journal of Medicinal Chemistry

出版年：2016

7.Discovery of 1-(4-(5-(5-amino-6-(5-tert-butyl-1,3,4-oxadiazol-2-yl)pyrazin-2-yl)-1-ethyl-1,2,4-triazol-3-yl)piperidin-1-yl)-3-hydroxypropan-1-one (AZD8835): A potent and selective inhibitor of PI3Kα and PI3Kδ for the treatment of cancers

作者：Bernard Barlaam^b ; ^{bernard.barlaam2@astrazeneca.com" class="auth_mail" title="E-mail the corresponding author} ; Sabina Cosulich^b ; Bé ; né ; dicte Delouvrié ; ^a ; Rebecca Ellston^b ; Martina Fitzek^b ; Hervé ; Germain^a ; Stephen Green^b ; Urs Hancox^b ; Craig S. Harris^a ; ^&dagger ; ; Kevin Hudson^b ; Christine Lambert-van der Brempt^a ; Honorine Lebraud^a ; Franç ; oise Magnien^a ; Maryannick Lamorlette^a ; Antoine Le Griffon^a ; Ré ; my Morgentin^a ; ^&Dagger ; ; Gilles Ouvry^a ; ^&dagger ; ; Ken Page^b ; Georges Pasquet^a ; Urszula Polanska^b ; Linette Ruston^b ; Twana Saleh^a ; Michel Vautier^a ; Lara Ward^b

关键词：PI3Kα ; PI3Kδ ; Kinase ; PIK3CA mutation

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2015

8.PDK1-SGK1 Signaling Sustains AKT-Independent mTORC1 Activation and Confers Resistance to PI3Kα Inhibition

作者：Pau Castel¹ ; Haley Ellis¹ ; Ruzica Bago² ; Eneda Toska¹ ; Pedram Razavi¹ ; ³ ; F. Javier Carmona¹ ; Srinivasaraghavan Kannan⁴ ; Chandra S. Verma⁴ ; ⁵ ; ⁶ ; Maura Dickler³ ; Sarat Chandarlapaty¹ ; ³ ; Edi Brogi⁷ ; Dario R. Alessi² ; José ; Baselga¹ ; ³ ; ^{baselgaj@mskcc.org" class="auth_mail" title="E-mail the corresponding author} ; Maurizio Scaltriti¹ ; ⁷ ; ^{scaltrim@mskcc.org" class="auth_mail" title="E-mail the corresponding author}

刊名：Cancer Cell

出版年：2016

9.Synthesis and anticancer activity of novel 4-morpholino-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidine derivatives bearing chromone moiety

作者：Chengyu Sun^a ; ^d ; ^&dagger ; ; Chen Chen^a ; ^&dagger ; ; Shan Xu^a ; ^{Shanxu9891@126.com" class="auth_mail" title="E-mail the corresponding author} ; Jianqiang Wang^b ; Yan Zhu^c ; Dejia Kong^a ; Hong Tao^a ; Mengjia Jin^a ; Pengwu Zheng^a ; Wufu Zhu^a ; ^{zhuwufu-1122@163.com" class="auth_mail" title="E-mail the corresponding author}

关键词：Thiopyranopyrimidine ; Chromone ; Synthesis ; Docking ; mTOR ; PI3Kα ; Antitumor activity

刊名：Bioorganic & Medicinal Chemistry

出版年：2016

10.Thioflavones as novel neuroprotective agents

作者：Divyashree Ravishankar^a ; Giulia Corona^b ; ^&dagger ; ; Stephanie M. Hogan^a ; Jeremy P.E. Spencer^b ; Francesca Greco^a ; ^{f.greco@reading.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; Helen M.I. Osborn^a ; ^{h.m.i.osborn@reading.ac.uk" class="auth_mail" title="E-mail the corresponding author}

关键词：MTT ; 3-(4 ; 5-dimethylthiazol-2-yl)-2 ; 5-diphenyltetrazolium bromide ; DPPH ; 2 ; 2-diphenyl-1-picrylhydrazyl ; EDTA ; ethylenediaminetetraacetic acid ; ERK1/2 ; extracellular signal-regulated kinase ; mTOR ; mammalian target of rapamycin ; AMPKα ; 5&prime ; adenosine monophosphate-activated protein kinase ; GSK-3β ; glycogen synthase kinase-3β ; Bad ; Bcl-2-associated death promoter ; PRAS40 ; proline-rich Akt substrate of 40 ; kDa ; PI3K ; phosphatidylinositol-4 ; 5-bisphosphate-3-kinase ; BDNF ; brain-derived neurotr

刊名：Bioorganic & Medicinal Chemistry

出版年：2016

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