基于高通量分析方法的长江干流重庆段抗生素种类特征及来源初探
|
摘要
采用高通量分析方法对长江干流重庆段11个流域断面、2个市政污水处理厂进水和6个养殖场废水的潜在抗生素进行筛查,并结合抗生素使用调查探讨其来源。结果表明,(1)共检出83种抗生素,其中流域内检出36种,污水处理厂和养殖场废水中检出70种;磺胺间甲氧嘧啶检出率最高,在流域水体和废水的检出率分别为91%和55%,喹诺酮类是检出抗生素的主要类型;(2)长江干流重庆段下游检出抗生素数量高于上游检出抗生素;(3)有20种抗生素可能由上游携带和重庆市内排放2种方式进入流域,7种抗生素可能由上游携带入境,9种抗生素可能由重庆市内排放引入长江。
A high throughput method was applied for screening potential antibiotics in water at 11 sections in the Yangtze River,in wastewater of two municipal sewage treatment plants,and in wastewater from six livestock farms in Chongqing City. A total of 83 antibiotics were identified in the samples,of which 36 were found in the Yangtze River and 70 were found in the wastewater of sewage treatment plants and livestock farms. Sulfamonomethoxine had the highest detection frequencies,with 91% in the Yangtze River water and 55% in the wastewater. Quinolones were the dominant antibiotics. The number of antibiotics identified in the Yangtze River was higher in water after running through Chongqing. There were 20 antibiotics that may be generated both from upstream input and discharge of Chongqing City,seven antibiotics that may occur before the river entering Chongqing,and nine antibiotics that may be introduced into the Yangtze River by Chongqing City.
A high throughput method was applied for screening potential antibiotics in water at 11 sections in the Yangtze River,in wastewater of two municipal sewage treatment plants,and in wastewater from six livestock farms in Chongqing City. A total of 83 antibiotics were identified in the samples,of which 36 were found in the Yangtze River and 70 were found in the wastewater of sewage treatment plants and livestock farms. Sulfamonomethoxine had the highest detection frequencies,with 91% in the Yangtze River water and 55% in the wastewater. Quinolones were the dominant antibiotics. The number of antibiotics identified in the Yangtze River was higher in water after running through Chongqing. There were 20 antibiotics that may be generated both from upstream input and discharge of Chongqing City,seven antibiotics that may occur before the river entering Chongqing,and nine antibiotics that may be introduced into the Yangtze River by Chongqing City.
引文
[1]闫先收．小清河流域典型抗生素分布、来源及风险评价[D]．济南:山东师范大学，2018:4-5Yan X S. Distribution,sources and risk evaluation of typical antibiotics in Xiaoqing River Basin[D]. Jinan:Shandong Normal University,2018:4-5(in Chinese)
[2]蒋晓霞．抗生素类药物在某典型性流域水环境中的分布特征[D]．深圳:深圳大学，2015:1-2Jiang X X. Distribution of typical antibotics in the aquatic environment of the River[D]. Shenzhen:Shenzhen University,2015:1-2(in Chinese)
[3]周志洪，赵建亮，魏晓东，等．珠江广州段水体抗生素的复合污染特征及其生态风险[J]．生态环境学报，2017,26(6):1034-1041Zhou Z H,Zhao J L,Wei X D,et al. Co-occurrence and ecological risk of antibiotics in surface water of Guangzhou section of Pearl River[J]. Ecology and Environmental Sciences,2017,26(6):1034-1041(in Chinese)
[4]柴玉峰，张玉秀，陈梅雪，等．冀西北典型北方小城镇污水处理厂中抗生素的分布和去除[J]．环境科学，2018,39(6):2724-2731Chai Y F,Zhang Y X,Chen M X,et al. Distribution and treatment of antibiotics in typical WWTPs in small towns in China[J]. Environmental Science,2018,39(6):2724-2731(in Chinese)
[5]郝勤伟，徐向荣，陈辉，等．广州市南沙水产养殖区抗生素的残留特性[J]．热带海洋学报，2017,36(1):106-113Hao Q W,Xu X R,Chen H,et al. Residual antibiotics in the Nansha aquaculture area of Guangzhou[J]. Journal of Tropical Oceanography,2017,36(1):106-113(in Chinese)
[6]杨基峰，应光国，赵建亮，等．配套养殖体系中部分抗生素的污染特征[J]．环境化学，2015,34(1):54-59Yang J F,Ying G G,Zhao J L,et al. Pollution characteristics of antibiotics in complete sets of farming system[J]. Environmental Chemistry,2015,34(1):54-59(in Chinese)
[7]陈卫平，彭程伟，杨阳，等．北京市地下水中典型抗生素分布特征与潜在风险[J]．环境科学，2017,38(12):5074-5080Chen W P,Peng C W,Yang Y,et al. Distribution characteristics and risk analysis of antibiotic in the groundwater in Beijing[J]. Environmental Science,2017,38(12):5074-5080(in Chinese)
[8]张新波，宋姿，张丹，等．天津供水系统中抗生素分布变化特征与健康风险评价[J]．环境科学，2018,39(1):99-108Zhang X B,Song Z,Zhang D,et al. Distribution characteristics and health risk assessment of antibiotics in the water supply system in Tianjin[J]. Environmental Science,2018,39(1):99-108(in Chinese)
[9] Yiruhan,Wang Q J,Mo C H,et al. Determination of four fluoroquinolone antibiotics in tap water in Guangzhou and Macao[J]. Environmental Pollution,2010,158(7):2350-2358
[10]陈月，王风贺，陆建刚，等．长江流域药品和个人护理用品污染状况的研究进展[J]．工业水处理，2016,36(7):11-15Chen Y,Wang F H,Lu J G,et al. Research progress in pharmaceutical and personal care products(PPCPs)in the Yangtze River Valley,China[J]. Industrial Water Treatment,2016,36(7):11-15(in Chinese)
[11]唐娜，张圣虎，陈玫宏，等．长江南京段表层水体中12种磺胺类抗生素的污染水平及风险评价[J]．环境化学，2018,37(3):505-512Tang N,Zhang S H,Chen M H,et al. Contamination level and risk assessment of 12 sulfonamides in surface water of Nanjing reach of the Yangtze River[J]. Environmental Chemistry,2018,37(3):505-512(in Chinese)
[12]孙雨，丁剑楠，卢婕，等．长江南京段水源地抗生素污染特征及主要来源分析[J]．环境监测管理与技术，2017,29(2):26-30Sun Y,Ding J N,Lu J,et al. Occurrence and ecological risk assessment of emerging pollutants in surface water at Nanjing Section in the Yangtze River[J]. The Administration and Technique of Environmental Monitoring,2017,29(2):26-30(in Chinese)
[13]封丽，程艳茹，封雷，等．三峡库区主要水域典型抗生素分布及生态风险评估[J]．环境科学研究，2017,30(7):1031-1040Feng L,Cheng Y R,Feng L,et al. Distribution of typical antibiotics and ecological risk assessment in main waters of Three Gorges Reservoir area[J]. Research of Environmental Sciences,2017,30(7):1031-1040(in Chinese)
[14]郭惠卫，于南洋，王学兵，等．环境有毒有害物质快速鉴别方法与应用[J]．生态毒理学报，2017,12(3):336-345Guo H W,Yu N Y,Wang X B,et al. A rapid highthroughput method for screening environmental toxic and hazardous substances in solid waste[J]. Asian Journal of Ecotoxicology,2017,12(3):336-345(in Chinese)
[15]李红英，沈华旦，方江济，等．超高效液相色谱-线性离子阱/静电场轨道阱质谱法快速检测化妆品中66种抗生素[J]．色谱，2018,36(7):643-650Li H Y,Shen H D,Fang J J,et al. Rapid determination of 66 antibiotics in cosmetics using ultra high performance liquid chromatography-linear ion trap/Orbitrap mass spectrometry[J]. Chinese Journal of Chromatography,2018,36(7):643-650(in Chinese)
[16]王培锋，王凤美，张鸿伟，等．高效液相色谱-四极杆轨道阱高分辨质谱对动物源食品中抗生素类成分的快速筛查[J]．食品安全质量检测学报，2014,5(12):3769-3777Wang P F,Wang F M,Zhang H W,et al. Screening of antibiotics in foodstuffs of animal origin by high performance liquid chromatography-quadrurpole/electrostatic field orbitrap high resolution mass spectrometry[J].Journal of Food Safety and Quality,2014,5(12):3769-3777(in Chinese)
[17]卜庆伟，王东红，王子健．基于风险分析的流域优先有机污染物筛查:方法构建[J]．生态毒理学报，2016,11(1):61-69Bu Q W,Wang D H,Wang Z J. A risk-based screening approach for priority organic contaminants at the watershed scale:Method development[J]. Asia Journal of Ecotoxicology,2016,11(1):61-69(in Chinese)
[18]方龙飞，魏群山，王元宏，等．上海黄浦江上游典型抗生素来源及分布污染特征研究[J]．环境污染与防治，2017,39(3):301-306Fang L F,Wei Q S,Wang Y H,et al. Source and distribution of typical antibiotics in the upper Huangpu River,Shanghai[J]. Environmental Pollution&Control,2017,39(3):301-306(in Chinese)
[19]黄俊，衣俊，程金平．长江口及近海水环境中新型污染物研究进展[J]．环境化学，2014,33(9):1484-1494Huang J,Yi J,Cheng J P. Emerging contaminants in the Yangtze estuary and adjacent coastal area,China[J].Environmental Chemistry,2014,33(9):1484-1494(in Chinese)
[20]刘晓晖．洞庭湖流域水环境中典型抗生素污染特征、来源及风险评估[D]．济南:山东师范大学，2017:70-71Liu X H. Pollution level,source and ecological risk of typical antibiotics in the Dongting Lake,China[J]. Jinan:Shandong Normal University,2017:70-71(in Chinese)
[21] Gu H F,Shi C. The effect of quinolones in the treatment of pulmonary tuberculosis[J]. China Continuing Medical Education,2018(21):128-130
[22] Guidi L R,Santos F A,Ribeiro A,et al. Quinolones and tetracyclines in aquaculture fish by a simple and rapid LCMS/MS method[J]. Food Chemistry,2018,245:1232
[23]高品，王宇晖，刘振鸿，等．水中抗生素药物的迁移分布特征研究进展[J]．环境科学与技术，2013,36(7):58-63Gao P,Wang Y H,Liu Z H,et al. Transport and distribution of antibiotics in environmental waters:A review[J]. Environmental Science&Technology,2013,36(7):58-63(in Chinese)
[24]易成．医院废水中抗生素残留及某市重金属污染研究[D]．哈尔滨:哈尔滨医科大学，2013:24Yi C. Study on detection of 9 antibiotics residues in hospital wastewater by SPE/HPLC[D]. Harbin:Harbin Medical University,2013:24(in Chinese)
[25]魏晓东．广州典型排放源废水和河流水体中抗生素的污染特征研究[D]．北京:中国科学院大学，2018:6-7Wei X D. Contamination of antiobiotics in typical emission sources and a river in Guangzhou[D]. Beijing:Univerisy of Chinese Academy,2018:6-7(in Chinese)
[26]凌文翠，范玉梅，方瑶瑶，等．京津冀地区畜禽养殖业抗生素污染现状分析[J]．环境工程技术学报，2018,8(4):390-397Ling W C,Fan Y M,Fang Y Y,et al. Antibiotics pollution of livestock and poultry breeding in Beijing-TianjinHebei region[J]. Journal of Environmental Engineering Technology,2018,8(4):390-397(in Chinese)
[27]蔡俊波，王爱玲，李海敏，等．陕南白山羊伪结核棒状杆菌分离鉴定及灭活铝胶疫苗研制[J]．动物医学进展，2016,37(7):49-52Cai J B,Wang A L,Li H M,et al. Isolation and identification of Corynebacterium psedotuberculosis from white goat in South Shaanxi and development of an inativated vaccine with aluminum hydroxide adjuvant[J]. Progress in Veterinary Medicine,2016,37(7):49-52(in Chinese)
[28]李宁．猪支原体肺炎的特征与防治[J]．养殖与饲料，2018(4):48
[29]陈国金．水产养殖水中抗生素的残留特性及其去除技术研究[D]．广州:广东工业大学，2015:20Chen G J. Study on residual charaterization of antibiotics in aquaculture wastewater and its removal technology[D]. Guangzhou:Guangdong University of Technology,2015:20(in Chinese)
[30]张丹丹，郭亚平，任红云，等．福建省敖江下游抗生素抗性基因分布特征[J]．环境科学，2018,39(6):2600-2606Zhang D D,Guo Y P,Ren H Y,et al. Characteristics of antibiotic resistance genes in downstream areas of the Aojiang River,Fujian Province[J]. Environmental Science,2018,39(6):2600-2606(in Chinese)
[31]庄榆佳，侯梅芳，耿春女．畜禽养殖废水中抗生素和抗性基因的去除技术进展[J]．上海应用技术学院学报:自然科学版，2016,16(2):117-123Zhuang Y J,Hou M F,Geng C N. A review on treatment technologies of antibiotics and its resistance genes in livestock wastewater[J]. Journal of Shanghai Institute of Technology:Natural Science,2016,16(2):117-123(in Chinese)
[32] Lien L T Q,Hoa N Q,Chuc N T K,et al. Antibiotics in wastewater of a rural and an urban hospital before and after wastewater treatment,and the relationship with antibiotic use—A one year study from Vietnam[J]. International Journal of Environmental Research&Public Health,2016,13(6):588
[33]姜凌霄．鄱阳湖区典型养猪场废水抗生素污染特征及催化降解研究[D]．南昌:南昌航空大学，2012:37Jiang L X. Pollution charateristics of typical antibiotics in livestock wastewater from Poyang-Lake district and its photocatalytic degradation[D]. Nanchang:Nanchang Hangkong University,2012:37(in Chinese)
[2]蒋晓霞．抗生素类药物在某典型性流域水环境中的分布特征[D]．深圳:深圳大学，2015:1-2Jiang X X. Distribution of typical antibotics in the aquatic environment of the River[D]. Shenzhen:Shenzhen University,2015:1-2(in Chinese)
[3]周志洪，赵建亮，魏晓东，等．珠江广州段水体抗生素的复合污染特征及其生态风险[J]．生态环境学报，2017,26(6):1034-1041Zhou Z H,Zhao J L,Wei X D,et al. Co-occurrence and ecological risk of antibiotics in surface water of Guangzhou section of Pearl River[J]. Ecology and Environmental Sciences,2017,26(6):1034-1041(in Chinese)
[4]柴玉峰，张玉秀，陈梅雪，等．冀西北典型北方小城镇污水处理厂中抗生素的分布和去除[J]．环境科学，2018,39(6):2724-2731Chai Y F,Zhang Y X,Chen M X,et al. Distribution and treatment of antibiotics in typical WWTPs in small towns in China[J]. Environmental Science,2018,39(6):2724-2731(in Chinese)
[5]郝勤伟，徐向荣，陈辉，等．广州市南沙水产养殖区抗生素的残留特性[J]．热带海洋学报，2017,36(1):106-113Hao Q W,Xu X R,Chen H,et al. Residual antibiotics in the Nansha aquaculture area of Guangzhou[J]. Journal of Tropical Oceanography,2017,36(1):106-113(in Chinese)
[6]杨基峰，应光国，赵建亮，等．配套养殖体系中部分抗生素的污染特征[J]．环境化学，2015,34(1):54-59Yang J F,Ying G G,Zhao J L,et al. Pollution characteristics of antibiotics in complete sets of farming system[J]. Environmental Chemistry,2015,34(1):54-59(in Chinese)
[7]陈卫平，彭程伟，杨阳，等．北京市地下水中典型抗生素分布特征与潜在风险[J]．环境科学，2017,38(12):5074-5080Chen W P,Peng C W,Yang Y,et al. Distribution characteristics and risk analysis of antibiotic in the groundwater in Beijing[J]. Environmental Science,2017,38(12):5074-5080(in Chinese)
[8]张新波，宋姿，张丹，等．天津供水系统中抗生素分布变化特征与健康风险评价[J]．环境科学，2018,39(1):99-108Zhang X B,Song Z,Zhang D,et al. Distribution characteristics and health risk assessment of antibiotics in the water supply system in Tianjin[J]. Environmental Science,2018,39(1):99-108(in Chinese)
[9] Yiruhan,Wang Q J,Mo C H,et al. Determination of four fluoroquinolone antibiotics in tap water in Guangzhou and Macao[J]. Environmental Pollution,2010,158(7):2350-2358
[10]陈月，王风贺，陆建刚，等．长江流域药品和个人护理用品污染状况的研究进展[J]．工业水处理，2016,36(7):11-15Chen Y,Wang F H,Lu J G,et al. Research progress in pharmaceutical and personal care products(PPCPs)in the Yangtze River Valley,China[J]. Industrial Water Treatment,2016,36(7):11-15(in Chinese)
[11]唐娜，张圣虎，陈玫宏，等．长江南京段表层水体中12种磺胺类抗生素的污染水平及风险评价[J]．环境化学，2018,37(3):505-512Tang N,Zhang S H,Chen M H,et al. Contamination level and risk assessment of 12 sulfonamides in surface water of Nanjing reach of the Yangtze River[J]. Environmental Chemistry,2018,37(3):505-512(in Chinese)
[12]孙雨，丁剑楠，卢婕，等．长江南京段水源地抗生素污染特征及主要来源分析[J]．环境监测管理与技术，2017,29(2):26-30Sun Y,Ding J N,Lu J,et al. Occurrence and ecological risk assessment of emerging pollutants in surface water at Nanjing Section in the Yangtze River[J]. The Administration and Technique of Environmental Monitoring,2017,29(2):26-30(in Chinese)
[13]封丽，程艳茹，封雷，等．三峡库区主要水域典型抗生素分布及生态风险评估[J]．环境科学研究，2017,30(7):1031-1040Feng L,Cheng Y R,Feng L,et al. Distribution of typical antibiotics and ecological risk assessment in main waters of Three Gorges Reservoir area[J]. Research of Environmental Sciences,2017,30(7):1031-1040(in Chinese)
[14]郭惠卫，于南洋，王学兵，等．环境有毒有害物质快速鉴别方法与应用[J]．生态毒理学报，2017,12(3):336-345Guo H W,Yu N Y,Wang X B,et al. A rapid highthroughput method for screening environmental toxic and hazardous substances in solid waste[J]. Asian Journal of Ecotoxicology,2017,12(3):336-345(in Chinese)
[15]李红英，沈华旦，方江济，等．超高效液相色谱-线性离子阱/静电场轨道阱质谱法快速检测化妆品中66种抗生素[J]．色谱，2018,36(7):643-650Li H Y,Shen H D,Fang J J,et al. Rapid determination of 66 antibiotics in cosmetics using ultra high performance liquid chromatography-linear ion trap/Orbitrap mass spectrometry[J]. Chinese Journal of Chromatography,2018,36(7):643-650(in Chinese)
[16]王培锋，王凤美，张鸿伟，等．高效液相色谱-四极杆轨道阱高分辨质谱对动物源食品中抗生素类成分的快速筛查[J]．食品安全质量检测学报，2014,5(12):3769-3777Wang P F,Wang F M,Zhang H W,et al. Screening of antibiotics in foodstuffs of animal origin by high performance liquid chromatography-quadrurpole/electrostatic field orbitrap high resolution mass spectrometry[J].Journal of Food Safety and Quality,2014,5(12):3769-3777(in Chinese)
[17]卜庆伟，王东红，王子健．基于风险分析的流域优先有机污染物筛查:方法构建[J]．生态毒理学报，2016,11(1):61-69Bu Q W,Wang D H,Wang Z J. A risk-based screening approach for priority organic contaminants at the watershed scale:Method development[J]. Asia Journal of Ecotoxicology,2016,11(1):61-69(in Chinese)
[18]方龙飞，魏群山，王元宏，等．上海黄浦江上游典型抗生素来源及分布污染特征研究[J]．环境污染与防治，2017,39(3):301-306Fang L F,Wei Q S,Wang Y H,et al. Source and distribution of typical antibiotics in the upper Huangpu River,Shanghai[J]. Environmental Pollution&Control,2017,39(3):301-306(in Chinese)
[19]黄俊，衣俊，程金平．长江口及近海水环境中新型污染物研究进展[J]．环境化学，2014,33(9):1484-1494Huang J,Yi J,Cheng J P. Emerging contaminants in the Yangtze estuary and adjacent coastal area,China[J].Environmental Chemistry,2014,33(9):1484-1494(in Chinese)
[20]刘晓晖．洞庭湖流域水环境中典型抗生素污染特征、来源及风险评估[D]．济南:山东师范大学，2017:70-71Liu X H. Pollution level,source and ecological risk of typical antibiotics in the Dongting Lake,China[J]. Jinan:Shandong Normal University,2017:70-71(in Chinese)
[21] Gu H F,Shi C. The effect of quinolones in the treatment of pulmonary tuberculosis[J]. China Continuing Medical Education,2018(21):128-130
[22] Guidi L R,Santos F A,Ribeiro A,et al. Quinolones and tetracyclines in aquaculture fish by a simple and rapid LCMS/MS method[J]. Food Chemistry,2018,245:1232
[23]高品，王宇晖，刘振鸿，等．水中抗生素药物的迁移分布特征研究进展[J]．环境科学与技术，2013,36(7):58-63Gao P,Wang Y H,Liu Z H,et al. Transport and distribution of antibiotics in environmental waters:A review[J]. Environmental Science&Technology,2013,36(7):58-63(in Chinese)
[24]易成．医院废水中抗生素残留及某市重金属污染研究[D]．哈尔滨:哈尔滨医科大学，2013:24Yi C. Study on detection of 9 antibiotics residues in hospital wastewater by SPE/HPLC[D]. Harbin:Harbin Medical University,2013:24(in Chinese)
[25]魏晓东．广州典型排放源废水和河流水体中抗生素的污染特征研究[D]．北京:中国科学院大学，2018:6-7Wei X D. Contamination of antiobiotics in typical emission sources and a river in Guangzhou[D]. Beijing:Univerisy of Chinese Academy,2018:6-7(in Chinese)
[26]凌文翠，范玉梅，方瑶瑶，等．京津冀地区畜禽养殖业抗生素污染现状分析[J]．环境工程技术学报，2018,8(4):390-397Ling W C,Fan Y M,Fang Y Y,et al. Antibiotics pollution of livestock and poultry breeding in Beijing-TianjinHebei region[J]. Journal of Environmental Engineering Technology,2018,8(4):390-397(in Chinese)
[27]蔡俊波，王爱玲，李海敏，等．陕南白山羊伪结核棒状杆菌分离鉴定及灭活铝胶疫苗研制[J]．动物医学进展，2016,37(7):49-52Cai J B,Wang A L,Li H M,et al. Isolation and identification of Corynebacterium psedotuberculosis from white goat in South Shaanxi and development of an inativated vaccine with aluminum hydroxide adjuvant[J]. Progress in Veterinary Medicine,2016,37(7):49-52(in Chinese)
[28]李宁．猪支原体肺炎的特征与防治[J]．养殖与饲料，2018(4):48
[29]陈国金．水产养殖水中抗生素的残留特性及其去除技术研究[D]．广州:广东工业大学，2015:20Chen G J. Study on residual charaterization of antibiotics in aquaculture wastewater and its removal technology[D]. Guangzhou:Guangdong University of Technology,2015:20(in Chinese)
[30]张丹丹，郭亚平，任红云，等．福建省敖江下游抗生素抗性基因分布特征[J]．环境科学，2018,39(6):2600-2606Zhang D D,Guo Y P,Ren H Y,et al. Characteristics of antibiotic resistance genes in downstream areas of the Aojiang River,Fujian Province[J]. Environmental Science,2018,39(6):2600-2606(in Chinese)
[31]庄榆佳，侯梅芳，耿春女．畜禽养殖废水中抗生素和抗性基因的去除技术进展[J]．上海应用技术学院学报:自然科学版，2016,16(2):117-123Zhuang Y J,Hou M F,Geng C N. A review on treatment technologies of antibiotics and its resistance genes in livestock wastewater[J]. Journal of Shanghai Institute of Technology:Natural Science,2016,16(2):117-123(in Chinese)
[32] Lien L T Q,Hoa N Q,Chuc N T K,et al. Antibiotics in wastewater of a rural and an urban hospital before and after wastewater treatment,and the relationship with antibiotic use—A one year study from Vietnam[J]. International Journal of Environmental Research&Public Health,2016,13(6):588
[33]姜凌霄．鄱阳湖区典型养猪场废水抗生素污染特征及催化降解研究[D]．南昌:南昌航空大学，2012:37Jiang L X. Pollution charateristics of typical antibiotics in livestock wastewater from Poyang-Lake district and its photocatalytic degradation[D]. Nanchang:Nanchang Hangkong University,2012:37(in Chinese)
© 2004-2018 中国地质图书馆版权所有 京ICP备05064691号 京公网安备11010802017129号 地址：北京市海淀区学院路29号 邮编：100083 电话：办公室：(+86 10)66554848；文献借阅、咨询服务、科技查新：66554700 |