穴位埋线治疗单纯性肥胖病的临床评价及实验研究
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摘要
针灸治疗单纯性肥胖病具有减肥作用明显、疗效持久,很少反弹,无毒副作用、简便价廉等特点,深受广大肥胖患者的欢迎。近年来,针灸治疗肥胖病研究在临床及实验方面取得较大进展。本课题采用穴位埋线疗法,其使用器械简单,操作简便,几无疼痛,且疗效持久,病人易于接受的穴位埋线减肥疗法。
研究目的:探讨穴位埋线法治疗肥胖的疗效,进一步明确穴位埋线法减肥的作用机制。
研究方法:本研究从文献回顾、临床研究及实验研究三个方面进行。
文献研究:系统回顾了肥胖病的流行病学、发病机制及病理改变、中医对肥胖症病因病机的认识、中医治疗肥胖症的治则、针灸治疗肥胖症的临床及实验研究。文献研究结果表明肥胖症是由遗传因素、环境因素及某些特定的生化因子引起的一种慢性进食调控及代谢紊乱的疾病,发病较复杂,确切的机制还不明确。目前药物疗法的靶位是能量的摄入,能量的消耗或是其它能量储存系统,主要有以下几类:食欲抑制剂、代谢促进剂、消化吸收阻碍剂、胰岛素增敏剂、降低血脂药物等。但其使用范围存在一定限制且有较多副作用。中医治疗肥胖的研究领域中,针灸治疗具有独特优势,体针、耳针、穴位埋线治疗在临床应用广泛,并认为其针灸作用机理主要通过实现对神经、内分泌系统的调节而控制食欲,降低血脂。
临床研究:本组病例共60例,均来自广州中医药大学第一附属医院2008年8月～2009年5月针灸减肥门诊就诊的腹型肥胖患者,参照1997年全国第5届肥胖病研究学术会议修订的《单纯性肥胖病的诊断及疗效评定标准》,经临床检查确诊为单纯性肥胖病者。临床研究以单纯性肥胖症患者为观察对象,选取中脘、水分、气海、关元、天枢、大横等穴进行穴位埋线。观察穴位埋线治疗肥胖的临床疗效及对各项肥胖指标(包括体重、肥胖度、体重指数)、三围(胸围、腰围、臀围)、血脂、血糖的影响,探讨穴位埋线法治疗肥胖的作用机理。
动物实验研究:将肥胖大鼠单笼饲养,并随机分为模型对照组、药物治疗组、穴位埋线组,治疗前使其适应环境一周。其中药物治疗组穴位埋线组每天分别给予相应时间的相应治疗,模型对照组不做任何治疗。局部消毒后将针刺入大鼠“后三里”、中脘,根据相应穴位肌肉丰度将适当长度的羊肠线推入组织中。实验研究通过观察穴位埋线对肥胖大鼠的治疗作用,探讨其减肥疗效。并采用体重、体长、Lee's指数、肾周脂肪细胞湿重、以及胆固醇、甘油三脂等指标以综合考察这种治疗方法的治疗效果。
结果:
临床研究:埋线治疗组与治疗前比较体重改善差异有显著性(p＜0.01),赛尼可组治疗前后体重变化差异无显著性(p＞0.05),两组治疗后比较差异有显著性(p＜0.01)。两组在治疗前空腹血糖(FPG)、空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)无显著性差异(P＞0.05),埋线治疗组和药物治疗组治疗前后FINS、HOMA-IR差别有统计学意义(P＜0.05),且治疗组对HOMA-IR的影响与对照组的差异有统计学意义P＜0.05。两组在治疗前胆固醇(CHOL)、甘油三脂(TG)、高密度脂蛋白胆固醇(HDL-c)、低密度脂蛋白胆固醇(LDL-c)均无显著性差异(P＞0.05),且均值在正常范围内,靠近上限。穴位埋线治疗组和对照组在治疗前后CHOL、TG均有回降,差异有统计学意义(P＜0.05),HDL回升,差异有统计学意义(P＜0.05);疗程结束8周后,继续观察患者各项相关指标,两组体重疗效比较,药物对照组30例,显效2(6.6%),有效6(20%),无效22(76.7%),总有效率8(26.7%),而穴位埋线治疗组30例,显效7(23.3%),有效18(60%),无效5(16.7%),总有效率25(83.3%)。两组血脂比较,药物对照组30例,显效7(23.3%),有效9(30%),无效14(46.7%),总有效率16(53.3%),而穴位埋线治疗组30例,显效12(40%),有效11(36.7%),无效7(23.3%),总有效率23(76.7%)。由此可见在临床治疗单纯性肥胖中埋线治疗组明显优于药物对照组。综合文献及临床研究结果表明该疗法具有简便易行、病人痛苦小,疗效肯定、作用持久、无副作用、安全可靠的特点,特别是该疗法只需一周一次,减少了就诊次数,节约了病人就诊时间,深受广大患者欢迎。
动物实验研究:经过高脂饲养,治疗前各组和模型组相比体重明显增加,治疗2周后,穴位埋线组大鼠体重与模型组对比增加相对缓慢,但没有明显差异。治疗4周后穴位埋线组及口服药物组大鼠与模型组相比体重差异明显。穴位埋线治疗组Lee's指数与模型组相比显著降低,且差异具有显著性(P＜0.01)。经过不同方法治疗脂肪湿重及血清MDA的含量,药物治疗组与模型对照组比较差异有显著性(P＜0.05);埋线治疗组与模型组比较有显著性差异(P＜0.01)。穴位埋线组及口服药物组与模型组相比血清甘油三脂水平明显降低,而总胆固醇水平变化不明显。药物治疗组与模型对照组下丘脑一氧化氮(NO)比较差异有显著性(P＜0.05);而穴位埋线治疗组下丘脑一氧化氮合酶(NOS)、血清丙二醛(MDA)与口服药物组比较有显著性差异(P＜0.01)。综合文献及实验研究,表明穴位埋线法对治疗肥胖病的机制可能是从神经、内分泌等角度调节大鼠摄食、饮水等行为活动,达到减肥的效果;而穴位埋线疗法似乎比药物治疗组效果更加明显;结果表明穴位埋线法是一种融多种疗法(针刺、类似埋针、持久行针等)、多种效应于一体的复合性治疗方法,其机理为多种刺激同时发挥作用。本研究结果为进一步阐明针灸治疗肥胖的发病机理和临床研究提供实验基础和理论依据。
结论:
(1)口服赛尼可治疗组和穴位埋线疗法都可以降低单纯性肥胖患者的体重、体重指数(BMI),减小腰围,因此两种疗法对单纯性肥胖都有较好的治疗作用;其中在减小腰围方面,穴位埋线优于口服赛尼可治疗组(P＜0.01)。
(2)通过临床观察和动物实验证实,穴位埋线可以降低空腹胰岛素水平,改善胰岛素抵抗状态,可有效预防糖、脂代谢的发生,并且穴位埋线优于口服赛尼可治疗组(P＜0.01)。
(3)通过临床观察和动物实验证实,穴位埋线可以调节脂代谢,使胆固醇(CHOL)、甘油三脂(TG)回降、高密度脂蛋白胆固醇(HDL-c)升高。
(4)通过临床观察和动物实验证实与赛尼可组相比较,穴位埋线组更安全、有效、毒副作用少。更进一步的推进了穴位埋线的推广及应用。
(5)通过临床观察和动物实验证实,穴位埋线组的远期疗效明显优于赛尼可组,经穴位埋线组治疗后患者疗效持久。从本课题研究中我们可以看出穴位埋线法治病的功效具有延续性,在治疗停止之后,治疗作用依旧在延续。
Acupuncture treatment for Obesity is very effective and long lasting with less side-effect method to loss weight,it is inexpensive and acceptable.In recent years,acupuncture obesity in clinicaland laboratory research has made great progress.This study is used the traditional method of catgut implantation treatment,to seeking a long term method to have a lasting effects, simple to operate,and less pain method to treat obesity.
Objective:To explore the effective acupoint by using catgut embedding treatment for weight loss,and further embedding method points clear mechanism of weight loss,this study is in the tree areas of a literature review,clinical research and experimental study.
Methods:the literature has Systematical reviewed of obesity in epidemiology, pathogenesis and pathological changes;it also included the pathogenesis of the traditional Chinese medical ways of treating obesity.From the Clinical and Experimental Research is to come up the rule of the best acupuncture treatment for obesity.All the literature results show that obesity has the common factors of genetic,environmental and certain biochemical caused by a chronic eating disorders and metabolic control of the disease,the incidence of more complicated,the exact mechanism is unclear.In the present,drug therapy is focus on the target of energy intake,energy consumption or other energy storage systems,mainly in the following categories:loss of appetite inhibitors;metabolism enhancers;hinder digestion and absorption agent; insulin sensitizer;lowering drugs such as lipid.But there are certain restrictions on the use and have more side effects.Chinese medicine treatment of obesity research has a unique advantage by using the acupuncture method such as body acupuncture,ear acupuncture,catgut embedding therapy in clinical of wide range.The applications treatment and its mechanism of acupuncture is mainly through the realization of a neural regulation of the endocrine system to control appetite,reduce the lipids.
Clinical research:The case of a total of 60 cases,all the data is collected from the Guangzhou University of Traditional Chinese Medicine First Affiliated Hospital in August 2008 to May 2009.The weight patients come to the clinics for weight loss with abdominal obesity will included in this study.The 5~(th) national Obesity Research Academic Council amended the "simple obesity and effects of diagnostic criteria" in 1997,it has confirmed by clinical examination for patients with simple obesity.Clinical studies is based on the observation of the obesity,it observed the effectiveness of using differentiation method of selected points and catgut embedding therapy.The evalution is base on the various indicators,such as(body weight,obesity degree,body mass index),measurements,blood lipids,blood glucose.The end result is to explore its mechanism.
laboratory Study:It was randomly divided the obese rats into model control group,medication group,catgut embedding group put into the single-cage rearing to feed for a a week to adapt to the environment before the treatment. Both catgut embedding and drug treatment group were given a corresponding groups their treatment each day,but the control group gave no treatment at all.The catgut embedding group was implanted the catgut into acupuncture points zu san li、zhong wan after the sterilization.The length of the catgut is used by according to the appropriate deep of the acupuncture point of the tissue,and followed by setting a plaster after finished.In the process will Check the plaster every 3 days,if laid off then implanted the catgut back on and cover with plaster again.The catgut implant was done every Monday morning,and observed for 4 weeks.The medicinal group was using 35mg/kg of Xenical(Orlistat) by oral gavage administration,it also observed for 4 weeks.The laboratory study is observed the effect of rats weight by implanted through the catgut embedding method.The Lee's index was used as this study treatment effectiveness.It included the perirenal fat cells wet weight,as well as cholesterol,triglycerides as the indicators.
Results:Clinical research:catgut embedding group compared the body weight differences with pre-treatment have significantly improve(p＜0.01),Xenical weight changed before and after treatment there was no significant difference (p＞0.05),compared the two groups after treatment there was a significant difference(p＜0.01).The two groups in the pre-treatment FPG,FINS,HOMA-IR was no significant difference(P＞0.05),catgut embedding group and medication group compared on FINS,HOMA-IR were statistically significant differences(P＜0.05).The treatment group on the impact of HOMA-IR with the control group were statistically significant differences(P＜0.05).The two groups' CHOL,TG,HDL,LDL were not significantly different before treatment(P＞0.05),and also in the normal range.Catgut embedding group and control groups' CHOL,TG before and after the treatment were lower,has the significant difference(P＜0.05),HDL rose,the difference was statistically significant(P＜0.05).Medicinal group in 30 cases were cured of 4(13.3%), effective rate of 21(70%),Invalid of 5(16.7%),the total effective rate of 83.3%.The Catgut embedding group in 30 cases were cured of 7(23.3%), effective rate of 22(73.4%),Invalid of 1(3.3%),total effective rate of 96.7%. In this study,the result of the Catgut embedding group was significantly better than the medication group.Comprehensive documentation of the statistic the catgut embedding group show this therapy has a simple way,less pain.The finding was positive effect,lasting,with no side effects,safety and reliability.In particular,the patients come only to the clinic for this therapy once a week and also reduce the number of visits,it is time-saving treatment of patients.Therefore,the majority of patients were more acceptable.
Laboratory Study:rats' body weight had remarkable increased after being feeding the high-fat food.After two weeks treatments,the weight of the Catgut embedding group had almost no increased,but there is no significant difference between groups.The weight of the two treatment groups of the rats had significantly differences after 4 weeks.According to Lee's index,the catgut embedding group had significantly weight loss of(P＜0.01) after 4 weeks. After the treatment of different methods of fat wet weight and serum MDA content, medication group compared with the control group has P＜0.05;Catgut embedding group compared with the control group has P＜0.01.There was a significant difference.After different treatments,the total cholesterol and triglyceride levels and body weight of the control group compared to the treatment group had significantly increased.The two treatment groups had compared to the control group after 4 weeks.The rats' total cholesterol levels had no significant changes.But the triglyceride had reduced significantly.The medication group and control group has difference of P＜0.05.Catgut embedding group had compared to the control group on NPY, NO,NOS with significantly difference of(P＜0.01).From the literature, laboratory and the clinical study showed the catgut embedding treatment for obesity to loss weight has its mechanism for nerves system to control the endocrine regulation of food and water intake.The catgut embedding group was more effective than the medication group.For the result,it showed catgut embedding treatment was embedding into avariety acupuncture therapies,such as acupuncture,needles buried,and electrical needling.It has a wide range of stimulating role at the same time.The results of this study acupuncture in order to further clarify the pathogenesis of obesity and clinical research to provide an experimental basis and theoretical basis.
Conclusion:
1.Xenical treatment group and catgut embedding treatment group can reduce obesity patients' the body weight,BMI,waist decrease,Therefore,the two groups have a good therapeutic effect;which reduce the waistline,the catgut embedding group is better than embedding Xenical group(P＜0.01)。
2.Through clinical observation and laboratory study confirm that Catgut embedding can lower levels of fasting insulin and improve insulin resistance may be effective in preventing glucose and lipid metabolism,and Catgut embedding is better than Xenical group(P＜0.01)。
3.Through clinical observation and laboratory study confirm that the acupuncture points can regulate lipid metabolism embedding,so as CHOL,TG go back down,and HDL increased.
4.Through clinical observation and laboratory study confirm that catgut embedding compared to Xenical group is more secure,effective and less toxic with less side effects.Further advance to be promoted and applicable.
5.Through clinical observation and animal experiments confirm that catgut embedding group was superior to the long-term effect of Xenical group.Catgut embedding group has long lasting effects after treatment.The effectiveness of the catgut embedding has the ability to continuity of the disease,after cessation of treatment.
研究目的:探讨穴位埋线法治疗肥胖的疗效,进一步明确穴位埋线法减肥的作用机制。
研究方法:本研究从文献回顾、临床研究及实验研究三个方面进行。
文献研究:系统回顾了肥胖病的流行病学、发病机制及病理改变、中医对肥胖症病因病机的认识、中医治疗肥胖症的治则、针灸治疗肥胖症的临床及实验研究。文献研究结果表明肥胖症是由遗传因素、环境因素及某些特定的生化因子引起的一种慢性进食调控及代谢紊乱的疾病,发病较复杂,确切的机制还不明确。目前药物疗法的靶位是能量的摄入,能量的消耗或是其它能量储存系统,主要有以下几类:食欲抑制剂、代谢促进剂、消化吸收阻碍剂、胰岛素增敏剂、降低血脂药物等。但其使用范围存在一定限制且有较多副作用。中医治疗肥胖的研究领域中,针灸治疗具有独特优势,体针、耳针、穴位埋线治疗在临床应用广泛,并认为其针灸作用机理主要通过实现对神经、内分泌系统的调节而控制食欲,降低血脂。
临床研究:本组病例共60例,均来自广州中医药大学第一附属医院2008年8月～2009年5月针灸减肥门诊就诊的腹型肥胖患者,参照1997年全国第5届肥胖病研究学术会议修订的《单纯性肥胖病的诊断及疗效评定标准》,经临床检查确诊为单纯性肥胖病者。临床研究以单纯性肥胖症患者为观察对象,选取中脘、水分、气海、关元、天枢、大横等穴进行穴位埋线。观察穴位埋线治疗肥胖的临床疗效及对各项肥胖指标(包括体重、肥胖度、体重指数)、三围(胸围、腰围、臀围)、血脂、血糖的影响,探讨穴位埋线法治疗肥胖的作用机理。
动物实验研究:将肥胖大鼠单笼饲养,并随机分为模型对照组、药物治疗组、穴位埋线组,治疗前使其适应环境一周。其中药物治疗组穴位埋线组每天分别给予相应时间的相应治疗,模型对照组不做任何治疗。局部消毒后将针刺入大鼠“后三里”、中脘,根据相应穴位肌肉丰度将适当长度的羊肠线推入组织中。实验研究通过观察穴位埋线对肥胖大鼠的治疗作用,探讨其减肥疗效。并采用体重、体长、Lee's指数、肾周脂肪细胞湿重、以及胆固醇、甘油三脂等指标以综合考察这种治疗方法的治疗效果。
结果:
临床研究:埋线治疗组与治疗前比较体重改善差异有显著性(p＜0.01),赛尼可组治疗前后体重变化差异无显著性(p＞0.05),两组治疗后比较差异有显著性(p＜0.01)。两组在治疗前空腹血糖(FPG)、空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)无显著性差异(P＞0.05),埋线治疗组和药物治疗组治疗前后FINS、HOMA-IR差别有统计学意义(P＜0.05),且治疗组对HOMA-IR的影响与对照组的差异有统计学意义P＜0.05。两组在治疗前胆固醇(CHOL)、甘油三脂(TG)、高密度脂蛋白胆固醇(HDL-c)、低密度脂蛋白胆固醇(LDL-c)均无显著性差异(P＞0.05),且均值在正常范围内,靠近上限。穴位埋线治疗组和对照组在治疗前后CHOL、TG均有回降,差异有统计学意义(P＜0.05),HDL回升,差异有统计学意义(P＜0.05);疗程结束8周后,继续观察患者各项相关指标,两组体重疗效比较,药物对照组30例,显效2(6.6%),有效6(20%),无效22(76.7%),总有效率8(26.7%),而穴位埋线治疗组30例,显效7(23.3%),有效18(60%),无效5(16.7%),总有效率25(83.3%)。两组血脂比较,药物对照组30例,显效7(23.3%),有效9(30%),无效14(46.7%),总有效率16(53.3%),而穴位埋线治疗组30例,显效12(40%),有效11(36.7%),无效7(23.3%),总有效率23(76.7%)。由此可见在临床治疗单纯性肥胖中埋线治疗组明显优于药物对照组。综合文献及临床研究结果表明该疗法具有简便易行、病人痛苦小,疗效肯定、作用持久、无副作用、安全可靠的特点,特别是该疗法只需一周一次,减少了就诊次数,节约了病人就诊时间,深受广大患者欢迎。
动物实验研究:经过高脂饲养,治疗前各组和模型组相比体重明显增加,治疗2周后,穴位埋线组大鼠体重与模型组对比增加相对缓慢,但没有明显差异。治疗4周后穴位埋线组及口服药物组大鼠与模型组相比体重差异明显。穴位埋线治疗组Lee's指数与模型组相比显著降低,且差异具有显著性(P＜0.01)。经过不同方法治疗脂肪湿重及血清MDA的含量,药物治疗组与模型对照组比较差异有显著性(P＜0.05);埋线治疗组与模型组比较有显著性差异(P＜0.01)。穴位埋线组及口服药物组与模型组相比血清甘油三脂水平明显降低,而总胆固醇水平变化不明显。药物治疗组与模型对照组下丘脑一氧化氮(NO)比较差异有显著性(P＜0.05);而穴位埋线治疗组下丘脑一氧化氮合酶(NOS)、血清丙二醛(MDA)与口服药物组比较有显著性差异(P＜0.01)。综合文献及实验研究,表明穴位埋线法对治疗肥胖病的机制可能是从神经、内分泌等角度调节大鼠摄食、饮水等行为活动,达到减肥的效果;而穴位埋线疗法似乎比药物治疗组效果更加明显;结果表明穴位埋线法是一种融多种疗法(针刺、类似埋针、持久行针等)、多种效应于一体的复合性治疗方法,其机理为多种刺激同时发挥作用。本研究结果为进一步阐明针灸治疗肥胖的发病机理和临床研究提供实验基础和理论依据。
结论:
(1)口服赛尼可治疗组和穴位埋线疗法都可以降低单纯性肥胖患者的体重、体重指数(BMI),减小腰围,因此两种疗法对单纯性肥胖都有较好的治疗作用;其中在减小腰围方面,穴位埋线优于口服赛尼可治疗组(P＜0.01)。
(2)通过临床观察和动物实验证实,穴位埋线可以降低空腹胰岛素水平,改善胰岛素抵抗状态,可有效预防糖、脂代谢的发生,并且穴位埋线优于口服赛尼可治疗组(P＜0.01)。
(3)通过临床观察和动物实验证实,穴位埋线可以调节脂代谢,使胆固醇(CHOL)、甘油三脂(TG)回降、高密度脂蛋白胆固醇(HDL-c)升高。
(4)通过临床观察和动物实验证实与赛尼可组相比较,穴位埋线组更安全、有效、毒副作用少。更进一步的推进了穴位埋线的推广及应用。
(5)通过临床观察和动物实验证实,穴位埋线组的远期疗效明显优于赛尼可组,经穴位埋线组治疗后患者疗效持久。从本课题研究中我们可以看出穴位埋线法治病的功效具有延续性,在治疗停止之后,治疗作用依旧在延续。
Acupuncture treatment for Obesity is very effective and long lasting with less side-effect method to loss weight,it is inexpensive and acceptable.In recent years,acupuncture obesity in clinicaland laboratory research has made great progress.This study is used the traditional method of catgut implantation treatment,to seeking a long term method to have a lasting effects, simple to operate,and less pain method to treat obesity.
Objective:To explore the effective acupoint by using catgut embedding treatment for weight loss,and further embedding method points clear mechanism of weight loss,this study is in the tree areas of a literature review,clinical research and experimental study.
Methods:the literature has Systematical reviewed of obesity in epidemiology, pathogenesis and pathological changes;it also included the pathogenesis of the traditional Chinese medical ways of treating obesity.From the Clinical and Experimental Research is to come up the rule of the best acupuncture treatment for obesity.All the literature results show that obesity has the common factors of genetic,environmental and certain biochemical caused by a chronic eating disorders and metabolic control of the disease,the incidence of more complicated,the exact mechanism is unclear.In the present,drug therapy is focus on the target of energy intake,energy consumption or other energy storage systems,mainly in the following categories:loss of appetite inhibitors;metabolism enhancers;hinder digestion and absorption agent; insulin sensitizer;lowering drugs such as lipid.But there are certain restrictions on the use and have more side effects.Chinese medicine treatment of obesity research has a unique advantage by using the acupuncture method such as body acupuncture,ear acupuncture,catgut embedding therapy in clinical of wide range.The applications treatment and its mechanism of acupuncture is mainly through the realization of a neural regulation of the endocrine system to control appetite,reduce the lipids.
Clinical research:The case of a total of 60 cases,all the data is collected from the Guangzhou University of Traditional Chinese Medicine First Affiliated Hospital in August 2008 to May 2009.The weight patients come to the clinics for weight loss with abdominal obesity will included in this study.The 5~(th) national Obesity Research Academic Council amended the "simple obesity and effects of diagnostic criteria" in 1997,it has confirmed by clinical examination for patients with simple obesity.Clinical studies is based on the observation of the obesity,it observed the effectiveness of using differentiation method of selected points and catgut embedding therapy.The evalution is base on the various indicators,such as(body weight,obesity degree,body mass index),measurements,blood lipids,blood glucose.The end result is to explore its mechanism.
laboratory Study:It was randomly divided the obese rats into model control group,medication group,catgut embedding group put into the single-cage rearing to feed for a a week to adapt to the environment before the treatment. Both catgut embedding and drug treatment group were given a corresponding groups their treatment each day,but the control group gave no treatment at all.The catgut embedding group was implanted the catgut into acupuncture points zu san li、zhong wan after the sterilization.The length of the catgut is used by according to the appropriate deep of the acupuncture point of the tissue,and followed by setting a plaster after finished.In the process will Check the plaster every 3 days,if laid off then implanted the catgut back on and cover with plaster again.The catgut implant was done every Monday morning,and observed for 4 weeks.The medicinal group was using 35mg/kg of Xenical(Orlistat) by oral gavage administration,it also observed for 4 weeks.The laboratory study is observed the effect of rats weight by implanted through the catgut embedding method.The Lee's index was used as this study treatment effectiveness.It included the perirenal fat cells wet weight,as well as cholesterol,triglycerides as the indicators.
Results:Clinical research:catgut embedding group compared the body weight differences with pre-treatment have significantly improve(p＜0.01),Xenical weight changed before and after treatment there was no significant difference (p＞0.05),compared the two groups after treatment there was a significant difference(p＜0.01).The two groups in the pre-treatment FPG,FINS,HOMA-IR was no significant difference(P＞0.05),catgut embedding group and medication group compared on FINS,HOMA-IR were statistically significant differences(P＜0.05).The treatment group on the impact of HOMA-IR with the control group were statistically significant differences(P＜0.05).The two groups' CHOL,TG,HDL,LDL were not significantly different before treatment(P＞0.05),and also in the normal range.Catgut embedding group and control groups' CHOL,TG before and after the treatment were lower,has the significant difference(P＜0.05),HDL rose,the difference was statistically significant(P＜0.05).Medicinal group in 30 cases were cured of 4(13.3%), effective rate of 21(70%),Invalid of 5(16.7%),the total effective rate of 83.3%.The Catgut embedding group in 30 cases were cured of 7(23.3%), effective rate of 22(73.4%),Invalid of 1(3.3%),total effective rate of 96.7%. In this study,the result of the Catgut embedding group was significantly better than the medication group.Comprehensive documentation of the statistic the catgut embedding group show this therapy has a simple way,less pain.The finding was positive effect,lasting,with no side effects,safety and reliability.In particular,the patients come only to the clinic for this therapy once a week and also reduce the number of visits,it is time-saving treatment of patients.Therefore,the majority of patients were more acceptable.
Laboratory Study:rats' body weight had remarkable increased after being feeding the high-fat food.After two weeks treatments,the weight of the Catgut embedding group had almost no increased,but there is no significant difference between groups.The weight of the two treatment groups of the rats had significantly differences after 4 weeks.According to Lee's index,the catgut embedding group had significantly weight loss of(P＜0.01) after 4 weeks. After the treatment of different methods of fat wet weight and serum MDA content, medication group compared with the control group has P＜0.05;Catgut embedding group compared with the control group has P＜0.01.There was a significant difference.After different treatments,the total cholesterol and triglyceride levels and body weight of the control group compared to the treatment group had significantly increased.The two treatment groups had compared to the control group after 4 weeks.The rats' total cholesterol levels had no significant changes.But the triglyceride had reduced significantly.The medication group and control group has difference of P＜0.05.Catgut embedding group had compared to the control group on NPY, NO,NOS with significantly difference of(P＜0.01).From the literature, laboratory and the clinical study showed the catgut embedding treatment for obesity to loss weight has its mechanism for nerves system to control the endocrine regulation of food and water intake.The catgut embedding group was more effective than the medication group.For the result,it showed catgut embedding treatment was embedding into avariety acupuncture therapies,such as acupuncture,needles buried,and electrical needling.It has a wide range of stimulating role at the same time.The results of this study acupuncture in order to further clarify the pathogenesis of obesity and clinical research to provide an experimental basis and theoretical basis.
Conclusion:
1.Xenical treatment group and catgut embedding treatment group can reduce obesity patients' the body weight,BMI,waist decrease,Therefore,the two groups have a good therapeutic effect;which reduce the waistline,the catgut embedding group is better than embedding Xenical group(P＜0.01)。
2.Through clinical observation and laboratory study confirm that Catgut embedding can lower levels of fasting insulin and improve insulin resistance may be effective in preventing glucose and lipid metabolism,and Catgut embedding is better than Xenical group(P＜0.01)。
3.Through clinical observation and laboratory study confirm that the acupuncture points can regulate lipid metabolism embedding,so as CHOL,TG go back down,and HDL increased.
4.Through clinical observation and laboratory study confirm that catgut embedding compared to Xenical group is more secure,effective and less toxic with less side effects.Further advance to be promoted and applicable.
5.Through clinical observation and animal experiments confirm that catgut embedding group was superior to the long-term effect of Xenical group.Catgut embedding group has long lasting effects after treatment.The effectiveness of the catgut embedding has the ability to continuity of the disease,after cessation of treatment.
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