基于因子分析和复杂网络技术的溃疡性结肠炎证素分布特点研究
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摘要
目的探讨因子分析和复杂网络技术用于溃疡性结肠炎中医证候研究的价值。方法采用自拟《溃疡性结肠炎中医证候流行病学调查表》收集706例溃疡性结肠炎患者的中医症状体征和舌脉表现,并行因子分析和复杂网络技术分析。结果经因子分析、复杂网络技术相结合提取出证素12个,病位证素包括肠、脾、肝、肾,病性证素包括湿热、寒湿、风寒、气滞、气虚、阳虚、阴虚、血瘀,常见证候类型为寒滞胃肠证、大肠湿热证、寒湿内盛证、脾胃虚弱证、肝郁脾虚证、脾肾阳虚证、阴虚肠燥证、血瘀肠络证。结论因子分析和复杂网络技术相结合的数理统计方法可用于溃疡性结肠炎证候证素分布特点研究,更能直观、简洁地阐明该病的证候特点,为该病的证候研究提供了一种新的方法。
Objective It is to explore the value of application of factor analysis and complex network technology for the study of syndrome of traditional Chinese medicine in ulcerative colitis. Methods The TCM symptoms and signs and tongue and pulse manifestations of 706 patients with ulcerative colitis were collected by self-made epidemiological questionnaire of TCM syndromes of ulcerative colitis,and were analyzed by factor analysis and complex network technology analysis. Results A total of 12 syndromes were extracted by factor analysis and complex network technology. Disease syndrome factors: intestinal, spleen, liver and kidney. The nature syndrome elements:dampness-heat, cold-dampness, wind-cold, Qi stagnation, Qi deficiency, Yang deficiency, Yin deficiency, blood stasis. The common syndrome types: cold stagnation gastrointestinal syndrome, large intestine damp-heat syndrome, cold-dampness syndrome, spleen-stomach weakness syndrome, liver depression and spleen deficiency syndrome, spleen-kidney Yang deficiency syndrome, Yin deficiency intestinal dryness syndrome and blood stasis intestinal collateral syndrome. Conclusion The mathematical statistics method combining factor analysis and complex network technology can be used to study the distribution characteristics of syndrome elements in ulcerative colitis. It can be more intuitively and succinctly clarified the syndrome characteristics of the disease, and provides a new idea for the study of TCM syndrome in this disease.
Objective It is to explore the value of application of factor analysis and complex network technology for the study of syndrome of traditional Chinese medicine in ulcerative colitis. Methods The TCM symptoms and signs and tongue and pulse manifestations of 706 patients with ulcerative colitis were collected by self-made epidemiological questionnaire of TCM syndromes of ulcerative colitis,and were analyzed by factor analysis and complex network technology analysis. Results A total of 12 syndromes were extracted by factor analysis and complex network technology. Disease syndrome factors: intestinal, spleen, liver and kidney. The nature syndrome elements:dampness-heat, cold-dampness, wind-cold, Qi stagnation, Qi deficiency, Yang deficiency, Yin deficiency, blood stasis. The common syndrome types: cold stagnation gastrointestinal syndrome, large intestine damp-heat syndrome, cold-dampness syndrome, spleen-stomach weakness syndrome, liver depression and spleen deficiency syndrome, spleen-kidney Yang deficiency syndrome, Yin deficiency intestinal dryness syndrome and blood stasis intestinal collateral syndrome. Conclusion The mathematical statistics method combining factor analysis and complex network technology can be used to study the distribution characteristics of syndrome elements in ulcerative colitis. It can be more intuitively and succinctly clarified the syndrome characteristics of the disease, and provides a new idea for the study of TCM syndrome in this disease.
引文
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[2] Troncone E,Monteleone G.The safety of non-biological treatments in Ulcerative Colitis[J].Expert Opin Drug Saf,2017,16(7):779-789
[3] 王建云,王新月,孙慧怡,等.溃疡性结肠炎患者血清及结肠组织α1-抗胰蛋白酶水平与肺功能损害相关性研究[J].中国中西医结合杂志,2014,34(1):20-26
[4] 李毅,刘艳,刘力,等.溃疡性结肠炎症状学聚类研究[J].现代中西医结合杂志,2016,25(4):1027-1029
[5] 李毅,刘艳,刘力,等.溃疡性结肠炎中医症状学主成分分析[J].中医药导报,2016,22(7):32-35
[6] 李毅,刘艳,刘力,等.基于多元统计方法对溃疡性结肠炎辨证标准的研究[J].中医药导报,2016,22(12):42-47
[7] 中华医学会消化病学分会炎症性肠病协作组.对我国炎症性肠病诊断治疗规范的共识意见(2007年,济南)[J].中华消化杂志,2007,27(8):545-550
[8] 国家中医药管理局.中药新药临床研究指导原则[S].北京:中国医药科技出版社,2002:129-133
[9] 全国科学技术名词审定委员会.中医药学名词2004[S].北京:科学出版社,2005:81-108
[10] 国家中医药管理局.中医病证诊断疗效标准[S].北京:中国医药科技出版社,2002:107-110
[11] 朱文锋.中医诊断学[M].北京:人民卫生出版社,2004:176-208
[12] 曾光.现代流行病学方法与应用[M].北京:北京医科大学中国协和医科大学联合出版社,1994:13-32
[13] 蒋知俭.医学统计学[M].北京:人民卫生出版社,1997:253-256
[14] 李毅.消化性溃疡中医辨证规律及辨证治疗的临床研究[D].长沙:湖南中医药大学,2009:40-41
[15] 李毅,张小萍.消化性溃疡中医证候的因子分析[J].时珍国医国药,2010,21(12):3379-3380
[16] 史琦,陈建新,赵慧辉,等.基于复杂网络技术的冠心病患者四诊信息分布模式的研究[J].北京中医药大学学报,2012,35(3):183-188
[17] 师宁,陈建新,刘敏,等.基于因子分析和复杂网络技术的反流性食管炎证素分布特点研究[J].中华中医药杂志,2015,30(1):66-69
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