黄芪多糖的药理作用研究
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摘要
黄芪多糖作为中药黄芪的主要活性成分,关于其药理作用的研究多涉及循环系统、神经系统、消化系统、免疫系统、内分泌系统、造血系统,对近年来黄芪多糖在抗动脉粥样硬化,保护视网膜,改善记忆力、认知功能、抗衰老、抗骨质疏松及防治帕金森病等方面的药理作用进行归纳,为今后研究提供参考。
Astragalus polysaccharides is the main active ingredient of Huangqi(astragali radix), the studies on its pharmacological action involve circulatory system, nervous system, digestive system, immune system, endocrine system and hematopoietic system. The paper is mainly reviewing its pharmacological actions including anti-atherosclerosis, protecting retina, improving memory, cognitive function, anti-aging, anti-osteoporosis, preventing and treating Parkinson′s disease in the recent years, to provide the reference for future study.
Astragalus polysaccharides is the main active ingredient of Huangqi(astragali radix), the studies on its pharmacological action involve circulatory system, nervous system, digestive system, immune system, endocrine system and hematopoietic system. The paper is mainly reviewing its pharmacological actions including anti-atherosclerosis, protecting retina, improving memory, cognitive function, anti-aging, anti-osteoporosis, preventing and treating Parkinson′s disease in the recent years, to provide the reference for future study.
引文
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[5]张竞之,陈利国,胡小勤,等.黄芪多糖对高血压病患者血清致伤血管内皮细胞TLR4、NF-kB表达的影响[J].山东大学学报(医学版),2010,48(12):120-123.
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[10]陈蕊,高颖.黄芪多糖对THP-1源性巨噬细胞TLR4、Syk、Erk及Paxillin蛋白磷酸化水平与细胞吞噬功能的影响[J].中华中医药杂志,2016,31(5):1679-1683.
[11]司俊康,郭俊国.黄芪多糖对过氧化氢诱导大鼠视网膜神经节细胞氧化损伤的保护作用[J].中国中医眼科杂志,2014,24(4):235-239.
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[15]Murthy RK,Ravi K,Balaiya S.Lutein protects retinal pigment epithelium from cytotoxic oxidative stress[J].Cutaneous and Ocular Toxicology,2014,33(2):132-137.
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[19]司俊康,郭俊国,郭大东,等.黄芪多糖对过氧化氢诱导人视网膜色素上皮细胞氧化损伤的保护作用[J].眼科新进展,2015,35(1):18-21.
[20]张赓,吴金娟,姜淼,等.中医药治疗阿尔茨海默病的研究进展[J].中国实验方剂学杂志,2014,20(6):217-22.
[21]应侠,吴振,雷严,等.阿尔茨海默病的发病机制及治疗药物研究进展[J].中国药房,2014,25(33):3152-3155.
[22]万鹏,王师.黄芪多糖对小鼠学习记忆能力的影响[J].延边大学医学学报,2011,34(1):23-25.
[23]费洪新,高音,孙丽慧,等.黄芪多糖对阿尔茨海默病小鼠海马组织的影响[J].中国老年学杂志,2015,35(16):4426-4429.
[24]李娜,李慧丽,刘德山.黄芪多糖对糖尿病大鼠认知功能障碍的改善作用[J].中国老年学杂志,2017,37(9):2098-2100.
[25]毕敏,尹政.核桃仁提取物抗脑衰老作用的实验研究[J].现代中药研究与实践,2006,20(3):35-37.
[26]黄昕,徐姣,马伟.中药黄芪医疗美容应用与展望[J].中国美容医学,2017,26(5):123-125.
[27]钟灵,王振富,文德鉴.黄芪多糖抗衰老作用的实验研究[J].中国应用生理学杂志,2013,29(4):350-352.
[28]张宏波,曹文波,崔文璟,等.黄芪多糖抗去势雌鼠骨质疏松的实验研究[J].玉林师范学院学报,2012,33(5):51-55.
[29]王拥军,宋莉君,孙爱贞,等.黄芪多糖的提取及对体外培养成骨细胞成骨能力的影响[J].中国中医骨伤科,1999,7(6):3-6.
[30]刘宏伟,杨式之,徐克慧,等.尼尔雌醇预防大鼠卵巢切除后骨质疏松[J].华西医科大学学报,1993,45(1):40-44.
[31]陈璐,周群.黄芪多糖对帕金森大鼠模型的治疗作用及机制探讨[J].世界科技研究与发展,2015,37(2):168-171.
[2]仝欣.黄芪主要活性成分的药理作用[J].时珍国医国药,2011,22(5):1246-1249.
[3]陈国辉,黄文凤.黄芪的化学成分及药理作用研究进展[J].中国新药杂志,2008,17(17):1482-1485.
[4]童红莉,田亚平,汪德清,等.黄芪多糖对高脂血症大鼠血脂的调节[J].中国临床康复,2006,10(11):68-70.
[5]张竞之,陈利国,胡小勤,等.黄芪多糖对高血压病患者血清致伤血管内皮细胞TLR4、NF-kB表达的影响[J].山东大学学报(医学版),2010,48(12):120-123.
[6]梁丽娟,屠鹏飞.黄芪多糖的药理作用研究进展[J].中国药房,2010,21(43):4113-4116.
[7]何小丽,顾宁.黄芪多糖抗动脉粥样硬化研究进展[J].时珍国医国药,2014,25(6):1463-1465.
[8]张敬芳,杨雪琴,张学福.黄芪多糖抗动脉粥样硬化作用及其机制的研究[J].中国动脉硬化杂志,2011,19(3):268-269.
[9]胡国晶,路娇扬,王双.Toll样受体与动脉粥样硬化易损斑块的关系[J].中国动脉硬化杂志,2012,20(5):477-480.
[10]陈蕊,高颖.黄芪多糖对THP-1源性巨噬细胞TLR4、Syk、Erk及Paxillin蛋白磷酸化水平与细胞吞噬功能的影响[J].中华中医药杂志,2016,31(5):1679-1683.
[11]司俊康,郭俊国.黄芪多糖对过氧化氢诱导大鼠视网膜神经节细胞氧化损伤的保护作用[J].中国中医眼科杂志,2014,24(4):235-239.
[12]Promsote W,Veeranan Karmegam R,Ananth S,et al.L-2-oxothiazolidine4-carboxylic acid attenuates oxidative stress and inflammation in retinal pigment epithelium[J].MolVis,2014,20(1):73-88.
[13]Khandhadia S,Lotery A.Oxidation and age-related macular degeneration:insights from molecular biology[J].Expert Rev Mol Med,2010,12(1):34-36.
[14]Xie W,Yu W,Zhao M,et al.Protective effect of paeoniflorin against oxidative stress in human retinal pigment epithelium in vitro[J].Mol Vis,2011,17(15):3512-3522.
[15]Murthy RK,Ravi K,Balaiya S.Lutein protects retinal pigment epithelium from cytotoxic oxidative stress[J].Cutaneous and Ocular Toxicology,2014,33(2):132-137.
[16]Liu JH,Chen MM,Huang JW,et al.Therapeutic effects and mechanisms of action of mannitol during H2O2induced oxidative stress in human retinal pigment epithelium cells[J].J Ocul Pharmacol Ther,2010,26(3):249-257.
[17]Giddabasappa A,Bauler MN,Barrett CM,et al.GTx-822,an ER{beta}-selective agonist,protects retinal pigment epithelium(ARPE-19)from oxidative stress by activating MAPK and PI3-K pathways[J].Invest Ophthalmol Vis Sci,2010,51(11):5934-5942.
[18]赵颖,牛膺筠,周占宇.过氧化氢诱导人视网膜色素上皮细胞衰老及其机制探讨[J].眼科新进展,2011,31(9):804-806.
[19]司俊康,郭俊国,郭大东,等.黄芪多糖对过氧化氢诱导人视网膜色素上皮细胞氧化损伤的保护作用[J].眼科新进展,2015,35(1):18-21.
[20]张赓,吴金娟,姜淼,等.中医药治疗阿尔茨海默病的研究进展[J].中国实验方剂学杂志,2014,20(6):217-22.
[21]应侠,吴振,雷严,等.阿尔茨海默病的发病机制及治疗药物研究进展[J].中国药房,2014,25(33):3152-3155.
[22]万鹏,王师.黄芪多糖对小鼠学习记忆能力的影响[J].延边大学医学学报,2011,34(1):23-25.
[23]费洪新,高音,孙丽慧,等.黄芪多糖对阿尔茨海默病小鼠海马组织的影响[J].中国老年学杂志,2015,35(16):4426-4429.
[24]李娜,李慧丽,刘德山.黄芪多糖对糖尿病大鼠认知功能障碍的改善作用[J].中国老年学杂志,2017,37(9):2098-2100.
[25]毕敏,尹政.核桃仁提取物抗脑衰老作用的实验研究[J].现代中药研究与实践,2006,20(3):35-37.
[26]黄昕,徐姣,马伟.中药黄芪医疗美容应用与展望[J].中国美容医学,2017,26(5):123-125.
[27]钟灵,王振富,文德鉴.黄芪多糖抗衰老作用的实验研究[J].中国应用生理学杂志,2013,29(4):350-352.
[28]张宏波,曹文波,崔文璟,等.黄芪多糖抗去势雌鼠骨质疏松的实验研究[J].玉林师范学院学报,2012,33(5):51-55.
[29]王拥军,宋莉君,孙爱贞,等.黄芪多糖的提取及对体外培养成骨细胞成骨能力的影响[J].中国中医骨伤科,1999,7(6):3-6.
[30]刘宏伟,杨式之,徐克慧,等.尼尔雌醇预防大鼠卵巢切除后骨质疏松[J].华西医科大学学报,1993,45(1):40-44.
[31]陈璐,周群.黄芪多糖对帕金森大鼠模型的治疗作用及机制探讨[J].世界科技研究与发展,2015,37(2):168-171.
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