掌叶半夏化学成分及药理作用研究进展
|
摘要
综述掌叶半夏化学成分及药理作用研究进展。掌叶半夏主要含有生物碱、二肽类、氨基酸、凝集素等多种化学成分,具有抗肿瘤、抗氧化、抗惊厥、抗衰老、镇静催眠、抗心律失常等药理作用。
This paper reviews the current status of research on chemical constituents of Pinellia Pedatisecta Schott and its pharmacological effects.Pinellia Pedatisecta Schott mainly contains alkaloids,dipeptides,amino acids,lectin,and other chemical components,and has antitumor,antioxidant,anticonvulsant,anti-aging,sedative,anti-arrhythmia and other pharmacological effects.
This paper reviews the current status of research on chemical constituents of Pinellia Pedatisecta Schott and its pharmacological effects.Pinellia Pedatisecta Schott mainly contains alkaloids,dipeptides,amino acids,lectin,and other chemical components,and has antitumor,antioxidant,anticonvulsant,anti-aging,sedative,anti-arrhythmia and other pharmacological effects.
引文
[1] 上海第一医学院妇产科医院基础部化学教研组.掌叶半夏治疗子宫颈癌的研究[J].上海医学,1978,1(1):13- 14.
[2] LEE J Y,PARK N H,LEE W,et al.Comprehensive chemical profiling of Pinellia species tuber and processed Pinellia tuber by gas chromatography- mass spectrometry and liquid chromatography- atmospheric pressure chemical ionization- tandem mass spectrometry[J].J Chromatogr A,2016,1471(11):164- 177.
[3] 陆丹,罗芬,池玉梅,等.高效液相色谱法同时测定中药材虎掌南星的核苷类成分[J].色谱,2011,29(1):83- 86.
[4] DU J,DING J,MU Z Q,et al.Three new alkaloids isolated from the stem tuber of Pinellia pedatisecta[J].Chin J Nat Med,2018,16(2):139- 142.
[5] 孙光星,丁声颂,钱瑶君.掌叶半夏凝集素A的分离纯化及分析[J].上海医科大学学报,1995,22(4):299- 302.
[6] LIU X,TIAN X,LIU T,et al.Disclosure of the tuberous lectin composed of homogeneous tetramers in Pinellia pedatisecda Schott [J].Appl Biochem Biotechnol,2010,162(4):1214- 1223.
[7] 满薇.天南星科植物虎掌南星的化学成分及天南星的质量控制研究[D].长春:长春中医药大学,2012.
[8] 栾阳,张慧,康廷国.掌叶半夏脂溶性成分GC- MS研究(气相色谱质谱联用仪)[J].中国实验方剂学杂志,2013,19(2):52- 54.
[9] 李桂玲,归绥琪,陈松华,等.掌叶半夏提取物的有效部位对体外培养宫颈癌细胞的促凋亡作用[J].中华中医药杂志,2008,23(5):447- 449.
[10] LI G L,JIANG W,XIA Q,et al.HPV E6 down- regulation and apoptosis induction of human cervical cancer cells by a novel lipid- soluble extract (PE)from Pinellia pedatisecta Schott in vitro[J].J Ethnopharmacol,2010,132(1):56- 64.
[11] 李桂玲,归绥琪,夏晴,等.掌叶半夏提取物的有效部位对CaSki的促凋亡作用机制研究[J].中华中医药杂志,2010,25(3):449- 452.
[12] 李桂玲,归绥琪,朱德厚,等.掌叶半夏有效提取物单独或与顺铂联合对体外培养宫颈癌HeLa细胞的作用[J].复旦学报(医学版),2007,34(6):869- 872.
[13] ZHANG M,YU Y,ZHANG H,et al.Syergistic cytotoxic effects of a combined treatment of a Pinellia pedatisecta lipid- soluble extract and cisplatin on human cervical carcinoma in vivo[J].Oncology Letters,2017,13(6):4748- 4754.
[14] ZHANG M,ZHANG H,YU Y,et al.Synergistic effects of a novel lipid- soluble extract from Pinellia pedatisecta Schott and cisplatin on human cervical carcinoma cell lines through the regulation of DNA damage response signaling pathway[J].Oncol Lett,2017,13(4):2121- 2128.
[15] 李桂玲.掌叶半夏有效提取物对宫颈癌细胞株的抑制作用及其机制研究[D].上海:复旦大学,2008:11- 29.
[16] HUANG H,ZHANG M,YAO S,et al.Immune modulation of a lipid- soluble extract of Pinellia pedatisecta Schott in the tumor microenvironment of an HPV+ tumor- burdened mouse model[J].J Ethnopharmacol,2018,225(10):103- 115.
[17] 黄海霞,张明星,张萌,等.掌叶半夏提取物对宫颈癌荷瘤小鼠脾脏免疫的作用[J].复旦学报(医学版),2016,43(5):534- 542.
[18] 牛娜.携带掌叶半夏凝集素基因的溶瘤腺病毒研究[D].杭州:浙江理工大学,2010.
[19] 李晓艳.携带掌叶半夏凝集素基因的溶瘤腺病毒在肝癌治疗中的体内外研究[D].杭州:浙江理工大学,2013.
[20] LU Q,LI N,LUO J,et al.Pinellia pedatisecta agglutinin interacts with the methylosome and induces cancer cell death[J].Oncogenesis,2012,1(10):e29.
[21] 朱铭伟,周抗美,丁声颂.掌叶半夏总蛋白对卵巢癌细胞株及人脐血造血细胞的作用[J].上海医科大学学报,1999,26(6):455- 456.
[22] 谷杭芝,郑飞云,周莉,等.掌叶半夏总蛋白诱导人卵巢癌SKOV3细胞凋亡的实验研究[J].海峡药学,2009,21(9):160- 162.
[23] 陈小燕,周莉,郑飞云,等.掌叶半夏总蛋白作用人卵巢癌SKOV3细胞的蛋白质组学研究[J].中国中西医结合杂志,2011,31(12):1651- 1656.
[24] ZHOU L,XU T,ZHANG Y,et al.Transcriptional network in ovarian cancer cell line SKOV3 treated with Pinellia pedatisecta Schott extract[J].Oncol Rep,2016,36(1):462- 470.
[25] CHEN K,YANG X,WU L,et al.Pinellia pedatisecta agglutinin targets drug resistant K562/ADRleukemia cells through binding with sarcolemmal membrane associated protein and enhancingmacrophage phagocytosis[J].PLoS One,2013,8(9):e74363.
[26] WANG W,MAO S H,YU H L,et al.Pinellia pedatisecta lectin exerts a proinflammatory activity correlated with ROS- MAPKs/NF- κB pathways and the NLRP3 inflammasome in RAW264.7 cells accompanied by cell pyroptosis[J].Inter Immunophar,2019,66(1):1- 12.
[27] 张企兰,张如松,蒋惠娣,等.虎掌南星、白附片抗氧化作用的实验研究[J].中草药,1996,27(9):544- 546.
[28] 陈靖京,杨蓉,王明正,等.掌叶半夏超临界CO2乙醇萃取物的抗惊厥作用[J].中国药理学与毒理学杂志,2007,21(6):449- 454.
[29] 冯协和.掌叶半夏提取物抗衰老活性及作用机制研究[D].武汉:湖北中医药大学,2016.
[30] 毛淑杰,程立平,吴连,等.天南星(虎掌南星)抗惊厥作用探讨[J].中药材,2001,24(11):813- 814.
[31] 王义雄,苗小春.L- 缬氨酰- 缬氨酸酐对血液灌流犬离体窦房结和乳头状肌的作用[J].中国药理学报,1986,7(5):435- 438
[2] LEE J Y,PARK N H,LEE W,et al.Comprehensive chemical profiling of Pinellia species tuber and processed Pinellia tuber by gas chromatography- mass spectrometry and liquid chromatography- atmospheric pressure chemical ionization- tandem mass spectrometry[J].J Chromatogr A,2016,1471(11):164- 177.
[3] 陆丹,罗芬,池玉梅,等.高效液相色谱法同时测定中药材虎掌南星的核苷类成分[J].色谱,2011,29(1):83- 86.
[4] DU J,DING J,MU Z Q,et al.Three new alkaloids isolated from the stem tuber of Pinellia pedatisecta[J].Chin J Nat Med,2018,16(2):139- 142.
[5] 孙光星,丁声颂,钱瑶君.掌叶半夏凝集素A的分离纯化及分析[J].上海医科大学学报,1995,22(4):299- 302.
[6] LIU X,TIAN X,LIU T,et al.Disclosure of the tuberous lectin composed of homogeneous tetramers in Pinellia pedatisecda Schott [J].Appl Biochem Biotechnol,2010,162(4):1214- 1223.
[7] 满薇.天南星科植物虎掌南星的化学成分及天南星的质量控制研究[D].长春:长春中医药大学,2012.
[8] 栾阳,张慧,康廷国.掌叶半夏脂溶性成分GC- MS研究(气相色谱质谱联用仪)[J].中国实验方剂学杂志,2013,19(2):52- 54.
[9] 李桂玲,归绥琪,陈松华,等.掌叶半夏提取物的有效部位对体外培养宫颈癌细胞的促凋亡作用[J].中华中医药杂志,2008,23(5):447- 449.
[10] LI G L,JIANG W,XIA Q,et al.HPV E6 down- regulation and apoptosis induction of human cervical cancer cells by a novel lipid- soluble extract (PE)from Pinellia pedatisecta Schott in vitro[J].J Ethnopharmacol,2010,132(1):56- 64.
[11] 李桂玲,归绥琪,夏晴,等.掌叶半夏提取物的有效部位对CaSki的促凋亡作用机制研究[J].中华中医药杂志,2010,25(3):449- 452.
[12] 李桂玲,归绥琪,朱德厚,等.掌叶半夏有效提取物单独或与顺铂联合对体外培养宫颈癌HeLa细胞的作用[J].复旦学报(医学版),2007,34(6):869- 872.
[13] ZHANG M,YU Y,ZHANG H,et al.Syergistic cytotoxic effects of a combined treatment of a Pinellia pedatisecta lipid- soluble extract and cisplatin on human cervical carcinoma in vivo[J].Oncology Letters,2017,13(6):4748- 4754.
[14] ZHANG M,ZHANG H,YU Y,et al.Synergistic effects of a novel lipid- soluble extract from Pinellia pedatisecta Schott and cisplatin on human cervical carcinoma cell lines through the regulation of DNA damage response signaling pathway[J].Oncol Lett,2017,13(4):2121- 2128.
[15] 李桂玲.掌叶半夏有效提取物对宫颈癌细胞株的抑制作用及其机制研究[D].上海:复旦大学,2008:11- 29.
[16] HUANG H,ZHANG M,YAO S,et al.Immune modulation of a lipid- soluble extract of Pinellia pedatisecta Schott in the tumor microenvironment of an HPV+ tumor- burdened mouse model[J].J Ethnopharmacol,2018,225(10):103- 115.
[17] 黄海霞,张明星,张萌,等.掌叶半夏提取物对宫颈癌荷瘤小鼠脾脏免疫的作用[J].复旦学报(医学版),2016,43(5):534- 542.
[18] 牛娜.携带掌叶半夏凝集素基因的溶瘤腺病毒研究[D].杭州:浙江理工大学,2010.
[19] 李晓艳.携带掌叶半夏凝集素基因的溶瘤腺病毒在肝癌治疗中的体内外研究[D].杭州:浙江理工大学,2013.
[20] LU Q,LI N,LUO J,et al.Pinellia pedatisecta agglutinin interacts with the methylosome and induces cancer cell death[J].Oncogenesis,2012,1(10):e29.
[21] 朱铭伟,周抗美,丁声颂.掌叶半夏总蛋白对卵巢癌细胞株及人脐血造血细胞的作用[J].上海医科大学学报,1999,26(6):455- 456.
[22] 谷杭芝,郑飞云,周莉,等.掌叶半夏总蛋白诱导人卵巢癌SKOV3细胞凋亡的实验研究[J].海峡药学,2009,21(9):160- 162.
[23] 陈小燕,周莉,郑飞云,等.掌叶半夏总蛋白作用人卵巢癌SKOV3细胞的蛋白质组学研究[J].中国中西医结合杂志,2011,31(12):1651- 1656.
[24] ZHOU L,XU T,ZHANG Y,et al.Transcriptional network in ovarian cancer cell line SKOV3 treated with Pinellia pedatisecta Schott extract[J].Oncol Rep,2016,36(1):462- 470.
[25] CHEN K,YANG X,WU L,et al.Pinellia pedatisecta agglutinin targets drug resistant K562/ADRleukemia cells through binding with sarcolemmal membrane associated protein and enhancingmacrophage phagocytosis[J].PLoS One,2013,8(9):e74363.
[26] WANG W,MAO S H,YU H L,et al.Pinellia pedatisecta lectin exerts a proinflammatory activity correlated with ROS- MAPKs/NF- κB pathways and the NLRP3 inflammasome in RAW264.7 cells accompanied by cell pyroptosis[J].Inter Immunophar,2019,66(1):1- 12.
[27] 张企兰,张如松,蒋惠娣,等.虎掌南星、白附片抗氧化作用的实验研究[J].中草药,1996,27(9):544- 546.
[28] 陈靖京,杨蓉,王明正,等.掌叶半夏超临界CO2乙醇萃取物的抗惊厥作用[J].中国药理学与毒理学杂志,2007,21(6):449- 454.
[29] 冯协和.掌叶半夏提取物抗衰老活性及作用机制研究[D].武汉:湖北中医药大学,2016.
[30] 毛淑杰,程立平,吴连,等.天南星(虎掌南星)抗惊厥作用探讨[J].中药材,2001,24(11):813- 814.
[31] 王义雄,苗小春.L- 缬氨酰- 缬氨酸酐对血液灌流犬离体窦房结和乳头状肌的作用[J].中国药理学报,1986,7(5):435- 438
© 2004-2018 中国地质图书馆版权所有 京ICP备05064691号 京公网安备11010802017129号 地址：北京市海淀区学院路29号 邮编：100083 电话：办公室：(+86 10)66554848；文献借阅、咨询服务、科技查新：66554700 |