香砂六君子汤加减辅助治疗减轻乳腺癌化疗患者化疗相关不良反应效果观察
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摘要
目的探讨香砂六君子汤加减辅助治疗对乳腺癌化疗患者化疗相关不良反应的影响。方法选取2017年1月至2018年12月我院收治的乳腺癌患者80例为研究对象,分为观察组与对照组,每组40例。对照组患者在化疗期间给予托烷司琼治疗,观察组患者在对照组治疗基础上加用香砂六君子汤加减治疗。比较两组患者化疗期间的毒副反应及严重程度;比较化疗前后两组患者的生活质量(躯体状况、社会/家庭状况、情感状况、功能状况、附加关注)评分。结果观察组患者化疗期间恶心呕吐、白细胞计数下降的严重程度明显轻于对照组,差异有统计学意义(P <0. 05)。化疗第10天,两组患者的躯体状况、社会/家庭状况、情感状况评分均显著提高,观察组患者这三个维度的评分均显著高于对照组,差异有统计学意义(P <0. 05)。结论香砂六君子汤加减辅助治疗可显著减轻乳腺癌化疗患者化疗期间的毒副反应,明显提高患者的生活质量,具有较高的临床应用价值。
Objective To explore the effect of modified Xiangsha Liujunzi Decoction on chemotherapy-related adverse reactions in patients with breast cancer chemotherapy. Methods 80 patients with breast cancer admitted to our hospital from January 2017 to December 2018 were enrolled and divided into observation group and control group,with40 cases in each group. Patients in the control group were treated with tropisetron during chemotherapy. Patients in the observation group were treated with modified Xiangsha Liujunzi Decoction on the basis of the treatment of the control group.The symptoms and severity of toxic side effects during chemotherapy in the two groups were compared. The quality of life( physical status,social/family status,emotional status,functional status,additional attention) scores of the two groups before and after chemotherapy were compared. Results The severity of nausea and vomiting and the decrease of white blood cell count in the observation group during chemotherapy were significantly less than that in the control group,and the difference was statistically significant( P < 0. 05). On the 10 th day of chemotherapy,the physical status,social/family status,and emotional status scores of the two groups were significantly improved,and the scores of these three dimensions in the observation group were significantly higher than the control group,and the difference was statistically significant( P < 0. 05). Conclusion Modified Xiangsha Liujunzi Decoction can significantly reduce the toxic side effects during chemotherapy in patients with breast cancer chemotherapy,and significantly improve the life quality of patients. It has high clinical application value.
Objective To explore the effect of modified Xiangsha Liujunzi Decoction on chemotherapy-related adverse reactions in patients with breast cancer chemotherapy. Methods 80 patients with breast cancer admitted to our hospital from January 2017 to December 2018 were enrolled and divided into observation group and control group,with40 cases in each group. Patients in the control group were treated with tropisetron during chemotherapy. Patients in the observation group were treated with modified Xiangsha Liujunzi Decoction on the basis of the treatment of the control group.The symptoms and severity of toxic side effects during chemotherapy in the two groups were compared. The quality of life( physical status,social/family status,emotional status,functional status,additional attention) scores of the two groups before and after chemotherapy were compared. Results The severity of nausea and vomiting and the decrease of white blood cell count in the observation group during chemotherapy were significantly less than that in the control group,and the difference was statistically significant( P < 0. 05). On the 10 th day of chemotherapy,the physical status,social/family status,and emotional status scores of the two groups were significantly improved,and the scores of these three dimensions in the observation group were significantly higher than the control group,and the difference was statistically significant( P < 0. 05). Conclusion Modified Xiangsha Liujunzi Decoction can significantly reduce the toxic side effects during chemotherapy in patients with breast cancer chemotherapy,and significantly improve the life quality of patients. It has high clinical application value.
引文
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[13]韩惠萍,张丽娇,董洁晨,等.洛哌丁胺联合香砂六君子汤灌肠治疗伊立替康化疗后腹泻合并肠源性细菌感染的疗效及对血清炎性标记物的影响[J].现代中西医结合杂志,2017,26(36):4014-4016.
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[3]张锡贵,李太东,倪武,等.早期乳腺癌保乳手术联合放化疗治疗方案的临床研究[J].中国现代普通外科进展,2015,18(9):709-711.
[4]肖永刚.香砂六君子汤对腹腔镜结肠癌根治术后胃肠功能恢复的影响[J].中国现代普通外科进展,2018,21(1):43-44.
[5]中华人民共和国国家卫生和计划生育委员会.原发性乳腺癌规范化诊疗指南(试行)[J].慢性病学杂志,2013,5(5):30-37.
[6]刘丹,谢枫枫,陈莹.香砂六君子汤对乳腺癌化疗患者的减毒及增效作用观察[J].湖南中医药大学学报,2018,38(4):455-458.
[7]张雅琳,张静.有氧运动结合松弛疗法对乳腺癌化疗病人症状群和生活质量的影响[J].护理研究,2016,30(22):2764-2767.
[8]丁红,施伟伟,王治宽,等.阿瑞匹坦联合托烷司琼治疗化疗所致恶心呕吐的回顾性分析[J].癌症进展,2017,15(4):408-410,431.
[9]丁笑笑,丁新华.奥氮平联合托烷司琼、地塞米松预防高致吐风险药物化疗引起恶心、呕吐的疗效分析[J].医学研究杂志,2015,44(5):143-146.
[10]樊英华.香砂六君子汤配合化疗治疗结肠癌临床观察[J].陕西中医,2016,37(8):955-956.
[11]许杜娟,陈敏珠.黄芪总提物减弱荷瘤小鼠化疗引起的白细胞减少和免疫抑制作用[J].安徽中医药大学学报,2006,25(3):34-36.
[12]佟玉涛,李庆芬,李丽艳,等.甘麦大枣汤治疗妇科恶性肿瘤放化疗后白细胞减少症临床研究[J].中医学报,2015,30(5):624-625.
[13]韩惠萍,张丽娇,董洁晨,等.洛哌丁胺联合香砂六君子汤灌肠治疗伊立替康化疗后腹泻合并肠源性细菌感染的疗效及对血清炎性标记物的影响[J].现代中西医结合杂志,2017,26(36):4014-4016.
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