脊髓损伤的治疗原则及进展
摘要
<正>随着社会进步,交通、建筑及工矿企业等事业的迅速发展,以及地震等自然灾害和各种事故多发,脊髓损伤呈高发趋势,目前我国的发病率以北京市为统计范围,大约在60/106,明显高于发达国家〔1〕,且多见于青壮年男性,目前尚无非常有效的治疗措施。脊髓损伤严重者导致伤员死亡,
引文
[1]李建军,周红俊,洪毅,等.2002年北京市脊髓损伤发病率调查[J].中国康复理论与实践,2004,10(7):412-413.
[2]朱辉.重视脊柱脊髓损伤的围手术期研究[J].中华神经外科疾病研究杂志,2011,10(1):1-4.
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[4]CADOTTE D W,FEHLINGS M G.Spinal cord injury:a systematic review of current treatment options[J].Clin Orthop Relat Res,2011,469:732-741.
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[6]PARK K K,LIU K,HU Y,et al.Promoting axon regeneration in the adult CNS by modulation of the PTEN/mTOR pathway[J].Science,2008,322:963-966.
[7]ABE N,BORSON S H,GAMBELLO M J,et al.Mam-malian target of rapamycin(mTOR)activation increa-ses axonal growth capacity of injured peripheral nerves[J].J Biol Chem,2010,285:28034-28043.
[8]LIU K,LU Y,LEE J K,et al.PTEN deletion enhances the regenerative ability of adult corticospinal neurons[J].Nat Neurosci,2010,13:1075-1081.
[9]CHRISTIE K J,WEBBER C A,MARTINEZ J A,et al.PTEN inhibition to facilitate intrinsic regenerative outgrowth of adult peripheral axons[J].J Neurosci,2010,30:9306-9315.
[10]KURIMOTO T,YIN Y,OMURA K,et al.Long-distance axon regeneration in the mature optic nerve:contributions of oncomodulin,cAMP,and pten gene deletion[J].J Neurosci,2010,30:15654-15663.
[11]ZAHIR T,NOMURA H,GUO X D,et al.Bioengi-neering neural stem/progenitor cell-coated tubes for spinal cord injury repair[J].Cell Transplant,2008,17:245-254.
[12]GUO X D,ZAHIR T,SHOICHET M S,et al.The effect of growth factors and soluble Nogo66receptor protein on transplanted neural stem/progenitor survival and axonal regeneration after complete transection of rat spinal cord[J].Cell Transplantation,2011.[Accepted].
[13]YUAN Q,GUO X D,ZHENG Q X,et al.Bioinspired growth of hydroxyapatite nanocrystals on PLGA-(PEG-ASP)n scaffolds modified with oligopeptide de-rived from BMP-2[J].Key engineering materials,2007,334/335:1261-1264.
[14]YUAN Q,LU H W,TANG S,et al.Ectopic bone formation in vivo induced by a novel synthetic peptide de-rived from BMP-2using porous collagen scaffolds[J].J WUHAN UNIV TECHNOL,2007,22:701-705.
[15]LIN Z Y,DUAN Z X,GUO X D,et al.Bone induction by biomimetic PLGA-(PEG-ASP)n copolymer loaded with a novel synthetic BMP-2-related peptide in vitro and in vivo[J].J Control Release,2010,144:190-195.
[16]GUO X D,YUAN Q,ZHENG Q X,et al.Biologically inspired self-assembling synthesis of bone-like nano-hydroxyapatite/PLGA-(PEG-ASP)n composite:A new biomimetic bone tissue engineering scaffold material[J].J WUHAN UNIV TECHNOL,2005,20:S234-237.
[17]GUO X D,ZHENG Q X,KULBATSKI I,et al.Bone regeneration with active angiogenesis by basic fibro-blast growth factor gene transfected mesenchymal stem cells seeded on porous beta-TCP ceramic scaf-folds[J].Biomed Mater,2006,1:93-99.
[18]CHENG H,CAO Y,OLSON L.Spinal cord repair in adult paraplegic rats:partial restoration of hind limb function[J].Science,1996,273:510-513.
[19]TADIE M,LIU S,ROBERT R,et al.Partial return of motor function in paralyzed legs after surgical bypass of the lesion site by nerve autografts three years after spinal cord injury[J].J Neurotrauma,2002,19:909-916.
[20]姜宗圆,王涛.健侧C7神经根移位术的研究进展[J].实用手外科杂志,2002,16(4):226-227.
[21]CAMPOS L,MENG Z,HU G,et al.Engineering novel spinal circuits to promote recovery after spinal injury[J].J Neurosci,2004,24:2090-2101.
[2]朱辉.重视脊柱脊髓损伤的围手术期研究[J].中华神经外科疾病研究杂志,2011,10(1):1-4.
[3]LAMMERTSE D P.Update on pharmaceutical trials in acute spinal cord injury[J].J Spinal Cord Med,2004,27:319-325.
[4]CADOTTE D W,FEHLINGS M G.Spinal cord injury:a systematic review of current treatment options[J].Clin Orthop Relat Res,2011,469:732-741.
[5]徐伟刚,徐和平,陶恒沂,等.脊髓损伤的高压氧治疗[J].中华航海医学与高气压医学杂志,2001,8(2):113-116.
[6]PARK K K,LIU K,HU Y,et al.Promoting axon regeneration in the adult CNS by modulation of the PTEN/mTOR pathway[J].Science,2008,322:963-966.
[7]ABE N,BORSON S H,GAMBELLO M J,et al.Mam-malian target of rapamycin(mTOR)activation increa-ses axonal growth capacity of injured peripheral nerves[J].J Biol Chem,2010,285:28034-28043.
[8]LIU K,LU Y,LEE J K,et al.PTEN deletion enhances the regenerative ability of adult corticospinal neurons[J].Nat Neurosci,2010,13:1075-1081.
[9]CHRISTIE K J,WEBBER C A,MARTINEZ J A,et al.PTEN inhibition to facilitate intrinsic regenerative outgrowth of adult peripheral axons[J].J Neurosci,2010,30:9306-9315.
[10]KURIMOTO T,YIN Y,OMURA K,et al.Long-distance axon regeneration in the mature optic nerve:contributions of oncomodulin,cAMP,and pten gene deletion[J].J Neurosci,2010,30:15654-15663.
[11]ZAHIR T,NOMURA H,GUO X D,et al.Bioengi-neering neural stem/progenitor cell-coated tubes for spinal cord injury repair[J].Cell Transplant,2008,17:245-254.
[12]GUO X D,ZAHIR T,SHOICHET M S,et al.The effect of growth factors and soluble Nogo66receptor protein on transplanted neural stem/progenitor survival and axonal regeneration after complete transection of rat spinal cord[J].Cell Transplantation,2011.[Accepted].
[13]YUAN Q,GUO X D,ZHENG Q X,et al.Bioinspired growth of hydroxyapatite nanocrystals on PLGA-(PEG-ASP)n scaffolds modified with oligopeptide de-rived from BMP-2[J].Key engineering materials,2007,334/335:1261-1264.
[14]YUAN Q,LU H W,TANG S,et al.Ectopic bone formation in vivo induced by a novel synthetic peptide de-rived from BMP-2using porous collagen scaffolds[J].J WUHAN UNIV TECHNOL,2007,22:701-705.
[15]LIN Z Y,DUAN Z X,GUO X D,et al.Bone induction by biomimetic PLGA-(PEG-ASP)n copolymer loaded with a novel synthetic BMP-2-related peptide in vitro and in vivo[J].J Control Release,2010,144:190-195.
[16]GUO X D,YUAN Q,ZHENG Q X,et al.Biologically inspired self-assembling synthesis of bone-like nano-hydroxyapatite/PLGA-(PEG-ASP)n composite:A new biomimetic bone tissue engineering scaffold material[J].J WUHAN UNIV TECHNOL,2005,20:S234-237.
[17]GUO X D,ZHENG Q X,KULBATSKI I,et al.Bone regeneration with active angiogenesis by basic fibro-blast growth factor gene transfected mesenchymal stem cells seeded on porous beta-TCP ceramic scaf-folds[J].Biomed Mater,2006,1:93-99.
[18]CHENG H,CAO Y,OLSON L.Spinal cord repair in adult paraplegic rats:partial restoration of hind limb function[J].Science,1996,273:510-513.
[19]TADIE M,LIU S,ROBERT R,et al.Partial return of motor function in paralyzed legs after surgical bypass of the lesion site by nerve autografts three years after spinal cord injury[J].J Neurotrauma,2002,19:909-916.
[20]姜宗圆,王涛.健侧C7神经根移位术的研究进展[J].实用手外科杂志,2002,16(4):226-227.
[21]CAMPOS L,MENG Z,HU G,et al.Engineering novel spinal circuits to promote recovery after spinal injury[J].J Neurosci,2004,24:2090-2101.
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