中药硬膏外敷对膝骨性关节炎主要症状缓解效果的临床观察
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摘要
目的
通过临床实验观察中药硬膏外敷治疗膝关节骨性关节炎的临床疗效。经中药硬膏外敷治疗后观察膝关节骨性关节炎主要临床症状的缓解情况,初步阐明中药硬膏外敷对膝关节骨性关节炎的临床疗效,为中医药外治法临床治疗膝关节骨性关节炎提供一定的临床依据,探讨膝关节骨性关节炎较好的治疗方法。
方法
本实验选取符合标准的病例45例(膝),使用平行对照实验设计,其中实验组(中药硬膏外敷治疗组)22膝和对照组(关节腔注射施沛特治疗组)23膝,记录其主要临床表现(疼痛、肿胀、膝关节屈伸活动障碍)。给予实验组自制中药硬膏外敷,2次/天,连续3次。给予对照组关节腔注射施沛特1支,6天后再观察记录各病例主要临床表现缓解情况。数据用均数±标准差(X±S)表示,计数资料采用χ2检验,计量资料采用t检验,应用SPSS 11.0统计软件分析(设P<0.05为差异具有统计学意义),得出结论。
结果
1、实验组总有效率86.96%,对照组总有效率72.73%,两组比较有显著性差异(P<0.05)；
2、实验组疼痛指数平均下降67.17%,对照组疼痛指数平均下降50.67%,与治疗前比较有显著性差异(P<0。01)；
3、实验组肿胀程度平均下降3.12%,对照组肿胀程度平均下降1.96%,与治疗前比较有显著性差异(P<0.01)；
4、实验组关节活动缓解程度平均好转13.01%,对照组关节活动缓解程度平均好转16.29%,与治疗前比较有显著性差异(P<0.01)。
结论
中药硬膏外敷治疗膝关节骨性关节炎显现出较好的临床疗效,可以明显改善膝关节骨性关节炎的临床症状,特别是在缓解疼痛,消除肿胀和改善膝关节功能活动方面,其治疗效果与关节腔注射玻璃酸钠接近。虽然关节腔注射玻璃酸钠为国际常用的治疗膝关节骨性关节炎的方法,玻璃酸钠作为黏性补充剂关节腔内注射可缓解关节疼痛,具有增加关节润滑作用,但其价格贵,临床操作较复杂,而且属于有创操作,有关节腔感染风险存在,使得其在临床上的应用受到限制。中药硬膏外敷治疗效果肯定,具有消肿止痛、活血化瘀、舒经活络的功能,能改善局部组织血液循环,缓解疼痛引起的肌肉紧张,促进炎症的吸收,而且操作简单,起效较快,疗程短,安全无不良反应,价格低廉,患者易于接受,适合推广于临床使用。
Objective
Observe the effect of clinical trials through the hard Plaster treatment of knee arthritis in clinical efficacy. The external treatment of knee osteoarthritis were observed mainly in the remission of clinical symptoms, the initial stated hard Plaster medicine osteoarthritis of the knee mechanism of clinical efficacy, and of clinical treatment of knee osteoarthritisto provide relevant theoretical and experimental basis.
Methods
In our study,45 cases of standard cases (knee), design of a parallel control experiment, the experimental group (Chinese hard Plaster treatment group) of 22 knees and the control group (intra-articular injection Sofastin treatment group) and 23 knees, record the mainclinical manifestations (pain, swelling, kneeflexionandextensionactivities). Chinese-m ade experimental group given the hard Plaster,2 times/day for 3 times. Control group given intra-articular injection Sofastin, observed and recorded 6 days after clinical remission of the cases are mainly, according to the clinical efficacy, the use of SPSS 11.0 statistical software, measurement data using mean±standard deviation (X±S), said countdata using x 2 test (based P<0.05 was considered statistically significant).
Results
the efficiency of the treatment group was 86.96%in the control group, the total efficiency of 72.73%, compared the two groups was significant difference (P<0.05);The treatment of pain index decreased 67.17% in the control group pain index dropped 50.67% on average, compared with before treatment there was significant difference (P<0.01); Swelling degree of the treatment group decreased 3.12%, swelling the control group decreased 1.96%, compared with before treatment there was significant difference (P<0.05); Treatment group, the average degree of remission of motion improved 13.01% in the control group the average degree of remission of motion improved 16.29%, compared with before treatment there was significant difference (P<0.01).
Conclusion
Hard Plaster TCM treatment of knee osteoarthritis showing better clinical efficacy, can improve the clinical knee osteoarthritis symptoms, especially in pain relief, reduce swelling and improve knee function activities, and its treatmentand intra-articular injection of sodium hyaluronate close. Although intra-articular injection of sodium hyaluronate for the treatment of the international common method of osteoarthritis of the knee, as the viscosity of sodium hyaluronate intra-articular injection of supplements can relieve joint pain, with increasing joint lubrication, but its expensive, clinicalmore complicated operation, but is an invasive operation, there exists the risk of infection after joint cavity, so its clinical application is limited. TCM treatment is effective for hard-Plaster, with swelling and pain, blood circulation, Shu by active.features, local organizations can improve blood circulation, relieve pain caused by muscle tension, promote the absorption of inflammation, but also simple, rapid onset, short course of treatment, safe and adverse reactions, low cost, easily accepted by patients, for promotion in clinical use.
通过临床实验观察中药硬膏外敷治疗膝关节骨性关节炎的临床疗效。经中药硬膏外敷治疗后观察膝关节骨性关节炎主要临床症状的缓解情况,初步阐明中药硬膏外敷对膝关节骨性关节炎的临床疗效,为中医药外治法临床治疗膝关节骨性关节炎提供一定的临床依据,探讨膝关节骨性关节炎较好的治疗方法。
方法
本实验选取符合标准的病例45例(膝),使用平行对照实验设计,其中实验组(中药硬膏外敷治疗组)22膝和对照组(关节腔注射施沛特治疗组)23膝,记录其主要临床表现(疼痛、肿胀、膝关节屈伸活动障碍)。给予实验组自制中药硬膏外敷,2次/天,连续3次。给予对照组关节腔注射施沛特1支,6天后再观察记录各病例主要临床表现缓解情况。数据用均数±标准差(X±S)表示,计数资料采用χ2检验,计量资料采用t检验,应用SPSS 11.0统计软件分析(设P<0.05为差异具有统计学意义),得出结论。
结果
1、实验组总有效率86.96%,对照组总有效率72.73%,两组比较有显著性差异(P<0.05)；
2、实验组疼痛指数平均下降67.17%,对照组疼痛指数平均下降50.67%,与治疗前比较有显著性差异(P<0。01)；
3、实验组肿胀程度平均下降3.12%,对照组肿胀程度平均下降1.96%,与治疗前比较有显著性差异(P<0.01)；
4、实验组关节活动缓解程度平均好转13.01%,对照组关节活动缓解程度平均好转16.29%,与治疗前比较有显著性差异(P<0.01)。
结论
中药硬膏外敷治疗膝关节骨性关节炎显现出较好的临床疗效,可以明显改善膝关节骨性关节炎的临床症状,特别是在缓解疼痛,消除肿胀和改善膝关节功能活动方面,其治疗效果与关节腔注射玻璃酸钠接近。虽然关节腔注射玻璃酸钠为国际常用的治疗膝关节骨性关节炎的方法,玻璃酸钠作为黏性补充剂关节腔内注射可缓解关节疼痛,具有增加关节润滑作用,但其价格贵,临床操作较复杂,而且属于有创操作,有关节腔感染风险存在,使得其在临床上的应用受到限制。中药硬膏外敷治疗效果肯定,具有消肿止痛、活血化瘀、舒经活络的功能,能改善局部组织血液循环,缓解疼痛引起的肌肉紧张,促进炎症的吸收,而且操作简单,起效较快,疗程短,安全无不良反应,价格低廉,患者易于接受,适合推广于临床使用。
Objective
Observe the effect of clinical trials through the hard Plaster treatment of knee arthritis in clinical efficacy. The external treatment of knee osteoarthritis were observed mainly in the remission of clinical symptoms, the initial stated hard Plaster medicine osteoarthritis of the knee mechanism of clinical efficacy, and of clinical treatment of knee osteoarthritisto provide relevant theoretical and experimental basis.
Methods
In our study,45 cases of standard cases (knee), design of a parallel control experiment, the experimental group (Chinese hard Plaster treatment group) of 22 knees and the control group (intra-articular injection Sofastin treatment group) and 23 knees, record the mainclinical manifestations (pain, swelling, kneeflexionandextensionactivities). Chinese-m ade experimental group given the hard Plaster,2 times/day for 3 times. Control group given intra-articular injection Sofastin, observed and recorded 6 days after clinical remission of the cases are mainly, according to the clinical efficacy, the use of SPSS 11.0 statistical software, measurement data using mean±standard deviation (X±S), said countdata using x 2 test (based P<0.05 was considered statistically significant).
Results
the efficiency of the treatment group was 86.96%in the control group, the total efficiency of 72.73%, compared the two groups was significant difference (P<0.05);The treatment of pain index decreased 67.17% in the control group pain index dropped 50.67% on average, compared with before treatment there was significant difference (P<0.01); Swelling degree of the treatment group decreased 3.12%, swelling the control group decreased 1.96%, compared with before treatment there was significant difference (P<0.05); Treatment group, the average degree of remission of motion improved 13.01% in the control group the average degree of remission of motion improved 16.29%, compared with before treatment there was significant difference (P<0.01).
Conclusion
Hard Plaster TCM treatment of knee osteoarthritis showing better clinical efficacy, can improve the clinical knee osteoarthritis symptoms, especially in pain relief, reduce swelling and improve knee function activities, and its treatmentand intra-articular injection of sodium hyaluronate close. Although intra-articular injection of sodium hyaluronate for the treatment of the international common method of osteoarthritis of the knee, as the viscosity of sodium hyaluronate intra-articular injection of supplements can relieve joint pain, with increasing joint lubrication, but its expensive, clinicalmore complicated operation, but is an invasive operation, there exists the risk of infection after joint cavity, so its clinical application is limited. TCM treatment is effective for hard-Plaster, with swelling and pain, blood circulation, Shu by active.features, local organizations can improve blood circulation, relieve pain caused by muscle tension, promote the absorption of inflammation, but also simple, rapid onset, short course of treatment, safe and adverse reactions, low cost, easily accepted by patients, for promotion in clinical use.
引文
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