双歧杆菌三联活菌片治疗地震灾区(汶川)腹泻型肠易激综合征患者的多中心临床研究
|
摘要
目的观察双歧杆菌三联活菌片对地震灾区(汶川)腹泻型肠易激综合征(IBS)患者的疗效和安全性。方法采用多中心、随机、开放的临床试验,根据我们进行的流行病学调查结果,对符合罗马Ⅱ和罗马Ⅲ标准的所有患者共945人,再用罗马Ⅲ标准进一步对其诊断和分型,有172例为腹泻型IBS,84例自愿口服双歧杆菌乳杆菌三联活菌片。记录并量化治疗前、后患者的症状和大便性状,记录治疗中的不良事件。结果口服双歧杆菌乳杆菌三联活菌片后,患者的大便性状改变评分明显好转,改善率达90.9%,而腹痛症状(时间、次数)评分无显著改变。不良事件3例,与服药无关。结论双歧杆菌三联活菌片可明显改善地震灾区(汶川)肠易激综合征患者(腹泻型)的大便性状症状,且安全性高、耐受性好。
Objective To assess the efficacy and safety of live combined bifidobacterium and lactobacillus tablets in patients with diarrhea-predominant IBS in earthquake area(Wenchuan).Methods A total of 84 patients were received live combined bifidobacterium and lactobacillus tablets.IBS-related symptoms and stool consistency were recorded at the beginning and the end of the treatment phase.The adverse events were recorded during the treatment too.Results The rate of improvement of IBS-related symptoms and stool consistency was 90.9% after the treatment,while the abdominal pain was not improved significantly.There were 3 adverse events which had no truck with the treatment.Conclusion Live combined bifidobacterium and lactobacillus tablets can improve the IBS-related symptoms and stool consistency significantly with highly tolerance and safety.
Objective To assess the efficacy and safety of live combined bifidobacterium and lactobacillus tablets in patients with diarrhea-predominant IBS in earthquake area(Wenchuan).Methods A total of 84 patients were received live combined bifidobacterium and lactobacillus tablets.IBS-related symptoms and stool consistency were recorded at the beginning and the end of the treatment phase.The adverse events were recorded during the treatment too.Results The rate of improvement of IBS-related symptoms and stool consistency was 90.9% after the treatment,while the abdominal pain was not improved significantly.There were 3 adverse events which had no truck with the treatment.Conclusion Live combined bifidobacterium and lactobacillus tablets can improve the IBS-related symptoms and stool consistency significantly with highly tolerance and safety.
引文
[1]上海市双歧三联活菌协作组.双歧三联活菌治疗肠易激综合征的临床多中心研究[J].上海医学,2004,24(10):728～731
[2]胡品津,方秀才.肠易激综合征诊断和治疗[M].第1版.北京:科学出版社,2009,21～22;37～38;41～71
[3]Aragon G,Graham DB,Borum M,et al.Probiotic therapy for irritablebowel syndrome.Gastroenterol Hepatol(N Y)[J].2010,6(1):39～44
[4]王春江,陈科全,刘思德.双歧三联活菌制剂(培菲康)对老年人以便秘为主的肠易激综合症疗效观察[J].现代消化及介入诊疗,2009,14(3):199～200
[5]郑仕诚,付万朝,董晓薇,等.地震灾区(汶川)中学生肠易激综合征患者的焦虑性情绪障碍状况分析[J].四川医学,2010,31(7):876～878
[2]胡品津,方秀才.肠易激综合征诊断和治疗[M].第1版.北京:科学出版社,2009,21～22;37～38;41～71
[3]Aragon G,Graham DB,Borum M,et al.Probiotic therapy for irritablebowel syndrome.Gastroenterol Hepatol(N Y)[J].2010,6(1):39～44
[4]王春江,陈科全,刘思德.双歧三联活菌制剂(培菲康)对老年人以便秘为主的肠易激综合症疗效观察[J].现代消化及介入诊疗,2009,14(3):199～200
[5]郑仕诚,付万朝,董晓薇,等.地震灾区(汶川)中学生肠易激综合征患者的焦虑性情绪障碍状况分析[J].四川医学,2010,31(7):876～878
版权所有：© 2023 中国地质图书馆 中国地质调查局地学文献中心