骨质疏松及相关椎体骨折的磁共振功能成像评估
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摘要
第一部分 磁共振波谱成像(MRs)定量评估兔椎体骨髓状况的初步研究
目的：初步探讨兔椎体MRS测量值同相应组织形态学结果的相关性。材料与方法：采用单体素PRESS(Point resolred spectroscopy)序列对15只不同月龄(4～13月，平均8.6±3.2月)健康新西兰雌性白兔行L7椎体MRS采集。波谱分析采用SAGE 7.0波谱分析软件，计算椎体波谱的脂水比(Lipid waterratio，LWR)。MRS采集结束后取出相应扫描椎体，并制作常规HE染色切片，组织切片图像分析采用Image-pro plus 5.0软件，计算黄髓、红髓的面积比。结果：兔椎体MRS显示LWR 0.263～2.594，平均0.881±0.59；组织切片黄、红髓面积比0.114～3.45，平均1.166±0.88，两者相关系数r=0.817(P＜0.01)，直线回归方程LWR=0.24+0.55×黄红髓面积比。结论：椎体MRS同组织形态学结果存在相关性，椎体骨髓中红、黄髓组成比例的变化可以较好地被LWR予以反映，从而为椎体MRS提供了一定的组织形态学基础。
第二部分 骨质疏松及相关椎体骨折的磁共振波谱成像(MRS)评估
目的：探讨椎体~1H MRS测量值同DXA、QCT所测骨密度的相关性及其对骨质疏松及相关椎体骨折的评估价值。材料与方法：共有152例(30～80岁，平均58.2±14.2岁)女性志愿者分别进行以下检查：胸腰椎侧位(T4-L4)平片，并采用Genant半定量法对其进行评阅。腰椎及股骨近端双能X线(DXA)骨密度测量。腰椎定量CT(QCT)骨密度测量。腰椎常规矢状位T_2WI、T_1WI和横轴位T_2WI扫描。
Part one: Pilot study of vertebral bone marrow by MR
Spectroscopy in rabbits
Objective: The aim of the study was to evaluate the relationship between vertebral magnetic resonance spectroscopy (MRS) and histomorphology in rabbits. Materials and methods: A total of fifteen healthy Zelanian rabbits (mean age 8.6 ± 3.2 months, range 4~13months) underwent single voxel (SV) ~1H MRS examination at the lumbar spine (L7) with point resolved spectroscopy (PRESS) sequence. Lipid water ratio (LWR) was measured by SAGE 7.0 software. The vertebral body was dissected after MRS examination. Then the histomorphological slices were stained with H.E method. The Image-pro plus 5.0 software was used to analyze the histomorphological slices and to calculate the ratio of yellow bone marrow area to red bone marrow area in vertebral body. Results: Mean value of LWR of the vertebral body was 0.881±0.59 (range 0.263~2.594). The mean yellow/red bone marrow ratio from histomorphological slices was 1.166±0.88 (range 0.114~ 3.457). A positive correlation was found between LWR and area ratio (r=0.817,P<0.01). The linear regression equation from the correlation was obtained (LWR=0.24+0.55 × area ratio). Conclusion: LWR could partially reflect the yellow/red bone marrow ratio in vertebral body. The changes of vertebral bone marrow could provide a histomorphological basis for the vertebral MRS.
Part two: Potential value of vertebral proton MR Spectroscopy
in determining osteoporosis and vertebral fracture
Objective: To investigate the correlation between vertebral proton
目的：初步探讨兔椎体MRS测量值同相应组织形态学结果的相关性。材料与方法：采用单体素PRESS(Point resolred spectroscopy)序列对15只不同月龄(4～13月，平均8.6±3.2月)健康新西兰雌性白兔行L7椎体MRS采集。波谱分析采用SAGE 7.0波谱分析软件，计算椎体波谱的脂水比(Lipid waterratio，LWR)。MRS采集结束后取出相应扫描椎体，并制作常规HE染色切片，组织切片图像分析采用Image-pro plus 5.0软件，计算黄髓、红髓的面积比。结果：兔椎体MRS显示LWR 0.263～2.594，平均0.881±0.59；组织切片黄、红髓面积比0.114～3.45，平均1.166±0.88，两者相关系数r=0.817(P＜0.01)，直线回归方程LWR=0.24+0.55×黄红髓面积比。结论：椎体MRS同组织形态学结果存在相关性，椎体骨髓中红、黄髓组成比例的变化可以较好地被LWR予以反映，从而为椎体MRS提供了一定的组织形态学基础。
第二部分 骨质疏松及相关椎体骨折的磁共振波谱成像(MRS)评估
目的：探讨椎体~1H MRS测量值同DXA、QCT所测骨密度的相关性及其对骨质疏松及相关椎体骨折的评估价值。材料与方法：共有152例(30～80岁，平均58.2±14.2岁)女性志愿者分别进行以下检查：胸腰椎侧位(T4-L4)平片，并采用Genant半定量法对其进行评阅。腰椎及股骨近端双能X线(DXA)骨密度测量。腰椎定量CT(QCT)骨密度测量。腰椎常规矢状位T_2WI、T_1WI和横轴位T_2WI扫描。
Part one: Pilot study of vertebral bone marrow by MR
Spectroscopy in rabbits
Objective: The aim of the study was to evaluate the relationship between vertebral magnetic resonance spectroscopy (MRS) and histomorphology in rabbits. Materials and methods: A total of fifteen healthy Zelanian rabbits (mean age 8.6 ± 3.2 months, range 4~13months) underwent single voxel (SV) ~1H MRS examination at the lumbar spine (L7) with point resolved spectroscopy (PRESS) sequence. Lipid water ratio (LWR) was measured by SAGE 7.0 software. The vertebral body was dissected after MRS examination. Then the histomorphological slices were stained with H.E method. The Image-pro plus 5.0 software was used to analyze the histomorphological slices and to calculate the ratio of yellow bone marrow area to red bone marrow area in vertebral body. Results: Mean value of LWR of the vertebral body was 0.881±0.59 (range 0.263~2.594). The mean yellow/red bone marrow ratio from histomorphological slices was 1.166±0.88 (range 0.114~ 3.457). A positive correlation was found between LWR and area ratio (r=0.817,P<0.01). The linear regression equation from the correlation was obtained (LWR=0.24+0.55 × area ratio). Conclusion: LWR could partially reflect the yellow/red bone marrow ratio in vertebral body. The changes of vertebral bone marrow could provide a histomorphological basis for the vertebral MRS.
Part two: Potential value of vertebral proton MR Spectroscopy
in determining osteoporosis and vertebral fracture
Objective: To investigate the correlation between vertebral proton
引文
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