依托咪酯-丙泊酚混合液复合瑞芬太尼在无痛人流术中的应用

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• 英文论文题名：Application of Etomidate-Propofol mixture Combined with Remifentanil in Painless Abortion
• 论文作者：黎荣福 ; 费宏亮 ; 裕红 ; 刘冬娜
• 英文论文作者：LI Rong-fu ; FEI Hong-liang ; YU Hong ; LIU Dong-na ; Department of Anesthesiology ; Beijing Yanhua Hospital
• 年：2017
• 作者机构：北京燕化医院麻醉科;
• 论文关键词：依托咪酯 ; 丙泊酚 ; 瑞芬太尼 ; 人工流产术
• 英文论文关键词：etomidate ; propofol ; remifentanil ; artificial abortion
• 会议召开时间：2017-05-26
• 会议录名称：2017年《中国组织化学与细胞化学杂志》临床研讨会论文集
• 语种：中文
• 分类号：R169.42
• 学会代码：ZHXB
• 会议名称：2017年《中国组织化学与细胞化学杂志》临床研讨会
• 会议地点：中国湖北武汉
• 主办单位：《中国组织化学与细胞化学杂志》社有限公司
• 学会名称：《中国组织化学与细胞化学杂志》社有限公司
• 页数：2
• 文件大小：255k
• 原文格式：O
• 会议级别：全国

摘要

目的:观察依托咪酯-丙泊酚混合液(2mg:10mg)复合瑞芬太尼用于无痛人流术的安全性。方法:将200例行人流术的患者随机分为2组,每组100例。所有病例均提前30秒缓慢静脉注射瑞芬太尼1μg/kg,随后Ⅰ组注射丙泊酚0.15ml/kg,Ⅱ组注射依托咪酯-丙泊酚混合液0.15ml/kg。术中视患者肢体反应情况,Ⅰ组追加丙泊酚,Ⅱ组追加混合液,每次3~5ml。记录2组患者不同时点的生命体征、苏醒时间及不良反应。结果:术中Ⅰ组比Ⅱ组呼吸循环抑制明显(P<0.05);Ⅱ组的苏醒时间短于Ⅰ组(P<0.05);两组不良反应相当(P>0.05)。结论:复合瑞芬太尼用于无痛人流手术,依托咪酯-丙泊酚混合液较单纯丙泊酚麻醉的呼吸循环更稳定,苏醒更快,提高了患者的安全性。
Objective:To investigate the safety of etomidate-propofol(2mg:10mg) mixture in painless abortion combined with remifentanil.Methods:200 pregnant women who selected painless artificial abortion were randomly divided into two groups,each 100.All were given with remifentanil lμg/kg 30 seconds in advance,then group Ⅰ was injected intravenously with propofol 0.15ml/kg and group Ⅱ was injected with etomidate-propofol mixture 0.15ml/kg.The drug respective was added 3~5ml each time in accordance with the dynamic response.The Vital signs at different time points,wake-up time and adverse reactions were recorded.Results:The inhibition of breathing and circulation in patients of group Ⅰ was significant than that of patients in group Ⅱ(P < 0.05),the wake-up time was shorter in group Ⅱ compared with group Ⅰ(P <0.05),the difference in adverse reactions in two groups was not significant(P >0.05).Conclusions;Combined with remifentanil in painless abortion,the hemodynamics and respiration of etomidate-propofol mixture was more stable than only using propofol.It can shorten the wake-up time,and improve the patient s safety.

引文

[1]叶惠珍,博志海,吴雅松,等.深呼吸预防无痛人流术中呼吸抑制的效果[J].南昌大学学报(医学版),2013,53(4):79-80.
    [2]贾瑞芳,付艳芳,孟晓燕,等.丙泊酚分别伍用瑞芬太尼与芬太尼在无痛人工流产术中的应用比较[J].医药导报,2010,29(3):313-316.
    [3]Saricaoglu F,Uzun S,Arun O,et al.A clinical comparison of etomidate-lipuro,propofol and admixture at induction[J].Saudi J Anaesth,2011,5(1):62-66.
    [4]刘荣芳,周华成,刘金峰.预防依托咪酯诱发肌颤的研究进展[J].临床麻醉学杂志,2014,30(2):198-200.
    [5]Ko BJ,Oh JN,Lee JH,et al.Comparison of effects of fentanyl and remifentanil on hemodynamic response to endotracheal intubation and myoclonus in elderly patients with etomidate induction[J].Korean J anesthesiol,2013,64(1):12-18.
    [6]胡雅芳,凌美霞.丙泊酚减少无痛人工流产术中依托咪酯脂肪乳剂致肌震颤的效果观察[J].现代实用医学,2014,26(2):137-138.
    [7]Kim E,Kim C H,Kim H K,et al.Effect of nitrous oxide inhalation on pain after propofol and rocuronium injection[J].J Anesth,2013,27(6):868-873.
    [8]Kim K,Sung-Kim Y,Lee D K,et al.Reducing the pain of microemulsion propofol injections:a double-blind,randomized study of three methods:of tourniquet and lidocaine[J].Clin Ther,2013,35(11);1734-1743.
    [9]Myklejord DJ,Yao L,Liang H,et al.Consensus guideline adoption for managing postoperative nausea and vomiting[J].WMJ,2012,111(5);207-213.