三酰甘油与高密度脂蛋白胆固醇比值在2型糖尿病周围神经病变中的价值研究
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摘要
目的探讨三酰甘油与高密度脂蛋白胆固醇比值在2型糖尿病周围神经病变中的临床价值。方法连续收集II型糖尿病患者301例,包括周围神经病变(DPN)组75例和非周围神经病变(NDPN)组226例,记录2型糖尿病病程,测量患者血压,计算体质量指数(BMI),入院当日空腹采静脉血检测血清大生化指标和糖化血红蛋白,并以健康体检者38例作为正常对照组,筛选DPN发生的独立危险因子。结果 DPN和NDPN组的年龄、糖尿病程、肌酐、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇差异均有统计学意义(均<0.05)。随着糖尿病周围神经病变的发生,三酰甘油与HDL-C比值(TG/HDL-C)逐渐显著升高(均<0.05)。年龄和TG/HDL-C是影响DPN发生的独立危险因子(均<0.05)。结论 2型糖尿病患者TG/HDL-C较正常人明显升高,是导致糖尿病周围神经病变发生的独立危险因子。
引文
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[5]张红军.2型糖尿病性视网膜病变相关影响因素分析[D].海军军医大学,2018:1-58.
[6]董文婿,蒋煌舟,唐宝佳.三酰甘油和高密度脂蛋白比值与糖尿病肾病的相关性[J].糖尿病新世界,2018,21(1):178-179.
[7] Dobiasova M, Frohlich J. The plasma parameter log(TG/HDL-C)as an atherogenic index:correlation with lipoprotein particle size and esterification rate inapob-lipoprotein-depleted plasma(FERHDL)[J]. Clinical Biochemistry,2001,34(7):583.
[8]范雪松,王恩世,贺建勋,等.小而密低密度脂蛋白胆固醇及其与低密度脂蛋白胆固醇之比与颈动脉粥样硬化斑块的关系[J].中华检验医学杂志,2018,41(3):219-226.
[2] Cleary PP, Feldman AL, Herman WH, et al.Effects of prior intensive insulin therapy on cardiac autonomic nervous system function in type 1 diabetes mellitus:the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications study(DCCT/EDIC)[J].Circulation, 2009,119(22):2886-2893.
[3] Leiter LA. The prevention of diabetic microvascular complications of diabetes:is there a role for lipid lowering[J]? Diabetes Res Clin Pract,2005, 68(1):S3-S14.
[4] Isomaa B, Henricsson M, Almgren P, et al.The metabolic syndrome influences the risk of chronic complications in patients with Type II diabetes[J].Diabetologia,2001, 44(9):1148-1154.
[5]张红军.2型糖尿病性视网膜病变相关影响因素分析[D].海军军医大学,2018:1-58.
[6]董文婿,蒋煌舟,唐宝佳.三酰甘油和高密度脂蛋白比值与糖尿病肾病的相关性[J].糖尿病新世界,2018,21(1):178-179.
[7] Dobiasova M, Frohlich J. The plasma parameter log(TG/HDL-C)as an atherogenic index:correlation with lipoprotein particle size and esterification rate inapob-lipoprotein-depleted plasma(FERHDL)[J]. Clinical Biochemistry,2001,34(7):583.
[8]范雪松,王恩世,贺建勋,等.小而密低密度脂蛋白胆固醇及其与低密度脂蛋白胆固醇之比与颈动脉粥样硬化斑块的关系[J].中华检验医学杂志,2018,41(3):219-226.