布拉氏酵母菌联合拉莫三嗪对小儿癫痫患者脑电、认知功能及血清DAO、D-LAC水平的影响
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摘要
目的 :探讨布拉氏酵母菌联合拉莫三嗪对小儿癫痫患者脑电、认知功能及血清二胺氧化酶(diamine oxidase,DAO)、D乳酸(D-lactose,D-LAC)水平的影响。方法 :选择本院2016年6月～2018年1月收治的130例小儿癫痫患者为研究对象,根据随机数字法将其分为观察组(n=70)和对照组(n=60)。同期选择本院收治的50例体检健康儿童作为健康组。对照组采用拉莫三嗪治疗,观察组患者采用布拉氏酵母菌联合拉莫三嗪治疗。治疗四周后比较两组患者疗效、脑电、认知功能以及血清DAO、D-LAC水平。结果 :治疗后,观察组患者总有效率为94.29%,显著高于对照组83.33%,两组比较差异有统计学意义。治疗后,两组患者θ频段相对功率与治疗前比较显著降低,且观察组患者θ频段相对功率明显低于对照组。治疗后,观察组患者认知功能水平显著高于对照组,两组比较差异有统计学意义。治疗后观察组患者血清DAO、D-LAC水平显著低于对照组,两组差异比较有统计学意义。结论 :布拉氏酵母菌联合拉莫三嗪治疗小儿癫痫患者,疗效显著,能显著改善患者脑电活动,改善认知功能和肠道功能,值得推广使用。
Objective To investigate the effects of yeast and lamotrigine on the brain, cognitive function and the level of serum two amine oxidase(diamine oxidase, DAO) and D lactate(D-lactose, D-LAC) in children with epilepsy. Methods 130 children with epilepsy were selected in our hospital from June 2016 to January 2018. According to the random number method,they were divided into observation group(n=70) and control group(n=60). At the same time, 50 healthy children who were admitted to our hospital were selected as healthy group. The control group was treated with lamotrigine, and the observation group was treated with the combination of Saccharomyces and Saccharomyces lamotrigine. After treatment, the efficacy, EEG, cognitive function and serum DAO and D-LAC levels of the two groups were compared. Results After treatment, the total effective rate of the observation group was 94.29%, which was significantly higher than that of the control group(83.33%). After treatment, the relative power of theta band in the two groups was significantly lower than that before treatment, and the relative power of theta band in the observation group was significantly lower than that in the control group. After treatment, the cognitive function level of patients in the observation group was significantly higher than that of the control group, and the difference between the two groups was statistically significant. After treatment, the serum DAO and D-LAC levels in the observation group were significantly lower than those in the control group, and the difference between the two groups was statistically significant. Conclusions The combination of Saccharomyces with lamotrigine and lamotrigine in the treatment of children with epilepsy has a significant effect. It can significantly improve the brain electrical activity and improve the cognitive function and intestinal function. It is worth popularizing.
Objective To investigate the effects of yeast and lamotrigine on the brain, cognitive function and the level of serum two amine oxidase(diamine oxidase, DAO) and D lactate(D-lactose, D-LAC) in children with epilepsy. Methods 130 children with epilepsy were selected in our hospital from June 2016 to January 2018. According to the random number method,they were divided into observation group(n=70) and control group(n=60). At the same time, 50 healthy children who were admitted to our hospital were selected as healthy group. The control group was treated with lamotrigine, and the observation group was treated with the combination of Saccharomyces and Saccharomyces lamotrigine. After treatment, the efficacy, EEG, cognitive function and serum DAO and D-LAC levels of the two groups were compared. Results After treatment, the total effective rate of the observation group was 94.29%, which was significantly higher than that of the control group(83.33%). After treatment, the relative power of theta band in the two groups was significantly lower than that before treatment, and the relative power of theta band in the observation group was significantly lower than that in the control group. After treatment, the cognitive function level of patients in the observation group was significantly higher than that of the control group, and the difference between the two groups was statistically significant. After treatment, the serum DAO and D-LAC levels in the observation group were significantly lower than those in the control group, and the difference between the two groups was statistically significant. Conclusions The combination of Saccharomyces with lamotrigine and lamotrigine in the treatment of children with epilepsy has a significant effect. It can significantly improve the brain electrical activity and improve the cognitive function and intestinal function. It is worth popularizing.
引文
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[8]刘超,王中琳.柴胡加龙骨牡蛎汤治疗脑卒中后癫痫的随机单盲对照研究[J].世界中医药, 2018, 13(09):2247-2250.
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[10]游勇,万静.布拉氏酵母菌散治疗小儿癫痫的临床疗效及其对肠道功能的影响[J].实用心脑肺血管病杂志, 2017, 25(10):107-109.
[11]常坷,尹泽黎,龚细礼.自发性脑出血后继发癫痫的临床研究[J].湖南师范大学学报, 2016, 13(04):22-24.
[12]刘芬,王莉.75例儿童额叶癫痫临床特点及视频脑电图特点分析[J].临床研究, 2018, 26(11):7-9.
[13] Croarkin P E, Thomas M A, Port J D, et al. N-acetylaspartate normalization in bipolar depression after lamotrigine treatment[J]. Bipolar Disorders, 2015, 17(4):450-457.
[14]韦迪岱,陈晋,郑文明.拉莫三嗪与丙戊酸钠对改善颅脑损伤后晚期癫痫疗效的比较[J].重庆医学, 2015, 44(22):3125-3126.
[15]杨琳,黄绍平.儿童难治性癫痫抗癫痫药物治疗策略[J].中国实用儿科杂志, 2016, 31(01):5-10.
[2]Patricia C, Abel C D, Eyal H. Evolving Electrocardiographic Changes in Lamotrigine Overdose:A Case Report and Literature Review[J]. Cardiovascular Toxicology, 2015, 15(4):1-5.
[3]王广新,杨作成.儿童难治性癫痫的临床特点分析[J].湖南师范大学学报, 2010, 7(04):16-18.
[4]贾建平,王荫华,李焰生,等.中国痴呆与认知障碍诊治指南(二):痴呆分型及诊断标准[J].中华医学杂志, 2011, 91(10):651-655.
[5]龚雪,周东,洪桢.肠道微生物与神经及精神疾病的研究现状[J].中国微生态学杂志, 2018, 30(03):350-357.
[6]卢燕,刘占利.肠道菌群和癫痫相关性研究进展[J].中华全科医学,2018, 16(09):1550-1553+1569.
[7]王莹莹,王洪伟,赵艳玲,等.情绪健康及生活质量与癫痫患者自杀的关系[J].中国健康心理学杂志, 2018, 26(04):493-496.
[8]刘超,王中琳.柴胡加龙骨牡蛎汤治疗脑卒中后癫痫的随机单盲对照研究[J].世界中医药, 2018, 13(09):2247-2250.
[9]王小蛰,凌云.拉莫三嗪联合丙戊酸钠治疗癫痫的临床应用[J].实用中西医结合临床, 2018, 18(08):58-60.
[10]游勇,万静.布拉氏酵母菌散治疗小儿癫痫的临床疗效及其对肠道功能的影响[J].实用心脑肺血管病杂志, 2017, 25(10):107-109.
[11]常坷,尹泽黎,龚细礼.自发性脑出血后继发癫痫的临床研究[J].湖南师范大学学报, 2016, 13(04):22-24.
[12]刘芬,王莉.75例儿童额叶癫痫临床特点及视频脑电图特点分析[J].临床研究, 2018, 26(11):7-9.
[13] Croarkin P E, Thomas M A, Port J D, et al. N-acetylaspartate normalization in bipolar depression after lamotrigine treatment[J]. Bipolar Disorders, 2015, 17(4):450-457.
[14]韦迪岱,陈晋,郑文明.拉莫三嗪与丙戊酸钠对改善颅脑损伤后晚期癫痫疗效的比较[J].重庆医学, 2015, 44(22):3125-3126.
[15]杨琳,黄绍平.儿童难治性癫痫抗癫痫药物治疗策略[J].中国实用儿科杂志, 2016, 31(01):5-10.
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