薏苡化学成分与药理作用研究概况
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摘要
本文通过查阅国内外数据库中薏苡化学成分与药理作用的相关文献,对薏苡整个植物所含化学成分与药理作用进行了详细的总结。薏苡含有脂肪酸及其脂类、黄酮类、酰胺类、甾醇类、萜类、多糖和生物碱等多种化合物,薏苡药理作用广泛,包括抗肿瘤、增强免疫、降血糖、抗炎、镇痛、抗菌和抗氧化等作用。通过本文,人们可以更加全面地了解薏苡,为进一步研究薏苡药理作用及其所含化合物的构效关系、作用机制提供一定的参考依据。
In this article, the relevant literatures on the chemical constituents and pharmacological activities of Coix lachryma-jobi L. are reviewed. And the chemical constituents and pharmacological effects of the whole plant of Coix lachryma-jobi L. are summarized in detail. The Coix lachryma-jobi L. contain fatty acids and their lipids, flavonoids,amides, sterols, terpenoids, polysaccharides and alkaloids. The Coix lachryma-jobi L. has a wide range of pharmacological effects, including anti-tumor, immunity enhancement, hpyerglycemic, anti-inflammatory, analgesic, antiseptic and antioxidant effects. Through this review, people can have a better understanding of Coix lachryma-jobi L.. It can provide some reference for further study on the relationship between the pharmacological action of Coix lachryma-jobi L.and the structure activity relationship and mechanism of the compounds.
In this article, the relevant literatures on the chemical constituents and pharmacological activities of Coix lachryma-jobi L. are reviewed. And the chemical constituents and pharmacological effects of the whole plant of Coix lachryma-jobi L. are summarized in detail. The Coix lachryma-jobi L. contain fatty acids and their lipids, flavonoids,amides, sterols, terpenoids, polysaccharides and alkaloids. The Coix lachryma-jobi L. has a wide range of pharmacological effects, including anti-tumor, immunity enhancement, hpyerglycemic, anti-inflammatory, analgesic, antiseptic and antioxidant effects. Through this review, people can have a better understanding of Coix lachryma-jobi L.. It can provide some reference for further study on the relationship between the pharmacological action of Coix lachryma-jobi L.and the structure activity relationship and mechanism of the compounds.
引文
[1]钟赣生.中药学[M].北京:中国中医药出版社,2012:193-194.
[2] Apirattananusorn S,Tongta S,Cui SW,et al. Chemical,molecular,and structural characterization of alkali extractable nonstarch polysaccharides from Job′s tears[J]. J Agric Food Chem,2008,56(18):8549-8557.
[3]赵为武,李俊,郭晓关,等.薏苡仁提取油的成分分析[J].安徽农业科学,2014,42(1):257-258,305.
[4]杨爽,王李梅,王姝麒,等.薏苡化学成分及其活性综述[J].中药材,2011,34(8):1306-1312.
[5]黄锁义,李容,潘勇,等.薏苡研究的新进展[J].食品研究与开发,2012,33(11):223-227.
[6] Ukita T,Tanimura A. Studies on the Anti-tumor Component in the Seeds of Coix Lachryma-Jobi L. VAR. Mayuen(ROMAN.)STAPF. I.:Isolation and Anti-tumor Activity of Coixenolide[J]. Chem Pharm Bull,2008,9(1):43-46.
[7] Tokuda H,Matsumoto T,Konoshima T,et al. Inhibitory effects on Epstein-Barr virus activation and anti-tumor promoting activities of Coix seed[J]. Planta Med,1990,56(6):653-654.
[8]雷正杰,张忠义,王鹏,等.薏苡仁油脂肪酸组成分析[J].中药材,1999,22(8):405.
[9] Lee MY,Lin HY,Cheng F,et al. Isolation and characterization of new lactam compounds that inhibit lung and colon cancer cells from adlay(Coix lachryma-jobi L. var.ma-yuen Stapf)bran[J]. Food Chem Toxicol,2008,46(6):1933-1939.
[10] Chung CP,Hsu CY,Lin JH,et al. Antiproliferative lactams and spiroenone from adlay bran in human breast cancer cell lines[J]. J Agric Food Chem,2011,59(4):1185-1194.
[11] Huang DW,Chung CP,Kuo YH,et al. Identification of compounds in adlay(Coix lachryma-jobi L. var. ma-yuen Stapf)seed hull extracts that inhibit lipopolysaccharideinduced inflammation in RAW 264.7 macrophages[J]. J Agric Food Chem,2009,57(22):10651-10657.
[12] Satoshi K,Naolki I,Takamasa S,et al. Studies on the constituents of seed of Coix lacryma-jobi L[J]. Nippon Kagakkai Koen Yokoshu,1998,75:225.
[13]谭冰,黄锁义,严焕宁,等.薏苡叶化学成分的预试验[J].食品研究与开发,2014,35(10):6-8.
[14]史柳芝,史恒芝,谭冰,等.薏苡茎化学成分预试验研究[J].微量元素与健康研究,2013,30(6):24-26.
[15] Chen HJ,Chung CP,Chiang W,et al. Anti-inflammatory effects and chemical study of a flavonoid-enriched fraction from adlay bran[J]. Food Chem,2011,126(4):1741-1748.
[16]樊青玲,张平,任旻琼.薏苡的化学成分、药理活性及应用研究进展[J].天然产物研究与开发,2015,27(10):1831-1835.
[17]黄娇,范世明,陈丹,等.闽产薏苡种皮与薏苡仁的化学成分分析[J].福建中医药,2016,47(5):18-20.
[18]八木晟.薏苡仁的抗癌消炎活性[J].国外医药·植物药分册,1989,4(2):75-77.
[19]朱晓莹,林瑶,黄锁义,等.薏苡茎叶提取物的体外抗肿瘤活性研究[J].时珍国医国药,2014,25(4):782-783.
[20]黄挺章,李远辉,郭圣奇,等.薏苡茎醇提取物对荷H22小鼠体内抗肿瘤作用[J].天津医药,2015,43(11):1278-1281.
[21]郭圣奇,黄挺章,李远辉,等.薏苡茎水提取物对H22荷瘤小鼠的抗肿瘤作用研究[J].中国临床药理学杂志,2015,31(10):855-857.
[22]林瑶,李津,覃永长,等.薏苡叶的体内抗肿瘤S180实验研究[J].中国医院药学杂志,2015,35(15):1357-1359.
[23]林瑶,陆世惠,喻巧容,等.薏苡茎叶提取物石油醚部位的体外抗肿瘤活性研究[J].中国临床药理学杂志,2018,34(3):282-284.
[24]张明发,沈雅琴.薏苡仁的生殖系统和抗性器官肿瘤药理作用研究进展[J].现代药物与临床,2012,27(3):309-312.
[25]韩苏夏,朱青,杜蓓茹,等.薏苡仁酯诱导人宫颈癌HeLa细胞凋亡的实验研究[J].肿瘤,2002,22(6):481-482.
[26]李毓,胡笑克.薏苡仁酯对人鼻咽癌细胞裸鼠移植瘤的放射增敏作用[J].华夏医学,2005,18(2):147-148.
[27]张明发,沈雅琴.薏苡仁油抗头颈部癌的药理作用和临床应用研究进展[J].现代药物与临床,2012,27(2):171-175.
[28]王彦芳,季旭明,赵海军,等.薏苡仁多糖不同组分对脾虚水湿不化大鼠模型免疫功能的影响[J].中华中医药杂志,2017,32(3):1303-1306.
[29]屈中玉,陶海云,李印,等.注射用薏苡仁油对大肠癌术后患者免疫功能及无进展生存期的影响[J].中医学报,2017,32(7):1161-1164.
[30]徐梓辉,周世文,黄林清.薏苡仁多糖的分离提取及其降血糖作用的研究[J].第三军医大学学报,2000,22(6):578-581.
[31]吴建方.薏苡仁提取物的抗炎、镇痛、镇静作用研究[J].转化医学电子杂志,2015,2(12):56-57.
[32]郑红霞,章伟明,周红娟,等.薏苡仁酯对胶原诱导性关节炎小鼠Foxp3+CD4+CD25+调节性T细胞影响的研究[J].中国中西医结合杂志,2016,36(3):348-350.
[33]岳静.薏苡仁及其组分对类风湿关节炎大鼠抗炎作用研究[D].济南:山东中医药大学,2017.
[34]罗继.薏苡抗菌蛋白组的分离鉴定[D].成都:四川师范大学,2008.
[35]覃丽,蓝琳云,张强,等.薏苡茎多酚的体外抗氧化活性研究[J].食品工业,2017,38(12):177-179.
[36]陈雯静,黄锁义,喻巧容,等.不同极性薏苡茎提取物的抗氧化活性研究[J].食品工业,2017,38(6):104-106.
[2] Apirattananusorn S,Tongta S,Cui SW,et al. Chemical,molecular,and structural characterization of alkali extractable nonstarch polysaccharides from Job′s tears[J]. J Agric Food Chem,2008,56(18):8549-8557.
[3]赵为武,李俊,郭晓关,等.薏苡仁提取油的成分分析[J].安徽农业科学,2014,42(1):257-258,305.
[4]杨爽,王李梅,王姝麒,等.薏苡化学成分及其活性综述[J].中药材,2011,34(8):1306-1312.
[5]黄锁义,李容,潘勇,等.薏苡研究的新进展[J].食品研究与开发,2012,33(11):223-227.
[6] Ukita T,Tanimura A. Studies on the Anti-tumor Component in the Seeds of Coix Lachryma-Jobi L. VAR. Mayuen(ROMAN.)STAPF. I.:Isolation and Anti-tumor Activity of Coixenolide[J]. Chem Pharm Bull,2008,9(1):43-46.
[7] Tokuda H,Matsumoto T,Konoshima T,et al. Inhibitory effects on Epstein-Barr virus activation and anti-tumor promoting activities of Coix seed[J]. Planta Med,1990,56(6):653-654.
[8]雷正杰,张忠义,王鹏,等.薏苡仁油脂肪酸组成分析[J].中药材,1999,22(8):405.
[9] Lee MY,Lin HY,Cheng F,et al. Isolation and characterization of new lactam compounds that inhibit lung and colon cancer cells from adlay(Coix lachryma-jobi L. var.ma-yuen Stapf)bran[J]. Food Chem Toxicol,2008,46(6):1933-1939.
[10] Chung CP,Hsu CY,Lin JH,et al. Antiproliferative lactams and spiroenone from adlay bran in human breast cancer cell lines[J]. J Agric Food Chem,2011,59(4):1185-1194.
[11] Huang DW,Chung CP,Kuo YH,et al. Identification of compounds in adlay(Coix lachryma-jobi L. var. ma-yuen Stapf)seed hull extracts that inhibit lipopolysaccharideinduced inflammation in RAW 264.7 macrophages[J]. J Agric Food Chem,2009,57(22):10651-10657.
[12] Satoshi K,Naolki I,Takamasa S,et al. Studies on the constituents of seed of Coix lacryma-jobi L[J]. Nippon Kagakkai Koen Yokoshu,1998,75:225.
[13]谭冰,黄锁义,严焕宁,等.薏苡叶化学成分的预试验[J].食品研究与开发,2014,35(10):6-8.
[14]史柳芝,史恒芝,谭冰,等.薏苡茎化学成分预试验研究[J].微量元素与健康研究,2013,30(6):24-26.
[15] Chen HJ,Chung CP,Chiang W,et al. Anti-inflammatory effects and chemical study of a flavonoid-enriched fraction from adlay bran[J]. Food Chem,2011,126(4):1741-1748.
[16]樊青玲,张平,任旻琼.薏苡的化学成分、药理活性及应用研究进展[J].天然产物研究与开发,2015,27(10):1831-1835.
[17]黄娇,范世明,陈丹,等.闽产薏苡种皮与薏苡仁的化学成分分析[J].福建中医药,2016,47(5):18-20.
[18]八木晟.薏苡仁的抗癌消炎活性[J].国外医药·植物药分册,1989,4(2):75-77.
[19]朱晓莹,林瑶,黄锁义,等.薏苡茎叶提取物的体外抗肿瘤活性研究[J].时珍国医国药,2014,25(4):782-783.
[20]黄挺章,李远辉,郭圣奇,等.薏苡茎醇提取物对荷H22小鼠体内抗肿瘤作用[J].天津医药,2015,43(11):1278-1281.
[21]郭圣奇,黄挺章,李远辉,等.薏苡茎水提取物对H22荷瘤小鼠的抗肿瘤作用研究[J].中国临床药理学杂志,2015,31(10):855-857.
[22]林瑶,李津,覃永长,等.薏苡叶的体内抗肿瘤S180实验研究[J].中国医院药学杂志,2015,35(15):1357-1359.
[23]林瑶,陆世惠,喻巧容,等.薏苡茎叶提取物石油醚部位的体外抗肿瘤活性研究[J].中国临床药理学杂志,2018,34(3):282-284.
[24]张明发,沈雅琴.薏苡仁的生殖系统和抗性器官肿瘤药理作用研究进展[J].现代药物与临床,2012,27(3):309-312.
[25]韩苏夏,朱青,杜蓓茹,等.薏苡仁酯诱导人宫颈癌HeLa细胞凋亡的实验研究[J].肿瘤,2002,22(6):481-482.
[26]李毓,胡笑克.薏苡仁酯对人鼻咽癌细胞裸鼠移植瘤的放射增敏作用[J].华夏医学,2005,18(2):147-148.
[27]张明发,沈雅琴.薏苡仁油抗头颈部癌的药理作用和临床应用研究进展[J].现代药物与临床,2012,27(2):171-175.
[28]王彦芳,季旭明,赵海军,等.薏苡仁多糖不同组分对脾虚水湿不化大鼠模型免疫功能的影响[J].中华中医药杂志,2017,32(3):1303-1306.
[29]屈中玉,陶海云,李印,等.注射用薏苡仁油对大肠癌术后患者免疫功能及无进展生存期的影响[J].中医学报,2017,32(7):1161-1164.
[30]徐梓辉,周世文,黄林清.薏苡仁多糖的分离提取及其降血糖作用的研究[J].第三军医大学学报,2000,22(6):578-581.
[31]吴建方.薏苡仁提取物的抗炎、镇痛、镇静作用研究[J].转化医学电子杂志,2015,2(12):56-57.
[32]郑红霞,章伟明,周红娟,等.薏苡仁酯对胶原诱导性关节炎小鼠Foxp3+CD4+CD25+调节性T细胞影响的研究[J].中国中西医结合杂志,2016,36(3):348-350.
[33]岳静.薏苡仁及其组分对类风湿关节炎大鼠抗炎作用研究[D].济南:山东中医药大学,2017.
[34]罗继.薏苡抗菌蛋白组的分离鉴定[D].成都:四川师范大学,2008.
[35]覃丽,蓝琳云,张强,等.薏苡茎多酚的体外抗氧化活性研究[J].食品工业,2017,38(12):177-179.
[36]陈雯静,黄锁义,喻巧容,等.不同极性薏苡茎提取物的抗氧化活性研究[J].食品工业,2017,38(6):104-106.
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