补肾解毒通络汤治疗消渴肾病（气阴两虚兼瘀毒证）的临床研究
|
摘要
目的:为观察补肾解毒通络汤治疗消渴肾病气阴两虚兼瘀毒证的临床疗效。
方法:取符合消渴肾病气阴两虚兼瘀毒证诊断标准的患者60例,随机分成2组。治疗组30例,予补肾解毒通络汤加减水煎取汁120ml一次1剂,一日四次,三餐后20分钟及睡前口服。对照组30例,予金水宝胶囊(由冬虫夏草提取物组成)一次1.98g,一日3次口服。治疗组与对照组均以一个月为一个疗程,连续观察两个疗程。两组间在病程、年龄、性别上经统计处理无差异,具有可比性。观察2组治疗前后理化检查及临床症状改善情况。
结果:结果表明治疗组显效率53.33%,总有效率73.33%;对照组显效率23.33%,总有效率56.6%,经统计学处理,P<0.05,具有显著性差异,说明治疗组疗效明显优于对照组。治疗后对于病人血糖情况,如空腹血糖,餐后2小时血糖,尿常规有较好的改善,与治疗前相比P<0.01,与对照组相比P<0.01。均具有极显著性差异,说明治疗组对于改善血糖情况优于对照组;治疗组对于患者尿常规情况与治疗前相比P<0.01与对照组相比P<0.05,有显著性差异,说明补肾解毒通络汤对于改善患者血糖及尿常规情况优于金水宝胶囊组。
结论:补肾解毒通络汤在临床症状及各种理化检查结果等方面均优于金水宝胶囊,未见不良反应,说明补肾解毒通络汤安全可靠,是治疗消渴肾病气阴两虚兼瘀毒证的有效方剂,值得进一步开发和研究。
Purpose: To observe the kidney detoxification Tongluo kidney Qi and Yin Deficiency Treatment of Diabetes and Clinical permit Ecchymosis.
Method: Consistent with diabetes and kidney Qi and Yin Deficiency take Ecchymosis card diagnostic criteria 60 patients were randomly divided into 2 groups. Treatment group 30 cases, to kidney detoxification Tongluo Decoction juice 120ml water to cook the first one, day four, 20 minutes after meals and at bedtime orally. Control group of 30 patients, to Jinshuibao capsule (composed by the Cordyceps sinensis extract) a 1.98g, 3 times a day orally. Treatment group and control group are in a month for a course of treatment, continuous observation of two courses. Between the two groups in the course of the disease, age, gender no difference by statistical treatment, comparable. Observed before and after treatment 2 Physical examination and clinical symptoms.
Result: The results show that the efficiency of the treatment group was 53.33%, total effective rate was 73.33%; control group was 23.33%, 56.6% total efficiency, the statistical analysis, P <0.05, significant difference, indicating significantly better than the control treatment group group. Glucose metabolism after treatment for the patient, including fasting blood glucose, postprandial 2 h blood glucose, urine had a better outcome, compared with that before treatment P <0.01, compared with control group P <0.01. All have a very significant difference, indicating that the treatment group for improving the glucose metabolism than the control group; Urine treatment group for patients before treatment compared to the situation with P <0.01 compared with control group P <0.05, significant difference, indicating that kidney detoxification Tongluo soup for improving glucose metabolism and urine of patients was better than Jinshuibao Capsule group.
Conclusion: Tong Luo Tang kidney detoxification clinical symptoms and physical and chemical test results were better than Jinshuibao capsule, no adverse reactions, indicating that kidney detoxification soup safe and reliable communication network is the treatment of diabetes kidney Qi and Yin Deficiency and Blood Stasis effective prescription drug card, it is worth further development and research
方法:取符合消渴肾病气阴两虚兼瘀毒证诊断标准的患者60例,随机分成2组。治疗组30例,予补肾解毒通络汤加减水煎取汁120ml一次1剂,一日四次,三餐后20分钟及睡前口服。对照组30例,予金水宝胶囊(由冬虫夏草提取物组成)一次1.98g,一日3次口服。治疗组与对照组均以一个月为一个疗程,连续观察两个疗程。两组间在病程、年龄、性别上经统计处理无差异,具有可比性。观察2组治疗前后理化检查及临床症状改善情况。
结果:结果表明治疗组显效率53.33%,总有效率73.33%;对照组显效率23.33%,总有效率56.6%,经统计学处理,P<0.05,具有显著性差异,说明治疗组疗效明显优于对照组。治疗后对于病人血糖情况,如空腹血糖,餐后2小时血糖,尿常规有较好的改善,与治疗前相比P<0.01,与对照组相比P<0.01。均具有极显著性差异,说明治疗组对于改善血糖情况优于对照组;治疗组对于患者尿常规情况与治疗前相比P<0.01与对照组相比P<0.05,有显著性差异,说明补肾解毒通络汤对于改善患者血糖及尿常规情况优于金水宝胶囊组。
结论:补肾解毒通络汤在临床症状及各种理化检查结果等方面均优于金水宝胶囊,未见不良反应,说明补肾解毒通络汤安全可靠,是治疗消渴肾病气阴两虚兼瘀毒证的有效方剂,值得进一步开发和研究。
Purpose: To observe the kidney detoxification Tongluo kidney Qi and Yin Deficiency Treatment of Diabetes and Clinical permit Ecchymosis.
Method: Consistent with diabetes and kidney Qi and Yin Deficiency take Ecchymosis card diagnostic criteria 60 patients were randomly divided into 2 groups. Treatment group 30 cases, to kidney detoxification Tongluo Decoction juice 120ml water to cook the first one, day four, 20 minutes after meals and at bedtime orally. Control group of 30 patients, to Jinshuibao capsule (composed by the Cordyceps sinensis extract) a 1.98g, 3 times a day orally. Treatment group and control group are in a month for a course of treatment, continuous observation of two courses. Between the two groups in the course of the disease, age, gender no difference by statistical treatment, comparable. Observed before and after treatment 2 Physical examination and clinical symptoms.
Result: The results show that the efficiency of the treatment group was 53.33%, total effective rate was 73.33%; control group was 23.33%, 56.6% total efficiency, the statistical analysis, P <0.05, significant difference, indicating significantly better than the control treatment group group. Glucose metabolism after treatment for the patient, including fasting blood glucose, postprandial 2 h blood glucose, urine had a better outcome, compared with that before treatment P <0.01, compared with control group P <0.01. All have a very significant difference, indicating that the treatment group for improving the glucose metabolism than the control group; Urine treatment group for patients before treatment compared to the situation with P <0.01 compared with control group P <0.05, significant difference, indicating that kidney detoxification Tongluo soup for improving glucose metabolism and urine of patients was better than Jinshuibao Capsule group.
Conclusion: Tong Luo Tang kidney detoxification clinical symptoms and physical and chemical test results were better than Jinshuibao capsule, no adverse reactions, indicating that kidney detoxification soup safe and reliable communication network is the treatment of diabetes kidney Qi and Yin Deficiency and Blood Stasis effective prescription drug card, it is worth further development and research
引文
[1] IDF,《Diabetes Atlas》,第3版
[2]赵进喜,邓德强,李靖.糖尿病肾病相关中医病名考辨[J].南京中医药大学学报, 2005, 21(5): 288
[3]任爱华,阚方旭.糖尿病肾病三焦辨治[J].山东中医杂志, 2000,19(6): 328
[4]南征.消渴肾病(糖尿病肾病)研究[M].长春:吉林科学出版社,2001. 3
[5]赵迪,高彦彬教授治疗糖尿病肾病学术思想和经验.中医研究,2007,1,20(1):42-44
[6]朴春丽,姜喆,南征,从毒损肾络探讨糖尿病肾病炎症发病机制.山东中医药杂志,2004,10,23(10):582-583
[7]赵晓山,罗仁,吕建勇,等·肾虚型糖尿病肾病患者尿白蛋白排泄变化规律的研究[J].中华实用中西医杂志,2004,004(004):567~568
[8]张庚良,糖尿病肾病的辨证治疗.河北中医,2005,8,27(8):594
[9]刘素荣,程益春教授治疗糖尿病肾病用药特色.中国中医药信息杂志,2004,11,11(11):1017
[10]韩彬,兰红勤.旷惠桃教授论治糖尿病肾病经验,中医药导报,2007,7,13(7):16
[11]耿嘉,王丹,朴胜华,栗德林.栗德林教授辨治糖尿病肾病的学术思想简介,中国中西医结合肾病杂志,2005,5,6(5):253
[12]朱昭明,平阳,吴以岭,糖尿病肾病病变特点探讨.中医药管理杂志,2006,3,14(3):51
[13]赵会贤,苏荣华,高新业,糖尿病肾病的病因病机及证治浅识.中医药学刊,2004.9,22:1760
[14]黄学民,赵进喜.糖尿病肾病的中医分期分型辨证探讨[J].中国老年保健医学,2005,3(1):28
[15]吴以岭,魏聪,贾振华,等.从络病学说论治糖尿病肾病[J].疑难病杂志,2007,6,6(6):350.
[16]张水生,赵贤俊,糖尿病肾病的中医病名及病因病机探析.辽宁中医杂志,2006,33(12):1575
[17]朴春丽,王秀阁,杨世忠.龙胆泻肝汤加减治疗Ⅳ期糖尿病肾病30例临床研究[J].山东中医杂志, 2004, 23(12): 714
[18]黄绪平,王漫丽,刘伟.健脾益肾活血法治疗糖尿病肾病,黑龙江中医药,2007,(3):30
[19]林莹宣,张静,曾静,亓鲁光治疗糖尿病肾病经验撷要.山西中医,2009,1,25(1):6
[20]周英、蓝柳贵等.彭万年教授治疗糖尿病肾病经验介绍[J].新中医,2007,39(1):69-70
[21]王秀珍.健脾固肾汤治疗早期糖尿病肾病40例[J].浙江中医杂志, 2004, 39(8): 332
[22]王晓光,王亚丽,张琪,张琪教授治疗糖尿病肾病经验.陕西中医,2004,25(12):1116
[23]卞镝,李敬林,董天宝,从瘀论治糖尿病肾病.辽宁中医杂志,2006,33(10):1266-1267
[24]刘喜明.试论消渴病临床面貌与概念的变化[J].世界中西医结合杂志,2007,2(4):187.
[25]南征.消渴肾病(糖尿病肾病)研究[M].长春:吉林科学出版社,2001.254.
[26]任继学.任继学经验集[M].北京:人民卫生出版社,2000.5.
[27]李雷.从络病论治糖尿病肾病.浙江中医杂志,2007,5,42(5):258
[28]倪斌.糖尿病肾病的本虚证研究[J].江苏中医药,2005,26(6):13.
[29]肖永华,吕仁和治疗糖尿病肾病经验,世界中医药,2007,5,2(3):151
[30]张星,许筠.糖尿病肾病不同疗法疗效对比观察[J]·中西医结合肾病杂志, 2007,8(1): 45~46
[31]吴家渝·辨证分型治疗糖尿病肾病58例[J]·中医药学刊, 2006,24(9): 1716·
[32]李桂芝,郑万发.中医辨证治疗糖尿病肾病100例疗效观察[J].云南中医中药杂志,2007,28(1):17
[33]姚文彦,史耀勋,田谧,消渴肾病证治心得,长春中医药大学学报,2008,6,24(3):286
[34]南劲松等.南征医学文集[M].长春:长春出版社,2008.185.
[35]仝小林,糖尿病中医防治指南解读.第1版.北京:中国中医药出版社,2009.63
[36]张珍先.糖尿病肾病的辨证论治[J].光明中医,2006, 21 (1):16
[37]南征,高彦彬,钱秋海.糖尿病中西医综合治疗.第1版.北京:人民卫生出版社,2002.325.
[38]马影,杨娜,南征,化浊益肾解毒汤主治消渴肾病30例研究.吉林中医药,2005,2,25(2):10
[39]湛洁,苏经格·益气养阴活血方治疗糖尿病肾病30例临床研究[J]·中医杂志, 2006, 47(11): 841~843·
[40]宋宗良,姜菊娥·中西医结合治疗早期糖尿病肾病48例临床研究[J]·四川中医, 2007, 25(2): 76~77·
[41]南征,孙新宇,赵贤俊,等.益肾解毒汤治疗糖尿病肾病的临床研究.北京中医杂志,2002,21(6):326-328.
[42]王锁欣.平消安肾汤治疗早期糖尿病肾病58例[J].陕西中医,2005, 26(12): 1284—1285
[43]王小超,刘克冕,胡咏新,冯栋年,消渴肾安治疗糖尿病肾病54例疗效观察.新中医,2007,2,39(2):70
[44]罗燕,消渴汤二号配合金水宝胶囊治疗糖尿病肾病犯例疗效观察,新中医2006,4,38(4):44
[45]李宏春·苦芪方治疗糖尿病肾病及对血糖血脂影响的临床研究[J].新中医,2006,38(2):36~38·
[46]刘克冕,王小超,狄红杰,谢绍锋,消渴肾康汤联合贝那普利治疗早期糖尿病肾病临床研究.实用中医药杂志,2009,1,25(1):26
[47]张振忠,豆小妮,赵宏波,马丽娟,参芪糖肾安胶囊治疗糖尿病肾病的动物实验研究,现代中医药,2007,5,27(3):69
[48]刘圣,唐丽琴,陈象青,陈礼明,张善堂,魏瑜,复方黄连胶囊对大鼠糖尿病肾病及血液流变学异常的干预作用,中草药, 2008,7,39(7):1044
[49]赵丹阳,岳超,麦地消渴汤治疗早期糖尿病肾病的临床研究.中医药信息,2004,21(5):44
[50]李玉忠,孔祥英,卢笑晖.补肾固精法治疗早期糖尿病肾病60例,山东中医药大学学报,2005,29(4):289-290.
[51]陈辉,汤永福·活血化瘀法治疗早期糖尿病肾病及其对肾血流参数的影响[J]·中国中西医结合肾病杂志2005, 6(1): 31~32·
[52]黄耀先.活血化瘀法治疗糖尿病肾病47例[J].山西中医2007,23(2):20—21
[53]钱秋海,李红专,冯乐燕·糖肾宁治疗早期糖尿病肾病机制探讨[J].山东中医杂志,2005,24(5):262~264·
[54]尹卫华,夏红梅,宋雅琴.益气滋阴活血化瘀法治疗早期糖尿病肾病30例[J].江西中医药,2005,(1):30
[55]陈景亮,凌方明.六味地黄丸对早期糖尿病肾病尿微量白蛋白的影响[J].新中医, 2004, 36(12): 26-27.
[56]张金玉,仝霞,六味地黄丸治疗糖尿病肾病40例.中国民间疗法,2006,4,14(4):45
[57]郑丽霞,王光玮,黄志良,六味地黄丸治疗2型糖尿病肾病51例.河南中医,2008,8,28(8):20
[58]王爱军.补阳还五汤加减治疗早期糖尿病肾病疗效观察[J].四川中医,2007,25(4):67
[59]杨小翠,徐红·藿朴夏苓汤合玉屏风散治疗肥胖型糖尿病肾病的临床观察[J]·河南中医学院学报, 2006, 21(122): 46~47·
[60]廉波,同济肾康胶囊治疗糖尿病肾病265例临床研究,长春中医药大学学报,2006,12,22(4):21—22.
[61]刘丹,刘松,丁红.黄芪注射液治疗糖尿病肾病的疗效观察[J].中国厂矿医学, 2004, (6): 446~447.
[62]冯毅,冯烈·黄芪对糖尿病大鼠肾脏保护作用的机制[J]·实用医学杂志, 2006, 22(21): 2457~2459·
[63]司廷林,侯慧珍.黄芪注射液对早期糖尿病肾病尿微量清蛋白及内皮素的影响[J].山东中医药大学学报, 2007, 31 (1) : 36—37
[64]李长天,陈雁飞·葛根素对糖尿病大鼠肾脏糖基化终产物和转化生长因子-β1表达的影响[J].中国中医药信息杂志,2006,13(3):36~38·
[65]张征宇,孙澎彬.三七总苷注射液辅助治疗早期糖尿病肾病患者的疗效观察.中国中西医结合肾病杂志,2005,6(7):407-409.
[66]杨志刚,陈阿琴,俞颂东·三七药理研究新进展[J].上海中医药杂志, 2005, 39(4): 59~62·
[67]屠庆年,程苏,陆付耳·三七总甙对糖尿病肾病大鼠血栓素B2及6-酮-前列腺素F1α的影响[J].中国中西医结合消化杂志,2005,13(4):253~255·
[68]柳刚,关广聚,亓同钢,等.丹参对糖尿病大鼠肾脏的保护作用及其机制研究[J].中西医结合学报, 2005, 3(6): 459~462.
[69]杨明正,张小如·决明子对糖尿病大鼠肾组织NF-KB活化的影响[J]·浙江中西医结合杂志, 2006, 16(3): 149~150·
[70]史伟,吴金玉,向彩春,等.水蛭注射液治疗糖尿病肾病57例[J].陕西中医2007,28(4):40
[71]南劲松等.南征医学文集[M].长春:长春出版社,2008.286.
[72]赵晓山,罗仁,吕建勇,等·肾虚型糖尿病肾病患者尿白蛋白排泄变化规律的研究[J].中华实用中西医杂志,2004,004(004):567-568.
[2]赵进喜,邓德强,李靖.糖尿病肾病相关中医病名考辨[J].南京中医药大学学报, 2005, 21(5): 288
[3]任爱华,阚方旭.糖尿病肾病三焦辨治[J].山东中医杂志, 2000,19(6): 328
[4]南征.消渴肾病(糖尿病肾病)研究[M].长春:吉林科学出版社,2001. 3
[5]赵迪,高彦彬教授治疗糖尿病肾病学术思想和经验.中医研究,2007,1,20(1):42-44
[6]朴春丽,姜喆,南征,从毒损肾络探讨糖尿病肾病炎症发病机制.山东中医药杂志,2004,10,23(10):582-583
[7]赵晓山,罗仁,吕建勇,等·肾虚型糖尿病肾病患者尿白蛋白排泄变化规律的研究[J].中华实用中西医杂志,2004,004(004):567~568
[8]张庚良,糖尿病肾病的辨证治疗.河北中医,2005,8,27(8):594
[9]刘素荣,程益春教授治疗糖尿病肾病用药特色.中国中医药信息杂志,2004,11,11(11):1017
[10]韩彬,兰红勤.旷惠桃教授论治糖尿病肾病经验,中医药导报,2007,7,13(7):16
[11]耿嘉,王丹,朴胜华,栗德林.栗德林教授辨治糖尿病肾病的学术思想简介,中国中西医结合肾病杂志,2005,5,6(5):253
[12]朱昭明,平阳,吴以岭,糖尿病肾病病变特点探讨.中医药管理杂志,2006,3,14(3):51
[13]赵会贤,苏荣华,高新业,糖尿病肾病的病因病机及证治浅识.中医药学刊,2004.9,22:1760
[14]黄学民,赵进喜.糖尿病肾病的中医分期分型辨证探讨[J].中国老年保健医学,2005,3(1):28
[15]吴以岭,魏聪,贾振华,等.从络病学说论治糖尿病肾病[J].疑难病杂志,2007,6,6(6):350.
[16]张水生,赵贤俊,糖尿病肾病的中医病名及病因病机探析.辽宁中医杂志,2006,33(12):1575
[17]朴春丽,王秀阁,杨世忠.龙胆泻肝汤加减治疗Ⅳ期糖尿病肾病30例临床研究[J].山东中医杂志, 2004, 23(12): 714
[18]黄绪平,王漫丽,刘伟.健脾益肾活血法治疗糖尿病肾病,黑龙江中医药,2007,(3):30
[19]林莹宣,张静,曾静,亓鲁光治疗糖尿病肾病经验撷要.山西中医,2009,1,25(1):6
[20]周英、蓝柳贵等.彭万年教授治疗糖尿病肾病经验介绍[J].新中医,2007,39(1):69-70
[21]王秀珍.健脾固肾汤治疗早期糖尿病肾病40例[J].浙江中医杂志, 2004, 39(8): 332
[22]王晓光,王亚丽,张琪,张琪教授治疗糖尿病肾病经验.陕西中医,2004,25(12):1116
[23]卞镝,李敬林,董天宝,从瘀论治糖尿病肾病.辽宁中医杂志,2006,33(10):1266-1267
[24]刘喜明.试论消渴病临床面貌与概念的变化[J].世界中西医结合杂志,2007,2(4):187.
[25]南征.消渴肾病(糖尿病肾病)研究[M].长春:吉林科学出版社,2001.254.
[26]任继学.任继学经验集[M].北京:人民卫生出版社,2000.5.
[27]李雷.从络病论治糖尿病肾病.浙江中医杂志,2007,5,42(5):258
[28]倪斌.糖尿病肾病的本虚证研究[J].江苏中医药,2005,26(6):13.
[29]肖永华,吕仁和治疗糖尿病肾病经验,世界中医药,2007,5,2(3):151
[30]张星,许筠.糖尿病肾病不同疗法疗效对比观察[J]·中西医结合肾病杂志, 2007,8(1): 45~46
[31]吴家渝·辨证分型治疗糖尿病肾病58例[J]·中医药学刊, 2006,24(9): 1716·
[32]李桂芝,郑万发.中医辨证治疗糖尿病肾病100例疗效观察[J].云南中医中药杂志,2007,28(1):17
[33]姚文彦,史耀勋,田谧,消渴肾病证治心得,长春中医药大学学报,2008,6,24(3):286
[34]南劲松等.南征医学文集[M].长春:长春出版社,2008.185.
[35]仝小林,糖尿病中医防治指南解读.第1版.北京:中国中医药出版社,2009.63
[36]张珍先.糖尿病肾病的辨证论治[J].光明中医,2006, 21 (1):16
[37]南征,高彦彬,钱秋海.糖尿病中西医综合治疗.第1版.北京:人民卫生出版社,2002.325.
[38]马影,杨娜,南征,化浊益肾解毒汤主治消渴肾病30例研究.吉林中医药,2005,2,25(2):10
[39]湛洁,苏经格·益气养阴活血方治疗糖尿病肾病30例临床研究[J]·中医杂志, 2006, 47(11): 841~843·
[40]宋宗良,姜菊娥·中西医结合治疗早期糖尿病肾病48例临床研究[J]·四川中医, 2007, 25(2): 76~77·
[41]南征,孙新宇,赵贤俊,等.益肾解毒汤治疗糖尿病肾病的临床研究.北京中医杂志,2002,21(6):326-328.
[42]王锁欣.平消安肾汤治疗早期糖尿病肾病58例[J].陕西中医,2005, 26(12): 1284—1285
[43]王小超,刘克冕,胡咏新,冯栋年,消渴肾安治疗糖尿病肾病54例疗效观察.新中医,2007,2,39(2):70
[44]罗燕,消渴汤二号配合金水宝胶囊治疗糖尿病肾病犯例疗效观察,新中医2006,4,38(4):44
[45]李宏春·苦芪方治疗糖尿病肾病及对血糖血脂影响的临床研究[J].新中医,2006,38(2):36~38·
[46]刘克冕,王小超,狄红杰,谢绍锋,消渴肾康汤联合贝那普利治疗早期糖尿病肾病临床研究.实用中医药杂志,2009,1,25(1):26
[47]张振忠,豆小妮,赵宏波,马丽娟,参芪糖肾安胶囊治疗糖尿病肾病的动物实验研究,现代中医药,2007,5,27(3):69
[48]刘圣,唐丽琴,陈象青,陈礼明,张善堂,魏瑜,复方黄连胶囊对大鼠糖尿病肾病及血液流变学异常的干预作用,中草药, 2008,7,39(7):1044
[49]赵丹阳,岳超,麦地消渴汤治疗早期糖尿病肾病的临床研究.中医药信息,2004,21(5):44
[50]李玉忠,孔祥英,卢笑晖.补肾固精法治疗早期糖尿病肾病60例,山东中医药大学学报,2005,29(4):289-290.
[51]陈辉,汤永福·活血化瘀法治疗早期糖尿病肾病及其对肾血流参数的影响[J]·中国中西医结合肾病杂志2005, 6(1): 31~32·
[52]黄耀先.活血化瘀法治疗糖尿病肾病47例[J].山西中医2007,23(2):20—21
[53]钱秋海,李红专,冯乐燕·糖肾宁治疗早期糖尿病肾病机制探讨[J].山东中医杂志,2005,24(5):262~264·
[54]尹卫华,夏红梅,宋雅琴.益气滋阴活血化瘀法治疗早期糖尿病肾病30例[J].江西中医药,2005,(1):30
[55]陈景亮,凌方明.六味地黄丸对早期糖尿病肾病尿微量白蛋白的影响[J].新中医, 2004, 36(12): 26-27.
[56]张金玉,仝霞,六味地黄丸治疗糖尿病肾病40例.中国民间疗法,2006,4,14(4):45
[57]郑丽霞,王光玮,黄志良,六味地黄丸治疗2型糖尿病肾病51例.河南中医,2008,8,28(8):20
[58]王爱军.补阳还五汤加减治疗早期糖尿病肾病疗效观察[J].四川中医,2007,25(4):67
[59]杨小翠,徐红·藿朴夏苓汤合玉屏风散治疗肥胖型糖尿病肾病的临床观察[J]·河南中医学院学报, 2006, 21(122): 46~47·
[60]廉波,同济肾康胶囊治疗糖尿病肾病265例临床研究,长春中医药大学学报,2006,12,22(4):21—22.
[61]刘丹,刘松,丁红.黄芪注射液治疗糖尿病肾病的疗效观察[J].中国厂矿医学, 2004, (6): 446~447.
[62]冯毅,冯烈·黄芪对糖尿病大鼠肾脏保护作用的机制[J]·实用医学杂志, 2006, 22(21): 2457~2459·
[63]司廷林,侯慧珍.黄芪注射液对早期糖尿病肾病尿微量清蛋白及内皮素的影响[J].山东中医药大学学报, 2007, 31 (1) : 36—37
[64]李长天,陈雁飞·葛根素对糖尿病大鼠肾脏糖基化终产物和转化生长因子-β1表达的影响[J].中国中医药信息杂志,2006,13(3):36~38·
[65]张征宇,孙澎彬.三七总苷注射液辅助治疗早期糖尿病肾病患者的疗效观察.中国中西医结合肾病杂志,2005,6(7):407-409.
[66]杨志刚,陈阿琴,俞颂东·三七药理研究新进展[J].上海中医药杂志, 2005, 39(4): 59~62·
[67]屠庆年,程苏,陆付耳·三七总甙对糖尿病肾病大鼠血栓素B2及6-酮-前列腺素F1α的影响[J].中国中西医结合消化杂志,2005,13(4):253~255·
[68]柳刚,关广聚,亓同钢,等.丹参对糖尿病大鼠肾脏的保护作用及其机制研究[J].中西医结合学报, 2005, 3(6): 459~462.
[69]杨明正,张小如·决明子对糖尿病大鼠肾组织NF-KB活化的影响[J]·浙江中西医结合杂志, 2006, 16(3): 149~150·
[70]史伟,吴金玉,向彩春,等.水蛭注射液治疗糖尿病肾病57例[J].陕西中医2007,28(4):40
[71]南劲松等.南征医学文集[M].长春:长春出版社,2008.286.
[72]赵晓山,罗仁,吕建勇,等·肾虚型糖尿病肾病患者尿白蛋白排泄变化规律的研究[J].中华实用中西医杂志,2004,004(004):567-568.
© 2004-2018 中国地质图书馆版权所有 京ICP备05064691号 京公网安备11010802017129号 地址：北京市海淀区学院路29号 邮编：100083 电话：办公室：(+86 10)66554848；文献借阅、咨询服务、科技查新：66554700 |