双歧三联活菌片与蒙脱石散联合治疗腹泻患儿对血清免疫蛋白、血锌水平的影响
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摘要
目的:腹泻是儿科常见疾病,其治疗方式多是肠道保护与菌群调节相结合,本文采用双歧三联活菌片联合蒙脱石散治疗腹泻患儿,观察其对血清免疫蛋白、血锌水平的影响。方法:选取2017年6月1日-2018年6月1日笔者所在医院儿科腹泻患儿198例,密封信封法分为对照组和联合组,每组99例,对照组在基础治疗上予以蒙脱石散治疗,联合组在基础治疗上予以双歧三联活菌片联合蒙脱石散治疗,观察两组临床常见体征指标和症状缓解时间,比较其治疗前后免疫功能、肠道主要菌群和血锌的变化。结果:联合组血常规恢复时间、粪常规恢复时间、体温恢复时间、腹痛和呕吐缓解时间均早于对照组,差异均有统计学意义(t=15.95、14.12、13.07、18.74、20.86,P<0.05);治疗后,两组患儿免疫球蛋白A、免疫球蛋白G、CD4+、CD4+/CD8+均升高,CD8+均降低,且联合组各指标均优于对照组,差异均有统计学意义(P<0.05);治疗后,两组乳杆菌属、肠球菌属数量均升高,酵母样真菌均降低,且联合组菌群均优于对照组,差异均有统计学意义(P<0.05);治疗后,两组血锌水平均提高,且联合组高于对照组,差异均有统计学意义(P<0.05)。结论:双歧三联活菌片联合蒙脱石散能够促进患儿体征指标和临床症状的恢复,显著改善腹泻患儿血清免疫蛋白水平,提升血锌,改善肠道菌群。
Objective: Diarrhea is a common disease in department of pediatrics, and its treatment regimen is mostly combination of intestinal protection and flora regulation. In this paper, Bifid Triple Viable Tablet combined with Montmorillonite Powder was used for children with diarrhea to observe the effects on serum immune protein and blood zinc levels. Method: A total of 198 children with diarrhea in department of pediatrics of our hospital from June 1, 2017 to June 1, 2018 were selected and divided into control group and combined group according to the sealed envelope method, with 99 cases in each group. The control group was given Montmorillonite Powder on the basis of basic treatment, and the combined group was given Bifid Triple Viable Tablet combined with Montmorillonite Powder on the basis of basic treatment. The relief times of clinical common signs and symptoms were observed in the two groups, and the immune function, intestinal major flora and blood zinc were compared before and after treatment. Result: The recovery time of blood routine, fecal routine recovery, body temperature, abdominal pain and vomiting in the combined group were significantly earlier than those in the control group, the differences were statistically significant(t=15.95, 14.12, 13.07, 18.74, 20.86, P<0.05). After treatment, the immunoglobulin A, immunoglobulin G, CD4+, CD4+/CD8+ increased and CD8+ decreased in the two groups, and the indexes in the combined group were better than those in the control group, the differences were statistically significant(P<0.05). After treatment, the number of Lactobacillus and Enterococcus increased and the number of Yeast-like fungi decreased in the two groups, and the flora of the combined group was better than that of the control group, the differences were statistically significant(P<0.05). After treatment, the level of serum zinc in the two groups was increased, and the level of serum zinc in the combined group was higher than that in the control group, and the differences were statistically significant(P<0.05). Conclusion: Bifid Triple Viable Tablet combined with Montmorillonite Powder can promote the recovery of physical signs and clinical symptoms of children, significantly improve serum immune protein level, enhance blood zinc and improve intestinal flora in children with diarrhea.
Objective: Diarrhea is a common disease in department of pediatrics, and its treatment regimen is mostly combination of intestinal protection and flora regulation. In this paper, Bifid Triple Viable Tablet combined with Montmorillonite Powder was used for children with diarrhea to observe the effects on serum immune protein and blood zinc levels. Method: A total of 198 children with diarrhea in department of pediatrics of our hospital from June 1, 2017 to June 1, 2018 were selected and divided into control group and combined group according to the sealed envelope method, with 99 cases in each group. The control group was given Montmorillonite Powder on the basis of basic treatment, and the combined group was given Bifid Triple Viable Tablet combined with Montmorillonite Powder on the basis of basic treatment. The relief times of clinical common signs and symptoms were observed in the two groups, and the immune function, intestinal major flora and blood zinc were compared before and after treatment. Result: The recovery time of blood routine, fecal routine recovery, body temperature, abdominal pain and vomiting in the combined group were significantly earlier than those in the control group, the differences were statistically significant(t=15.95, 14.12, 13.07, 18.74, 20.86, P<0.05). After treatment, the immunoglobulin A, immunoglobulin G, CD4+, CD4+/CD8+ increased and CD8+ decreased in the two groups, and the indexes in the combined group were better than those in the control group, the differences were statistically significant(P<0.05). After treatment, the number of Lactobacillus and Enterococcus increased and the number of Yeast-like fungi decreased in the two groups, and the flora of the combined group was better than that of the control group, the differences were statistically significant(P<0.05). After treatment, the level of serum zinc in the two groups was increased, and the level of serum zinc in the combined group was higher than that in the control group, and the differences were statistically significant(P<0.05). Conclusion: Bifid Triple Viable Tablet combined with Montmorillonite Powder can promote the recovery of physical signs and clinical symptoms of children, significantly improve serum immune protein level, enhance blood zinc and improve intestinal flora in children with diarrhea.
引文
[1]张树忠,赵宏俊,张玉振,等.639例住院小儿腹泻治疗现状分析[J].实用临床医药杂志,2015,19(21):223-224.
[2]全国腹泻病防治学术研讨会组委会.中国腹泻病诊断治疗方案[J]中国实用儿科杂志,2011,13(7):381-383.
[3]沈哲,马良,章文华.微生态制剂对肝性脑病患者肠道菌群及血氨的影响[J].中华医院感染学杂志,2014,24(10):2505-2507.
[4]刘萍,董丽娜,韩轶,等.青少年肠道菌群特点分析[J].中国药物与临床,2015,15(12):1685-1688.
[5]房清文,李春艳.临床护理路径在小儿腹泻护理中的应用价值及临床效果[J].现代消化及介入诊疗,2016,21(1):158-160.
[6]柳树英,杨志华,原睿,等.基于“脾胃学说”探讨微生态制剂在小儿腹泻中的应用[J].西部中医药,2015,28(9):134-136.
[7]柴艳婷,邹海琼.中西医结合治疗小儿腹泻临床观察[J].现代中西医结合杂志,2014,23(5):516-517.
[8]陈颖,石明芳,曾嵘.双歧杆菌活菌联合蒙脱石散治疗小儿腹泻疗效观察[J].西部医学,2016,28(5):687-690.
[9] Wang Z H,Gao Q Y,Fang J Y.Meta-analysis of the efficacy and safety of Lactobacillus-containing and Bifidobacterium-containing probiotic compound preparation in Helicobacter pylori eradication therapy[J].Journal of Clinical Gastroenterology,2013,47(1):25-32.
[10]卢建华,刘晓律.双歧三联活菌片联合蒙脱石散治疗小儿腹泻疗效及对患儿免疫功能的影响[J].临床和实验医学杂志,2015,14(2):125-127.
[11]司梦冉,蔡君豪,王文奕,等.推拿与蒙脱石散治疗小儿腹泻效果比较的Meta分析[J].中国医药导报,2016,13(19):76-79.
[12]孙金平.探析双歧三联活菌片联合蒙脱石散治疗小儿腹泻的临床疗效及对患儿免疫功能的影响[J].中国继续医学教育,2016,8(35):172-173.
[13]王莹莹.双歧杆菌活菌联合蒙脱石散治疗小儿腹泻的效果观察[J].湖南中医药大学学报,2016,36(A01):470-471.
[14]刘慧,孙涛.肠道菌群失调的研究进展[J].医学综述,2014,20(3):468-471.
[15]马张杰,韦蓉,蒙丹华.腹泻儿童血清锌水平与腹泻病程及免疫水平的相关性研究[J].海南医学,2016,27(15):2444-2446.
[16]江红.双歧三联活菌片联合蒙脱石散治疗小儿腹泻疗效及对患儿免疫功能的影响[J].临床医学,2016,36(9):14-16.
[2]全国腹泻病防治学术研讨会组委会.中国腹泻病诊断治疗方案[J]中国实用儿科杂志,2011,13(7):381-383.
[3]沈哲,马良,章文华.微生态制剂对肝性脑病患者肠道菌群及血氨的影响[J].中华医院感染学杂志,2014,24(10):2505-2507.
[4]刘萍,董丽娜,韩轶,等.青少年肠道菌群特点分析[J].中国药物与临床,2015,15(12):1685-1688.
[5]房清文,李春艳.临床护理路径在小儿腹泻护理中的应用价值及临床效果[J].现代消化及介入诊疗,2016,21(1):158-160.
[6]柳树英,杨志华,原睿,等.基于“脾胃学说”探讨微生态制剂在小儿腹泻中的应用[J].西部中医药,2015,28(9):134-136.
[7]柴艳婷,邹海琼.中西医结合治疗小儿腹泻临床观察[J].现代中西医结合杂志,2014,23(5):516-517.
[8]陈颖,石明芳,曾嵘.双歧杆菌活菌联合蒙脱石散治疗小儿腹泻疗效观察[J].西部医学,2016,28(5):687-690.
[9] Wang Z H,Gao Q Y,Fang J Y.Meta-analysis of the efficacy and safety of Lactobacillus-containing and Bifidobacterium-containing probiotic compound preparation in Helicobacter pylori eradication therapy[J].Journal of Clinical Gastroenterology,2013,47(1):25-32.
[10]卢建华,刘晓律.双歧三联活菌片联合蒙脱石散治疗小儿腹泻疗效及对患儿免疫功能的影响[J].临床和实验医学杂志,2015,14(2):125-127.
[11]司梦冉,蔡君豪,王文奕,等.推拿与蒙脱石散治疗小儿腹泻效果比较的Meta分析[J].中国医药导报,2016,13(19):76-79.
[12]孙金平.探析双歧三联活菌片联合蒙脱石散治疗小儿腹泻的临床疗效及对患儿免疫功能的影响[J].中国继续医学教育,2016,8(35):172-173.
[13]王莹莹.双歧杆菌活菌联合蒙脱石散治疗小儿腹泻的效果观察[J].湖南中医药大学学报,2016,36(A01):470-471.
[14]刘慧,孙涛.肠道菌群失调的研究进展[J].医学综述,2014,20(3):468-471.
[15]马张杰,韦蓉,蒙丹华.腹泻儿童血清锌水平与腹泻病程及免疫水平的相关性研究[J].海南医学,2016,27(15):2444-2446.
[16]江红.双歧三联活菌片联合蒙脱石散治疗小儿腹泻疗效及对患儿免疫功能的影响[J].临床医学,2016,36(9):14-16.
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