颅脑伤合并复合伤动物模型的研究进展
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摘要
<正>近年来由于交通事故伤和坠落伤以及自然灾害的加剧(地震、海啸、泥石流等),创伤性颅脑损伤已成为人类高致死率和高致残率的重要原因之一和当今威胁人类生命健康的重要疾患之一[1,2]。通过临床工作发现,在外伤中有相当一部分
引文
1陈隆益,唐健,黄光富,等.地震所致颅脑创伤265例流行病学及临床分析[J].西部医学,2009,21(10):1699-1701.
2王娜,李林.创伤性脑损伤动物模型的研究进展[J].中国康复理论与实践,2009,15(10):905-907.
3杨运发,林博川,李远辉,等.兔骨折合并脑外伤模型血清对鼠骨折愈合影响的实验研究[J].临床医学工程,2010,17(11):25-27.
4 Wang L,Yuan JS,Zhang HX,et al.Effect of leptin on bonemetabolism in rat model of traumatic brain injury and femoral fracture[J].Chin J Traumatol,2011,14(1):7-13.
5孙良智,张柳,王守君,等.大鼠股骨骨折合并脑损伤骨折愈合过程中胰岛素样生长因子I在血清和骨痂中的表达[J].中国临床康复,2006,10(40):60-62.
6 Pietrapiana P,Tamietto M,Torrini G,et al.Role of premorbid factorsin predicting safe return to driving after severe TBI[J].Brain Inj,2005,19(3):197-211.
7马维,牛彦平,张华,等.合并脑损伤大鼠骨折愈合过程中转化生长因子β1血清含量及在骨折位点的表达[J].中国临床康复,2006,10(42):88-91.
8 Qin XS,Jin KH,Ding BK,et al.Effects of extract of Ginkgo bilobawith venlafaxine on brain injury in a rat model of depression[J].ChinMed J(Engl),2005,118(5):391-397.
9罗同青,李兵.骨折合并脑损伤动物模型研究进展[J].医学综述,2008,14(8):1130-1132.
10罗同青,李兵,胡朝辉,等.骨折并侧方液压脑损伤模型的建立[J].中国组织工程研究与临床康复,2008,12(37):7272-7276.
11顾兵,金建波,孟玮,等.创伤性脑损伤动物模型及其实验治疗学应用[J].中国药理学通报,2010,26(3):285-289.
12陈云强,孙天胜,刘佳,等.股骨干骨折合并脑损伤后大鼠多器官功能损害的生化指标观察[J].中国骨伤,2011,24(5):404-406.
13 Chhen YQ,Sun TS,Liu J.Observation on biochemical indicator ofmultiple organ functional dysfunction after femoral shaft fracturecombined with brain injury in rats[J].Zhongguo Gu Shang,2011,24(5):404-406.
14陈振强,刘国英.大鼠颅脑损伤合并四肢骨折加速愈合的原因研究[J].湖南中医药大学学报,2010,30(4):54-57.
15 Maegele M,Riess P,Sauerland S,et al.Characterization of a new ratmodel of experimental combined neurotrauma[J].Shock,2005,23(5):476-481.
16 Lasanianos NG,Kanakaris NK,Giannoudis PV.Intramedullary nailingas a'second hit'phenomenon in experimental research:lessons learnedand future directions[J].Clin Orthop Relat Res,2010,468(9):2514-2529.
17罗伟,李雪元,李甲,等.小型猪脑外伤急性颅内高压并失血性休克模型的建立[J].上海交通大学学报:医学版,2010,30(9):1106-1110.
18 Kerby JD,Sainz JG,Zhang FY,et al.Resuscitation from hemorrhagicshock with HBOC-201 in the setting of traumatic brain injury[J].Shock,2007,27(6):652-656.
19 Rosenthal G,Morabito D,Cohen M,et al.Use of hemoglobin-basedoxygen-carrying solution-201 to improve resuscitation parameters andprevent secondary brain injury in a swine model of traumatic brain injuryand hemorrhage:laboratory investigation[J].J Neurosurg,2008,108(3):575-587.
20崔红.密闭舱室大鼠爆炸伤合并失血性休克特点与容量复苏的研究[D].第三军医大学大坪医院野战外科研究所,2010:51-55.
2王娜,李林.创伤性脑损伤动物模型的研究进展[J].中国康复理论与实践,2009,15(10):905-907.
3杨运发,林博川,李远辉,等.兔骨折合并脑外伤模型血清对鼠骨折愈合影响的实验研究[J].临床医学工程,2010,17(11):25-27.
4 Wang L,Yuan JS,Zhang HX,et al.Effect of leptin on bonemetabolism in rat model of traumatic brain injury and femoral fracture[J].Chin J Traumatol,2011,14(1):7-13.
5孙良智,张柳,王守君,等.大鼠股骨骨折合并脑损伤骨折愈合过程中胰岛素样生长因子I在血清和骨痂中的表达[J].中国临床康复,2006,10(40):60-62.
6 Pietrapiana P,Tamietto M,Torrini G,et al.Role of premorbid factorsin predicting safe return to driving after severe TBI[J].Brain Inj,2005,19(3):197-211.
7马维,牛彦平,张华,等.合并脑损伤大鼠骨折愈合过程中转化生长因子β1血清含量及在骨折位点的表达[J].中国临床康复,2006,10(42):88-91.
8 Qin XS,Jin KH,Ding BK,et al.Effects of extract of Ginkgo bilobawith venlafaxine on brain injury in a rat model of depression[J].ChinMed J(Engl),2005,118(5):391-397.
9罗同青,李兵.骨折合并脑损伤动物模型研究进展[J].医学综述,2008,14(8):1130-1132.
10罗同青,李兵,胡朝辉,等.骨折并侧方液压脑损伤模型的建立[J].中国组织工程研究与临床康复,2008,12(37):7272-7276.
11顾兵,金建波,孟玮,等.创伤性脑损伤动物模型及其实验治疗学应用[J].中国药理学通报,2010,26(3):285-289.
12陈云强,孙天胜,刘佳,等.股骨干骨折合并脑损伤后大鼠多器官功能损害的生化指标观察[J].中国骨伤,2011,24(5):404-406.
13 Chhen YQ,Sun TS,Liu J.Observation on biochemical indicator ofmultiple organ functional dysfunction after femoral shaft fracturecombined with brain injury in rats[J].Zhongguo Gu Shang,2011,24(5):404-406.
14陈振强,刘国英.大鼠颅脑损伤合并四肢骨折加速愈合的原因研究[J].湖南中医药大学学报,2010,30(4):54-57.
15 Maegele M,Riess P,Sauerland S,et al.Characterization of a new ratmodel of experimental combined neurotrauma[J].Shock,2005,23(5):476-481.
16 Lasanianos NG,Kanakaris NK,Giannoudis PV.Intramedullary nailingas a'second hit'phenomenon in experimental research:lessons learnedand future directions[J].Clin Orthop Relat Res,2010,468(9):2514-2529.
17罗伟,李雪元,李甲,等.小型猪脑外伤急性颅内高压并失血性休克模型的建立[J].上海交通大学学报:医学版,2010,30(9):1106-1110.
18 Kerby JD,Sainz JG,Zhang FY,et al.Resuscitation from hemorrhagicshock with HBOC-201 in the setting of traumatic brain injury[J].Shock,2007,27(6):652-656.
19 Rosenthal G,Morabito D,Cohen M,et al.Use of hemoglobin-basedoxygen-carrying solution-201 to improve resuscitation parameters andprevent secondary brain injury in a swine model of traumatic brain injuryand hemorrhage:laboratory investigation[J].J Neurosurg,2008,108(3):575-587.
20崔红.密闭舱室大鼠爆炸伤合并失血性休克特点与容量复苏的研究[D].第三军医大学大坪医院野战外科研究所,2010:51-55.
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