凉血消风散治疗寻常型银屑病进行期的临床观察
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摘要
研究目的:
(1)评价凉血消风散治疗寻常型银屑病进行期血热证的临床疗效及其安全性;
(2)观察该方对银屑病远期疗效及复发情况的影响;
(3)银屑病患者生活质量评估。
研究方法:
(1)采用随机、对照的方法,客观评价凉血消风散的总体疗效及其安全性;
(2)治疗痊愈患者做远期疗效随访,观察复发情况;
(3)采用DLQI研究银屑病患者治疗前、后生活质量,并与传统的银屑病皮损面积和严重度指数(PASI)进行比较。
结果:
(1)通过对比治疗前后PASI评分情况,经SPSS13.0统计分析结果,表明凉血消风散治疗寻常型银屑病进行期血热证疗效显著,与阿维A胶囊组疗效相当,优于复方青黛胶囊(P＜0.05)。
(2)对痊愈患者做远期疗效随访,治疗组复发率明显低于对照1、2组(P＜0.05),不良事件发生率明显低于对照1、2组。
(3)治疗后随着临床病情的改善,PASI和DLQI评分均显著下降,且DLQI改善率和PASI改善率呈显著正相关(P＜0.01)。
结论:
(1)凉血消风散能够显著改善银屑病血热证患者的皮损表现和瘙痒程度,降低皮损的PASI评分,疗效优于复方青黛胶囊,与阿维A胶囊相当,但毒副作用极少;降低复发率均优于复方青黛胶囊与阿维A胶囊组;
(2)银屑病对患者生活质量的影响较大,DLQI可作为判断银屑病病情及疗效的指标。
Objective:
(1) Evaluate the validity and security of Liang Xue Xiao Feng San decoction in treating active psorasis vulgaris,which belongs to blood-heat pattern in Traditional Chinese Medicine(TCM);
(2) To observe the prostecdtive efficacy;
(3) To study the effect of psoriasis on the patients' life quality
Methods:
(1) In the clinical observation,according to the rule of single blind,random and
contrast,88 patients were divided into 3 groups:theraputic (n=29)group and control(n=30) group1, control(n=29) group2. theraputic group taking proved recipe Liangxue xiao feng san; control group1 taking Fu Fang Qing Dai capsule; control group2 taking Acitretine.To evaluate the validity , prostecdtive efficacy, recurrence rate and security;
(2) To observe recurrence,following up the recovery patients for one year;
(3) Using DLQI to study the life quality in the patients with psoriasis before and after treatment and comparing it with psoriasis area and severity index (PASI).
Results:
(1) Evaluate the treatment effect by PASI scores 8 weeks later, and analyze it with the software of SPSS13.0.As a result, Liang Xue Xiao Feng San decoction is more effective than Fu Fang Qing Dai capsule; Nearly the same as Acitretine. (P<0.05).
(2) Following up the recovery patient for one year, recurrence rate of theraputic group is lower than control groupl and 2 (P<0.05).
(3)Both PASI and DLQI decreased with clinical improvement after treatment. There was also a significantly positive correlation of the response rate between in PASI and DLQI scores ( P < 0.01).
Conclusion:
(1) The Liang Xue Xiao Feng San can significantly improve the skin lesions, pruritus degrees.reduce the PASI scores and decrease recurrence rate in blood heat syndrome of psoriasis vulgaris. Its therapeutic effects are better than the Fu Fang Qing Dai capsule; Its therapeutic effects nearly the same as theraputic group,but the side effects are more severe.
(2) Psoriasis has marked effect on patients life quality and DLQI score can be a new severity and therapeutic index of psoriasis.
(1)评价凉血消风散治疗寻常型银屑病进行期血热证的临床疗效及其安全性;
(2)观察该方对银屑病远期疗效及复发情况的影响;
(3)银屑病患者生活质量评估。
研究方法:
(1)采用随机、对照的方法,客观评价凉血消风散的总体疗效及其安全性;
(2)治疗痊愈患者做远期疗效随访,观察复发情况;
(3)采用DLQI研究银屑病患者治疗前、后生活质量,并与传统的银屑病皮损面积和严重度指数(PASI)进行比较。
结果:
(1)通过对比治疗前后PASI评分情况,经SPSS13.0统计分析结果,表明凉血消风散治疗寻常型银屑病进行期血热证疗效显著,与阿维A胶囊组疗效相当,优于复方青黛胶囊(P＜0.05)。
(2)对痊愈患者做远期疗效随访,治疗组复发率明显低于对照1、2组(P＜0.05),不良事件发生率明显低于对照1、2组。
(3)治疗后随着临床病情的改善,PASI和DLQI评分均显著下降,且DLQI改善率和PASI改善率呈显著正相关(P＜0.01)。
结论:
(1)凉血消风散能够显著改善银屑病血热证患者的皮损表现和瘙痒程度,降低皮损的PASI评分,疗效优于复方青黛胶囊,与阿维A胶囊相当,但毒副作用极少;降低复发率均优于复方青黛胶囊与阿维A胶囊组;
(2)银屑病对患者生活质量的影响较大,DLQI可作为判断银屑病病情及疗效的指标。
Objective:
(1) Evaluate the validity and security of Liang Xue Xiao Feng San decoction in treating active psorasis vulgaris,which belongs to blood-heat pattern in Traditional Chinese Medicine(TCM);
(2) To observe the prostecdtive efficacy;
(3) To study the effect of psoriasis on the patients' life quality
Methods:
(1) In the clinical observation,according to the rule of single blind,random and
contrast,88 patients were divided into 3 groups:theraputic (n=29)group and control(n=30) group1, control(n=29) group2. theraputic group taking proved recipe Liangxue xiao feng san; control group1 taking Fu Fang Qing Dai capsule; control group2 taking Acitretine.To evaluate the validity , prostecdtive efficacy, recurrence rate and security;
(2) To observe recurrence,following up the recovery patients for one year;
(3) Using DLQI to study the life quality in the patients with psoriasis before and after treatment and comparing it with psoriasis area and severity index (PASI).
Results:
(1) Evaluate the treatment effect by PASI scores 8 weeks later, and analyze it with the software of SPSS13.0.As a result, Liang Xue Xiao Feng San decoction is more effective than Fu Fang Qing Dai capsule; Nearly the same as Acitretine. (P<0.05).
(2) Following up the recovery patient for one year, recurrence rate of theraputic group is lower than control groupl and 2 (P<0.05).
(3)Both PASI and DLQI decreased with clinical improvement after treatment. There was also a significantly positive correlation of the response rate between in PASI and DLQI scores ( P < 0.01).
Conclusion:
(1) The Liang Xue Xiao Feng San can significantly improve the skin lesions, pruritus degrees.reduce the PASI scores and decrease recurrence rate in blood heat syndrome of psoriasis vulgaris. Its therapeutic effects are better than the Fu Fang Qing Dai capsule; Its therapeutic effects nearly the same as theraputic group,but the side effects are more severe.
(2) Psoriasis has marked effect on patients life quality and DLQI score can be a new severity and therapeutic index of psoriasis.
引文
[1]赵辨,张振楷,倪容之等.临床皮肤病学,南京:江苏科学技术出版社,2001,第3版:759-760
[2]Schmitt J,Wozel G.The psoriasis area and severity index is the adequate criterion to define severity in chronic plaque- type psoriasis[J].Dermatology,2005,210(3):194-199
[3]郑筱萸.中药新药临床研究指导原则(试行)[M].北京:中国医药科技出版社,2002.299-302.
[4]vande Kerkhof PC.The Psoriasis Area and Severity Index and alternativeapproaches for the assessment of severity:persisting areas of confusion[J].Br J Dermatol,1997,137(4):661-662
[5]Finlay AY,Khan GK.Dermatology Life Qualith Index(DLQI) - a simple practical measure for routine clinical use[J].Clinical and Experimental Dermatology,1994,19(3):210-216.
[6]Kirby B,Fortune DGS Bhushan M,Chalmers RJ,Griffiths CE.The Salford Psoriasis Index:an holistic measure of psoriasis severity[J].Br J Dermatol 2000;142(4):728-732
[7]Harari M,Shani J,Hristakieva E,Stanimirovic A,Seidl W,Burdo A.Clinicalevaluation of a more rapid and sensitive Psoriasis Assessment Severity Score(PASS),and its comparison with the classic method of Psoriasis Area and Severity Index(PASI),before and after climatotherapy at the Dead-Sea[J].Int J Dermatol 2000:39(12):913-918
[8]Callen JP,Krueger GG,Lebwohl M,McBurney El,Mease P,Menter A,Palter AS,Pariser DM,Weinblatt M,Zimmerman G AAD consensus statement on psoriasis therapies[J].JAm Acad Dermatol 2003,49(5):897-899
[9]Krueger G,KooJ,Lebwohl M,etal.The impact of psoriasis on quality of life:results of a 1998 National Psoriasis Foundation patient-membership survey[J].Arch Dermatol,2001,137(3):280-284.
[10]北京中医学院.赵炳南临床经验集.北京:人民卫生出版社,1975:226Suttera SP,Qian ZF,Boylan CW.Effects ofthere Chinese medical herbs on RBC deform ability[J].Clin He Morrheol,2001,71(6):773.
[11]李林,李博鉴.朱仁康老中医治疗银屑病的经验.中医杂志.1985,26(1):23-24
[12]顾伯华.中医外科临床手册[M]上海:上海科学技术出版社。1986:364
[13]刘凤年.卢传坚教授治疗银屑病经验介绍.新中医2006.6.第38卷第6期:13
[14]王丽,焦国梅,赵跃芹等.银屑病患者活血化疲药物治疗前后血液流变学观察.临床皮肤科杂志,1998,02,15.27(1):33-34
[15]吴绍熙.银屑病患者“血瘀”实质的研究.全国首届银屑病学术会议论文汇编,1997.238
[16]Orru S,GiuressiE,Casula M,et al.Psoriasis is associated with a SNP haplotype of the comeodesmosin gene.(CDSN).Tissue A nti-Gens,2003,33:1-6
[17]O'Brien KP,Holm SJ,Nilsson S,etal.The HCR gene on 6p21 is unlikely to.be a psoriasis susceptibility gene.J Invest Dermatol,2001,116(5):750-754
[18]王侠生,寥康煌主编.杨国亮皮肤病学,上海:上海科学技术文献出版社,2005,第1版:505-510
[19]Krueger JCxThe immunologic basis for the treatment of psoriasis with new biologic agents.J Am Dermatol.2002.46(1):1-23
[20]杨洪浦,冯志合156例银屑病患者外周血T淋巴细胞亚群的表现,皮肤病与性病,2002,24(3):1-2
[21]朱可建,尚惠英,劳力民等,寻常型银屑病患者外周血T淋巴细胞CD25和CD69的表达,中华皮肤科杂志,2003,36(3):142-144
[22]阎衡,叶庆佾,郝飞等,银屑病Th1/Th2模式的体外试验,第三军医大学学报,2001,23,(1):1335-1336
[23]刘元林,王刚,张晓东等,银屑病患者外周血单个核细胞Th1/Th2细胞因子表达研究,中国皮肤性病学杂志,2003,17(3):167-168
[24]徐娟,贾随旺,钟绮丽,等.银屑病皮损细胞凋亡的研究.岭南皮肤性病科杂志,2004 11(2):91-93。
[25]SkovL,Baadsgaard O.Bacterial superantigens and inflammatory skin diseases.Clin Exp Dermatol,2000,25(1):57-61.
[26]王丽,焦国梅,赵跃芹等.银屑病患者活血化疲药物治疗前后血液流变学观察.临床皮肤科杂志,1998,02,15:27(1):33-34
[27]秦万章.现代中医药应用与研究大系一皮肤科.上海:上海中医药大学出版社,1994,225
[28]何众玲.银屑病发病机制的神经免疫研究进展北京医科大学学报,2000,32(4):362-365
[29]杨雪琴,张力军,李铀等.生物反馈治疗银屑病的应用研究北京生物医学工程,2003,22(4):290
[30]杨维玲,孙丽梅,张峰等.寻常型银屑病诱发因素分析,中华临床医药杂志,2003.4(1):16-19。
[31]葛宏松,杨森,李明等.银屑病患者居住环境及饮用水类型与其发病的流行病学研究,安徽医科大学学报2002,37(6):447-450
[32]Suttera SP,Qian ZF,Boylan CW.Effects of there Chinese medical herbs on RBC deform ability[J].Clin He Morrheol,2001,71(6):773.
[33]崔健,施松善,王顺春等.白花蛇舌草的化学成分及药理作用研究进展[J].上海中医药杂志,2005,39(7):57-59.
[34]高章图,张建新,徐铎等.甘草酸抗炎抗病毒及免疫调节作用研究进展.解放军药学学报,1999:15(5):27.
[35]李光华,周旭,贺弋等.龙骨免疫作用的实验研究.江苏中医药,2003,24(4):54-55
[36]王法权.郑卫东.马春玲等.合欢皮对小鼠免疫功能的调节作用.临沂医专学报,2000,22(3):201.
[37]李茹,丁安伟,孟丽.女贞子多糖的免疫调节作用研究.中药药理与临床.2001,17(2):11-12。
[38]王德仁.齐墩果酸研究新进展.天津药学,2003,15(3):56-58
[39]李明.甘草的研究概况.甘肃中医学院学报,2000:17(3):59-63
[40]杨骥,张毅,杨雪.白鲜皮对急性微循环障碍大鼠血管内皮分泌的细胞因子 和黏附分子表达的影响.中国中西医结合皮肤性病学杂志2006年第5卷第2期,80-82
[41]黄海英,彭新君,彭延吉.僵蚕的现代研究进展[J].湖南中医学院学报,2003,23(4):62
[42]赵润生,张一昕,苗冬雪等.生地黄对血瘀模型大鼠血液流变性的影响.中药药理与临床,2006,22(3、4):12
[43]毛宏德.白僵蛹中白僵菌素的分离和鉴定[J].中草药,1985,7;5-6.
[44]李仲兴,王秀华,岳云升等紫荆皮对336株临床菌株的体外抗菌活性的研究,中国中医药科技[J],2000.7卷6期,391-392
[45]杜程芳,杨欣欣,屠鹏飞.白鲜皮的化学成分研究[J].中国中药杂志,2005,30(21):1663-1666.
[46]王嵩.中草药抗细菌感染的研究[J].北京中医杂志,2002,21(4):249-251.
[47]路又璐,秦建中.17味中药对培养的表皮细胞增殖的影响[J].临床皮肤科杂志,1996,25(4):202.
[48]乐杰主编.妇产科学.第四版.北京:人民卫生出版社,1980;19
[49]卫功庆,鞠贵春,李慧萍.白僵蚕化学成分的分析[J].吉林农业大学学报,1995,17(3):46
[50]李国均.中国药材学[M].北京:中国医药科技出版社,1996.1997.
[51]蓝昆山,王秀琴等.现代临床中药学[MI.北京:中国中医药出版社.1998:78-554
[52]雷载权,张廷模.中华临床中药学[M].北京:人民卫生出版社,1998.315,1474
[53]董映枢.合欢皮治疗失眠小议[J].浙江中医杂志,1988,23(9):424
[1]Wiegand UW,Chou RC.Pharmacokinetics of acitretin and etretinate[J].J Am Acad Dermatol,1998,39(2 Pt 3):S25 - 33
[2]马成林.银屑病治疗进展.中国全科医学,2001,4(11):847
[3]Kumar B,Saraswat A,Kaur I.Rediscover2ing hydroxyurea:its role in recalcitrant psoriasis[J].Invt J Dermatol,2001,40(8):530 - 534.
[4]Robertshaw H.Friedmann PS.Pioglitazone:a promising therapy for psoriasis.Br JDermatolo 2o05.152:189-91.
[5]Bongartz T,Coras B,Vogt T,et al.Treatment of active psoriatic arthritiswith the PPAR gammaligan d pioglitazone:an open-label pilot study.Rheumatology(Oxford),2005,44:126-129
[6]Lebwohl M.A clinician' s paradigm in the treatment of psoriasis.J Am Acad Dermatol.2005.53(1Suppll):S59-69.
[7]Smith CH.Anstey AV,Barker JN,et al.British Association of Dermatologists guidelines for lIse of biological interventions in psoriasis 2005.Br J Darmatol.2005.153:486497.
[8]KooJ.Khera P.Update on the mechanisms and efficacy ofbiological therapies for psoriasis.J Dermatol Sci.2005.38:75-87.
[9]Mease PJ.Psoriatic arthritis therapy advances.Chit Opin Rheumatol.2005.17:426-432.
[10]Gottlieb AB.Therapeutic options in the treatment of psoriasis and atopic dermatitis,JAm Acad Dermatol,2005.53(1Suppl 1):S3-16.
[11]Stein L.Clinical studies of a new vehicle formulation for topical corticosteroids in the treatment of psoriasis.J Am Acad Dermatol,2005.53(1Suppl1):S39-49.
[12]Remitz A,Reitamo S,Erkko P,et al.Tacrolimus ointment improves psoriasis in amicroplaque assay[J].Br J Dermatol,1999,141(1):103-107.
[13]Gottlieb AB.Therapeutic options in the treatment of psoriasis and atopic dermatitis,JAm Acad Dermatol,2005.53(1 Suppl 1):S3-16.
[14]Gwendoline K.Atopic dermatitis is associated with a decrement in healthrelated quality of life.Inter J Dermatal 2002;41(2):151-158.
[15]王雅娟,董西林,陈琪等.活血通络汤治疗寻常型银屑病80例陕西中医,2002:23(9):796
[16]陈苏.消银方治疗银屑病,山东中医杂志,1998.17(11):500
[17]李寿甫,杨占魁,韩世荣.脏腑辨证分型治疗银屑病1000例,陕西中医,1998:19(2):60
[18]华刚.辨证论治银屑病78例,,四川中医,2003年第21卷第5期:61-62
[19]李茂兴等.从“血”论治银屑病376例疗效观察.四川中医,1993,6:43-44
[20]高志学.银屑病六型辨治初探.陕西中医,1995,16(5):214-215
[21]张晓红,瞿幸,牛福林等.消银解毒饮对银屑病患者白介素8的影响.中华皮肤科杂志,2000:33(2):124.
[22]娄卫海,张志礼,邓丙戎等凉血活血汤治疗进行期银屑病的临床及实验研究,中华皮肤科杂志1999:32(2):80-81
[23]候素春,刘晓明,宋智琦等.凉血活血复方治疗银屑病.中华皮肤科杂志2003.6第36卷第6期352-353
[24]张武一,王萍.凉血解毒汤治疗进行期寻常型银屑病的疗效观察.现代中西医结合志.2007 Feb.16(6)764-765
[25]孙国强,朱风梅.润燥凉血汤治疗银屑病进行期的临床研究,四川中医,2007年第25卷第2期:92
[26]王萍,张凡,李伟凡等.凉血活血汤治疗寻常型银屑病临床观察及TNF-α水平检测[J].中国皮肤性病学杂志,2001,23(3):20
[27]杨志波,向亚萍,欧阳恒.银屑病患者口服竹黄颗粒剂前后血清白介素6和肿瘤坏死因子水平的比较[J].中华皮肤科杂志,2000,33(6):423
[28]林瑞奋,肖明辉,王斗训.三藤汤治疗寻常型银屑病临床及免疫学研究[J].福建中医学院学报,2000,10(3):8-10
[29]林春爱.雷公藤片治疗寻常型银屑病78例.中国皮肤性病学杂志,1995:9(3):175
[30]周辉,刘桂卿.银屑宁治疗银屑病187例疗效观察.贵阳中医学院杂志,200022(1):31
[31]卢庆芳,孙庆海.复方青黛胶囊与复方青黛丸治疗银屑病比较.中国新药与临床杂志,1999,18(4):250
[32]刘晓明,齐欣,宋智琦等.黄芪注射液治疗银屑病患者的临床观察和实验研究[J].中华皮肤科杂志,2001,34(2):113-114
[33]严志福.话血通络胶囊治疗寻常型银屑病50例疗效观察.临床皮肤科杂志,1996.25(4):245
[34]王宝庭,李学军.生脉注射液治疗银屑病的疗效观察.华西医学杂志,2000,15(1):69
[35]周书岭,朱秀华.耳穴划痕治疗银屑病52例体会.山东医药,2003,43(4):778
[36]梁静涛,宋旭明,廖方正.针刺背俞穴辅以局部灸法治疗银屑病的疗效观察,四川中医.2007年第25卷第5期,105
[37]周志勇,汤成波.针刺治疗银屑病12例.安徽中医临床杂志,2003,15(5):385
[38]褚静.井穴刺血加灸疗治疗银屑病30例.黑龙江中医药,2002,(6):42
[39]田元生.经络全息联合疗法治疗银屑病36例疗效观察.中国针灸,2001,21(7):387
[40]张希平.埋线联合复方青黛丸治疗银屑病88例.医药论坛杂志,2003,24(20):60
[41]缪奇祥.贴棉灸治疗银屑病32例[J].上海针灸杂志,1998,17(1):25.
[42]石桂华,郑建寅,罗铁阳.蜂针配合矿泉浴治疗关节型银屑病[J].中华皮肤科杂志,1997,30(5):346-347
[43]刘群英,钟以泽,陈德华,翁孟武.白疙软膏治疗银屑病的实验研究,广西医科大学学报,2006 Jun;23(3):421
[44]宋坪,颜志芳,许铣,刘瓦利.复方莪倍软膏治疗斑块状银屑病的临床观察,中国中西医结合杂志2007年4月第27卷第4期:352-354
[45]王鹏,高瑾,迪丽努尔等,冰黄肤乐软膏治疗银屑病疗效观察,中国皮肤性 病学杂志2006年12月第20卷第12期
[46]张立新,杨顶权,宋佩华等.普连膏在银屑病治疗中的应用.中医外治杂志,2000,9(5):22-23
[47]陈力,徐丽霞.加味黄芩膏在治疗银屑病中的应用.南京中医药大学学报,2003,19(3):180-181
[48]王东海,陈君霞.平银糊膏敷脐治疗银屑病118例.中医外治杂志,1999,8(3):4
[49]刘卫兵、荆鲁华,谢安莉等.综合疗法治疗银屑病疗效观察.人民军医,2001:44(1):53-54.
[50]王爱民,杨斌刘巧,王玲等.复方甘草酸苷联合窄谱中波紫外线照射治疗寻常性银屑病疗效观察临床皮肤科杂志,2007年36卷第5期,332-333
[51]彭才智,胡贤忠,鲁英等.美能联合窄谱UVB治疗寻常型银屑病疗效观察[J].中国误诊学杂志,2006,6(13):2486-2487.
[52]刘辉,罗平,储利亚.复方甘草酸苷联合卡介菌多糖核酸治疗银屑病疗效观察,中国皮肤性病学杂志,2007年3月第2l卷第3期,192-193
[53]杨素清,闫景东,李志鸿.中药四联综合疗法治疗寻常型银屑病初探,辽宁中医杂志2006年第33卷第7期:843-844
[54]俞利靓,潘祥龙.中西药治疗银屑病96例的疗效和生活质量分析,上海中医药杂志2007年第41卷第1期:43-44
[2]Schmitt J,Wozel G.The psoriasis area and severity index is the adequate criterion to define severity in chronic plaque- type psoriasis[J].Dermatology,2005,210(3):194-199
[3]郑筱萸.中药新药临床研究指导原则(试行)[M].北京:中国医药科技出版社,2002.299-302.
[4]vande Kerkhof PC.The Psoriasis Area and Severity Index and alternativeapproaches for the assessment of severity:persisting areas of confusion[J].Br J Dermatol,1997,137(4):661-662
[5]Finlay AY,Khan GK.Dermatology Life Qualith Index(DLQI) - a simple practical measure for routine clinical use[J].Clinical and Experimental Dermatology,1994,19(3):210-216.
[6]Kirby B,Fortune DGS Bhushan M,Chalmers RJ,Griffiths CE.The Salford Psoriasis Index:an holistic measure of psoriasis severity[J].Br J Dermatol 2000;142(4):728-732
[7]Harari M,Shani J,Hristakieva E,Stanimirovic A,Seidl W,Burdo A.Clinicalevaluation of a more rapid and sensitive Psoriasis Assessment Severity Score(PASS),and its comparison with the classic method of Psoriasis Area and Severity Index(PASI),before and after climatotherapy at the Dead-Sea[J].Int J Dermatol 2000:39(12):913-918
[8]Callen JP,Krueger GG,Lebwohl M,McBurney El,Mease P,Menter A,Palter AS,Pariser DM,Weinblatt M,Zimmerman G AAD consensus statement on psoriasis therapies[J].JAm Acad Dermatol 2003,49(5):897-899
[9]Krueger G,KooJ,Lebwohl M,etal.The impact of psoriasis on quality of life:results of a 1998 National Psoriasis Foundation patient-membership survey[J].Arch Dermatol,2001,137(3):280-284.
[10]北京中医学院.赵炳南临床经验集.北京:人民卫生出版社,1975:226Suttera SP,Qian ZF,Boylan CW.Effects ofthere Chinese medical herbs on RBC deform ability[J].Clin He Morrheol,2001,71(6):773.
[11]李林,李博鉴.朱仁康老中医治疗银屑病的经验.中医杂志.1985,26(1):23-24
[12]顾伯华.中医外科临床手册[M]上海:上海科学技术出版社。1986:364
[13]刘凤年.卢传坚教授治疗银屑病经验介绍.新中医2006.6.第38卷第6期:13
[14]王丽,焦国梅,赵跃芹等.银屑病患者活血化疲药物治疗前后血液流变学观察.临床皮肤科杂志,1998,02,15.27(1):33-34
[15]吴绍熙.银屑病患者“血瘀”实质的研究.全国首届银屑病学术会议论文汇编,1997.238
[16]Orru S,GiuressiE,Casula M,et al.Psoriasis is associated with a SNP haplotype of the comeodesmosin gene.(CDSN).Tissue A nti-Gens,2003,33:1-6
[17]O'Brien KP,Holm SJ,Nilsson S,etal.The HCR gene on 6p21 is unlikely to.be a psoriasis susceptibility gene.J Invest Dermatol,2001,116(5):750-754
[18]王侠生,寥康煌主编.杨国亮皮肤病学,上海:上海科学技术文献出版社,2005,第1版:505-510
[19]Krueger JCxThe immunologic basis for the treatment of psoriasis with new biologic agents.J Am Dermatol.2002.46(1):1-23
[20]杨洪浦,冯志合156例银屑病患者外周血T淋巴细胞亚群的表现,皮肤病与性病,2002,24(3):1-2
[21]朱可建,尚惠英,劳力民等,寻常型银屑病患者外周血T淋巴细胞CD25和CD69的表达,中华皮肤科杂志,2003,36(3):142-144
[22]阎衡,叶庆佾,郝飞等,银屑病Th1/Th2模式的体外试验,第三军医大学学报,2001,23,(1):1335-1336
[23]刘元林,王刚,张晓东等,银屑病患者外周血单个核细胞Th1/Th2细胞因子表达研究,中国皮肤性病学杂志,2003,17(3):167-168
[24]徐娟,贾随旺,钟绮丽,等.银屑病皮损细胞凋亡的研究.岭南皮肤性病科杂志,2004 11(2):91-93。
[25]SkovL,Baadsgaard O.Bacterial superantigens and inflammatory skin diseases.Clin Exp Dermatol,2000,25(1):57-61.
[26]王丽,焦国梅,赵跃芹等.银屑病患者活血化疲药物治疗前后血液流变学观察.临床皮肤科杂志,1998,02,15:27(1):33-34
[27]秦万章.现代中医药应用与研究大系一皮肤科.上海:上海中医药大学出版社,1994,225
[28]何众玲.银屑病发病机制的神经免疫研究进展北京医科大学学报,2000,32(4):362-365
[29]杨雪琴,张力军,李铀等.生物反馈治疗银屑病的应用研究北京生物医学工程,2003,22(4):290
[30]杨维玲,孙丽梅,张峰等.寻常型银屑病诱发因素分析,中华临床医药杂志,2003.4(1):16-19。
[31]葛宏松,杨森,李明等.银屑病患者居住环境及饮用水类型与其发病的流行病学研究,安徽医科大学学报2002,37(6):447-450
[32]Suttera SP,Qian ZF,Boylan CW.Effects of there Chinese medical herbs on RBC deform ability[J].Clin He Morrheol,2001,71(6):773.
[33]崔健,施松善,王顺春等.白花蛇舌草的化学成分及药理作用研究进展[J].上海中医药杂志,2005,39(7):57-59.
[34]高章图,张建新,徐铎等.甘草酸抗炎抗病毒及免疫调节作用研究进展.解放军药学学报,1999:15(5):27.
[35]李光华,周旭,贺弋等.龙骨免疫作用的实验研究.江苏中医药,2003,24(4):54-55
[36]王法权.郑卫东.马春玲等.合欢皮对小鼠免疫功能的调节作用.临沂医专学报,2000,22(3):201.
[37]李茹,丁安伟,孟丽.女贞子多糖的免疫调节作用研究.中药药理与临床.2001,17(2):11-12。
[38]王德仁.齐墩果酸研究新进展.天津药学,2003,15(3):56-58
[39]李明.甘草的研究概况.甘肃中医学院学报,2000:17(3):59-63
[40]杨骥,张毅,杨雪.白鲜皮对急性微循环障碍大鼠血管内皮分泌的细胞因子 和黏附分子表达的影响.中国中西医结合皮肤性病学杂志2006年第5卷第2期,80-82
[41]黄海英,彭新君,彭延吉.僵蚕的现代研究进展[J].湖南中医学院学报,2003,23(4):62
[42]赵润生,张一昕,苗冬雪等.生地黄对血瘀模型大鼠血液流变性的影响.中药药理与临床,2006,22(3、4):12
[43]毛宏德.白僵蛹中白僵菌素的分离和鉴定[J].中草药,1985,7;5-6.
[44]李仲兴,王秀华,岳云升等紫荆皮对336株临床菌株的体外抗菌活性的研究,中国中医药科技[J],2000.7卷6期,391-392
[45]杜程芳,杨欣欣,屠鹏飞.白鲜皮的化学成分研究[J].中国中药杂志,2005,30(21):1663-1666.
[46]王嵩.中草药抗细菌感染的研究[J].北京中医杂志,2002,21(4):249-251.
[47]路又璐,秦建中.17味中药对培养的表皮细胞增殖的影响[J].临床皮肤科杂志,1996,25(4):202.
[48]乐杰主编.妇产科学.第四版.北京:人民卫生出版社,1980;19
[49]卫功庆,鞠贵春,李慧萍.白僵蚕化学成分的分析[J].吉林农业大学学报,1995,17(3):46
[50]李国均.中国药材学[M].北京:中国医药科技出版社,1996.1997.
[51]蓝昆山,王秀琴等.现代临床中药学[MI.北京:中国中医药出版社.1998:78-554
[52]雷载权,张廷模.中华临床中药学[M].北京:人民卫生出版社,1998.315,1474
[53]董映枢.合欢皮治疗失眠小议[J].浙江中医杂志,1988,23(9):424
[1]Wiegand UW,Chou RC.Pharmacokinetics of acitretin and etretinate[J].J Am Acad Dermatol,1998,39(2 Pt 3):S25 - 33
[2]马成林.银屑病治疗进展.中国全科医学,2001,4(11):847
[3]Kumar B,Saraswat A,Kaur I.Rediscover2ing hydroxyurea:its role in recalcitrant psoriasis[J].Invt J Dermatol,2001,40(8):530 - 534.
[4]Robertshaw H.Friedmann PS.Pioglitazone:a promising therapy for psoriasis.Br JDermatolo 2o05.152:189-91.
[5]Bongartz T,Coras B,Vogt T,et al.Treatment of active psoriatic arthritiswith the PPAR gammaligan d pioglitazone:an open-label pilot study.Rheumatology(Oxford),2005,44:126-129
[6]Lebwohl M.A clinician' s paradigm in the treatment of psoriasis.J Am Acad Dermatol.2005.53(1Suppll):S59-69.
[7]Smith CH.Anstey AV,Barker JN,et al.British Association of Dermatologists guidelines for lIse of biological interventions in psoriasis 2005.Br J Darmatol.2005.153:486497.
[8]KooJ.Khera P.Update on the mechanisms and efficacy ofbiological therapies for psoriasis.J Dermatol Sci.2005.38:75-87.
[9]Mease PJ.Psoriatic arthritis therapy advances.Chit Opin Rheumatol.2005.17:426-432.
[10]Gottlieb AB.Therapeutic options in the treatment of psoriasis and atopic dermatitis,JAm Acad Dermatol,2005.53(1Suppl 1):S3-16.
[11]Stein L.Clinical studies of a new vehicle formulation for topical corticosteroids in the treatment of psoriasis.J Am Acad Dermatol,2005.53(1Suppl1):S39-49.
[12]Remitz A,Reitamo S,Erkko P,et al.Tacrolimus ointment improves psoriasis in amicroplaque assay[J].Br J Dermatol,1999,141(1):103-107.
[13]Gottlieb AB.Therapeutic options in the treatment of psoriasis and atopic dermatitis,JAm Acad Dermatol,2005.53(1 Suppl 1):S3-16.
[14]Gwendoline K.Atopic dermatitis is associated with a decrement in healthrelated quality of life.Inter J Dermatal 2002;41(2):151-158.
[15]王雅娟,董西林,陈琪等.活血通络汤治疗寻常型银屑病80例陕西中医,2002:23(9):796
[16]陈苏.消银方治疗银屑病,山东中医杂志,1998.17(11):500
[17]李寿甫,杨占魁,韩世荣.脏腑辨证分型治疗银屑病1000例,陕西中医,1998:19(2):60
[18]华刚.辨证论治银屑病78例,,四川中医,2003年第21卷第5期:61-62
[19]李茂兴等.从“血”论治银屑病376例疗效观察.四川中医,1993,6:43-44
[20]高志学.银屑病六型辨治初探.陕西中医,1995,16(5):214-215
[21]张晓红,瞿幸,牛福林等.消银解毒饮对银屑病患者白介素8的影响.中华皮肤科杂志,2000:33(2):124.
[22]娄卫海,张志礼,邓丙戎等凉血活血汤治疗进行期银屑病的临床及实验研究,中华皮肤科杂志1999:32(2):80-81
[23]候素春,刘晓明,宋智琦等.凉血活血复方治疗银屑病.中华皮肤科杂志2003.6第36卷第6期352-353
[24]张武一,王萍.凉血解毒汤治疗进行期寻常型银屑病的疗效观察.现代中西医结合志.2007 Feb.16(6)764-765
[25]孙国强,朱风梅.润燥凉血汤治疗银屑病进行期的临床研究,四川中医,2007年第25卷第2期:92
[26]王萍,张凡,李伟凡等.凉血活血汤治疗寻常型银屑病临床观察及TNF-α水平检测[J].中国皮肤性病学杂志,2001,23(3):20
[27]杨志波,向亚萍,欧阳恒.银屑病患者口服竹黄颗粒剂前后血清白介素6和肿瘤坏死因子水平的比较[J].中华皮肤科杂志,2000,33(6):423
[28]林瑞奋,肖明辉,王斗训.三藤汤治疗寻常型银屑病临床及免疫学研究[J].福建中医学院学报,2000,10(3):8-10
[29]林春爱.雷公藤片治疗寻常型银屑病78例.中国皮肤性病学杂志,1995:9(3):175
[30]周辉,刘桂卿.银屑宁治疗银屑病187例疗效观察.贵阳中医学院杂志,200022(1):31
[31]卢庆芳,孙庆海.复方青黛胶囊与复方青黛丸治疗银屑病比较.中国新药与临床杂志,1999,18(4):250
[32]刘晓明,齐欣,宋智琦等.黄芪注射液治疗银屑病患者的临床观察和实验研究[J].中华皮肤科杂志,2001,34(2):113-114
[33]严志福.话血通络胶囊治疗寻常型银屑病50例疗效观察.临床皮肤科杂志,1996.25(4):245
[34]王宝庭,李学军.生脉注射液治疗银屑病的疗效观察.华西医学杂志,2000,15(1):69
[35]周书岭,朱秀华.耳穴划痕治疗银屑病52例体会.山东医药,2003,43(4):778
[36]梁静涛,宋旭明,廖方正.针刺背俞穴辅以局部灸法治疗银屑病的疗效观察,四川中医.2007年第25卷第5期,105
[37]周志勇,汤成波.针刺治疗银屑病12例.安徽中医临床杂志,2003,15(5):385
[38]褚静.井穴刺血加灸疗治疗银屑病30例.黑龙江中医药,2002,(6):42
[39]田元生.经络全息联合疗法治疗银屑病36例疗效观察.中国针灸,2001,21(7):387
[40]张希平.埋线联合复方青黛丸治疗银屑病88例.医药论坛杂志,2003,24(20):60
[41]缪奇祥.贴棉灸治疗银屑病32例[J].上海针灸杂志,1998,17(1):25.
[42]石桂华,郑建寅,罗铁阳.蜂针配合矿泉浴治疗关节型银屑病[J].中华皮肤科杂志,1997,30(5):346-347
[43]刘群英,钟以泽,陈德华,翁孟武.白疙软膏治疗银屑病的实验研究,广西医科大学学报,2006 Jun;23(3):421
[44]宋坪,颜志芳,许铣,刘瓦利.复方莪倍软膏治疗斑块状银屑病的临床观察,中国中西医结合杂志2007年4月第27卷第4期:352-354
[45]王鹏,高瑾,迪丽努尔等,冰黄肤乐软膏治疗银屑病疗效观察,中国皮肤性 病学杂志2006年12月第20卷第12期
[46]张立新,杨顶权,宋佩华等.普连膏在银屑病治疗中的应用.中医外治杂志,2000,9(5):22-23
[47]陈力,徐丽霞.加味黄芩膏在治疗银屑病中的应用.南京中医药大学学报,2003,19(3):180-181
[48]王东海,陈君霞.平银糊膏敷脐治疗银屑病118例.中医外治杂志,1999,8(3):4
[49]刘卫兵、荆鲁华,谢安莉等.综合疗法治疗银屑病疗效观察.人民军医,2001:44(1):53-54.
[50]王爱民,杨斌刘巧,王玲等.复方甘草酸苷联合窄谱中波紫外线照射治疗寻常性银屑病疗效观察临床皮肤科杂志,2007年36卷第5期,332-333
[51]彭才智,胡贤忠,鲁英等.美能联合窄谱UVB治疗寻常型银屑病疗效观察[J].中国误诊学杂志,2006,6(13):2486-2487.
[52]刘辉,罗平,储利亚.复方甘草酸苷联合卡介菌多糖核酸治疗银屑病疗效观察,中国皮肤性病学杂志,2007年3月第2l卷第3期,192-193
[53]杨素清,闫景东,李志鸿.中药四联综合疗法治疗寻常型银屑病初探,辽宁中医杂志2006年第33卷第7期:843-844
[54]俞利靓,潘祥龙.中西药治疗银屑病96例的疗效和生活质量分析,上海中医药杂志2007年第41卷第1期:43-44
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