儿童急性阑尾炎抗感染方案的研究进展
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摘要
儿童急性阑尾炎是学龄儿童常见病之一。治疗方法主要有手术治疗和保守治疗,腹腔镜下阑尾切除术成为主要的手术方式。由于抗菌药物在外科领域中的不合理应用相当普遍,近年来越来越多的药师参与到临床用药中。据文献报道,药师对临床用药的干预是有效可行的,能更好地促进临床合理用药。本文就儿童急性阑尾炎抗感染方案的研究作一综述。
Acute appendicitis is one of the common diseases in school-age children. The main treatments are surgical treatment and conservative treatment, and the main operative method is laparoscopic appendectomy. As the irrational use of antibacterial drugs in surgical departments is quite common, more and more pharmacists have participated in clinical drug use recently. The intervention of clinical drug use is reported to be effective and feasible, which could promote rational clinical drug use. This article reviews the research on anti-infective programs for children with acute appendicitis.
Acute appendicitis is one of the common diseases in school-age children. The main treatments are surgical treatment and conservative treatment, and the main operative method is laparoscopic appendectomy. As the irrational use of antibacterial drugs in surgical departments is quite common, more and more pharmacists have participated in clinical drug use recently. The intervention of clinical drug use is reported to be effective and feasible, which could promote rational clinical drug use. This article reviews the research on anti-infective programs for children with acute appendicitis.
引文
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[2]Hansson J,Khorram-Manesh A,Alwindawe A,et al.A model to select patients who may benefit from antibiotic therapy as the first line treatment of acute appendicitis at high probability[J].J Gastrointest Surg,2014,18(5):961-7.
[3]Chan KW,Lee KH,Mou JW,et al.Evidence-based adjustment of antibiotic in pediatric complicated appendicitis in the era of antibiotic resistance[J].Pediatr Surg Int,2010,26(2):157-60.
[4]Jeon HG,Ju HU,Kim GY,et al.Bacteriology and changes in antibiotic susceptibility in adults with community-acquired perforated appendicitis[J].PLoS One,2014,9(10):e111144.
[5]方莉,周敬.儿童阑尾炎的临床及病理特点分析[J].医学信息,2014,27(8):192-3.
[6]Kim YS,Kim Y,Cho OK,et al.Sonography for right lower quadrant pain[J].J Clin Ultrasound,2001,29(3):157-85.
[7]Himeno S,Yasuda S,Oida Y,et al.Ultrasonography for the diagnosis of acute appendicitis[J].Tokai J Exp Clin Med,2003,28(1):39-44.
[8]Andersson RE.Routine ultrasound and limited computed tomography for the diagnosis of acute appendicitis:a surgeon's perspective[J].World J Surg,2011,35(2):295-6.
[9]Dohan A,Soyer P.Low-dose abdominal CT for diagnosing appendicitis[J].N Engl J Med,2012,367(5):477.
[10]Al-Ajerami Y.Sensitivity and specificity of ultrasound in the diagnosis of acute appendicitis[J].East Mediterr Health J,2012,18(1):66-9.
[11]Taourel P,Baron MP,Pradel J,et al.Acute abdomen of unknown origin:impact of CT on diagnosis and management[J].Gastrointest Radiol,1992,17(4):287-91.
[12]Linton OW,Mettler FA Jr;National Council on Radiation Protection and Measurements.National conference on dose reduction in CT,with an emphasis on pediatric patients[J].AJR Am JRoentgenol,2003,181(2):321-9.
[13]Dorfman AL,Fazel R,Einstein AJ,et al.Use of medical imaging procedures with ionizing radiation in children:a population-based study[J].Arch Pediatr Adolesc Med,2011,165(5):458-64.
[14]Rezak A,Abbas HM,Ajemian M S,et al.Decreased use of computed tomography with a modified clinical scoring system in diagnosis of pediatric acute appendicitis[J].Arch Surg,2011,146(1):64-7.
[15]夏禹,黄瑛,富聪聪,等.超声与CT诊断小儿急慢性阑尾炎的对比分析[J].中国临床医学影像杂志,2014,25(11):793-6.
[16]罗新伟.儿童急性阑尾炎临床及病理特点观察[J].中国医药导报,2012,9:174-5.
[17]顾秀文,金先庆,李晓庆,等.1 179例小儿穿孔性阑尾炎的临床分析[J].重庆医学,2010,39(17):2357-8,2361.
[18]孙松,Basnet BM,郑珊,等.不同年龄小儿穿孔性阑尾炎流行病学及临床表现差异分析[J].中华小儿外科杂志,2013,34(11):814-8.
[19]舒发.小儿阑尾炎临床特点及病原学分析[D].重庆医科大学,2015.
[20]周以明,印其友,肖现民.小儿穿孔性阑尾炎致病菌群特点及抗生素选用[J].中华小儿外科杂志,2004,25(2):23-5.
[21]崔娆,王建峰,席红卫.小儿急性阑尾炎细菌移位及相关性的研究[J].中华小儿外科杂志,2009,30(7):451-4.
[22]郭立明,高强,孙雪荣.儿童急性腹腔感染的病原学和药敏结果分析[J].检验医学与临床,2016,13(21):3065-7.
[23]舒发,张雁涵,吴永隆,等.儿童急性阑尾炎致病菌及药物敏感谱分析[J].中华实用儿科临床杂志,2015,30(11):836-9.
[24]Lowe CF,Katz K,Mcgeer AJ,et al.Efficacy of admission screening for extended-spectrum beta-lactamase producing Enterobacteriaceae[J].PLoS One,2013,8(4):e62678.
[25]Grover N,Sahni AK,Bhattacharya S.Therapeutic challenges of ESBLS and Amp C beta-lactamase producers in a tertiary care center[J].Med J Armed Forces India,2013,69(1):4-10.
[26]Ghafourian S,Sadeghifard N,Soheili S,et al.Extended Spectrum Beta-lactamases:Definition,Classification and Epidemiology[J].Curr Issues Mol Biol,2015,17:11-21.
[27]Shashwati N,Kiran T,Dhanvijay AG.Study of extended spectrumβ-lactamase producing Enterobacteriaceae and antibiotic coresistance in a tertiary care teaching hospital[J].J Nat Sci Biol Med,2014,5(1):30-5.
[28]Nedjai S,Barguigua A,Djahmi N,et al.Prevalence and characterization of extended spectrum beta-lactamases in Klebsiella-Enterobacter-Serratia group bacteria,in Algeria[J].Med Mal Infect,2012,42(1):20-9.
[29]Paajanen H,Gronroos JM,Rautio T,et al.A prospective randomized controlled multicenter trial comparing antibiotic therapy with appendectomy in the treatment of uncomplicated acute appendicitis(APPAC trial)[J].BMC Surg,2013,13:3.
[30]Armstrong J,Merritt N,Jones S,et al.Non-operative management of early,acute appendicitis in children:is it safe and effective?[J].J Pediatr Surg,2014,49(5):782-5.
[31]Schmitt F,Clermidi P,Dorsi M,et al.Bacterial studies of complicated appendicitis over a 20-year period and their impact on empirical antibiotic treatment[J].J Pediatr Surg,2012,47(11):2055-62
[32]Obinwa O,Casidy M,Flynn J.The microbiology of bacterial peritonitis due to appendicitis in children[J].Ir J Med Sci,2014,183(4):585-91.
[33]《抗菌药物临床应用指导原则》修订工作组.抗菌药物临床应用指导原则:2015年版[M].人民卫生出版社,2015.
[34]许恒忠,张鉴.抗菌药物临床合理应用指南[M].北京:化学工业出版社,2008.
[35]Mazuski JE,Tessier JM,May AK,et al.The Surgical Infection Society Revised Guidelines on the Management of Intra-Abdominal Infection[J].Surg Infect(Larchmt),2017,18(1):1-76.
[36]Sartelli M,Chichom-Mefire A,Labricciosa FM,et al.The management of intra-abdominal infections from a global perspective:2017 WSES guidelines for management of intra-abdominal infections[J].World J Emerg Surg,2017,12:29.
[37]张少文.277例小儿急性阑尾炎围手术期抗菌药物应用分析[J].中国医院药学杂志,2010,30(21):1861-4.
[38]梅伊任,宋继红,刘燕.急性阑尾炎围手术期抗菌药物的临床应用[J].中华医院感染学杂志,2012,22(1):157-9.
[39]陈海燕,刘晓玲,曹松山,等.735例急性阑尾炎患儿围手术期抗菌药物应用分析[J].中国医院药学杂志,2015,35(18):1682-6.
[40]陈海燕,裴保方,曹松山,等.6儿童急性阑尾炎围手术期抗菌药物临床应用的干预效果[J].世界华人消化杂志,2015,23(25):4106-11.
[41]曹松山,陶兴茹,裴保方,等.儿童急性阑尾炎围术期抗菌药物合理应用的干预研究[J].中国药房,2016,27(32):4584-6.
[2]Hansson J,Khorram-Manesh A,Alwindawe A,et al.A model to select patients who may benefit from antibiotic therapy as the first line treatment of acute appendicitis at high probability[J].J Gastrointest Surg,2014,18(5):961-7.
[3]Chan KW,Lee KH,Mou JW,et al.Evidence-based adjustment of antibiotic in pediatric complicated appendicitis in the era of antibiotic resistance[J].Pediatr Surg Int,2010,26(2):157-60.
[4]Jeon HG,Ju HU,Kim GY,et al.Bacteriology and changes in antibiotic susceptibility in adults with community-acquired perforated appendicitis[J].PLoS One,2014,9(10):e111144.
[5]方莉,周敬.儿童阑尾炎的临床及病理特点分析[J].医学信息,2014,27(8):192-3.
[6]Kim YS,Kim Y,Cho OK,et al.Sonography for right lower quadrant pain[J].J Clin Ultrasound,2001,29(3):157-85.
[7]Himeno S,Yasuda S,Oida Y,et al.Ultrasonography for the diagnosis of acute appendicitis[J].Tokai J Exp Clin Med,2003,28(1):39-44.
[8]Andersson RE.Routine ultrasound and limited computed tomography for the diagnosis of acute appendicitis:a surgeon's perspective[J].World J Surg,2011,35(2):295-6.
[9]Dohan A,Soyer P.Low-dose abdominal CT for diagnosing appendicitis[J].N Engl J Med,2012,367(5):477.
[10]Al-Ajerami Y.Sensitivity and specificity of ultrasound in the diagnosis of acute appendicitis[J].East Mediterr Health J,2012,18(1):66-9.
[11]Taourel P,Baron MP,Pradel J,et al.Acute abdomen of unknown origin:impact of CT on diagnosis and management[J].Gastrointest Radiol,1992,17(4):287-91.
[12]Linton OW,Mettler FA Jr;National Council on Radiation Protection and Measurements.National conference on dose reduction in CT,with an emphasis on pediatric patients[J].AJR Am JRoentgenol,2003,181(2):321-9.
[13]Dorfman AL,Fazel R,Einstein AJ,et al.Use of medical imaging procedures with ionizing radiation in children:a population-based study[J].Arch Pediatr Adolesc Med,2011,165(5):458-64.
[14]Rezak A,Abbas HM,Ajemian M S,et al.Decreased use of computed tomography with a modified clinical scoring system in diagnosis of pediatric acute appendicitis[J].Arch Surg,2011,146(1):64-7.
[15]夏禹,黄瑛,富聪聪,等.超声与CT诊断小儿急慢性阑尾炎的对比分析[J].中国临床医学影像杂志,2014,25(11):793-6.
[16]罗新伟.儿童急性阑尾炎临床及病理特点观察[J].中国医药导报,2012,9:174-5.
[17]顾秀文,金先庆,李晓庆,等.1 179例小儿穿孔性阑尾炎的临床分析[J].重庆医学,2010,39(17):2357-8,2361.
[18]孙松,Basnet BM,郑珊,等.不同年龄小儿穿孔性阑尾炎流行病学及临床表现差异分析[J].中华小儿外科杂志,2013,34(11):814-8.
[19]舒发.小儿阑尾炎临床特点及病原学分析[D].重庆医科大学,2015.
[20]周以明,印其友,肖现民.小儿穿孔性阑尾炎致病菌群特点及抗生素选用[J].中华小儿外科杂志,2004,25(2):23-5.
[21]崔娆,王建峰,席红卫.小儿急性阑尾炎细菌移位及相关性的研究[J].中华小儿外科杂志,2009,30(7):451-4.
[22]郭立明,高强,孙雪荣.儿童急性腹腔感染的病原学和药敏结果分析[J].检验医学与临床,2016,13(21):3065-7.
[23]舒发,张雁涵,吴永隆,等.儿童急性阑尾炎致病菌及药物敏感谱分析[J].中华实用儿科临床杂志,2015,30(11):836-9.
[24]Lowe CF,Katz K,Mcgeer AJ,et al.Efficacy of admission screening for extended-spectrum beta-lactamase producing Enterobacteriaceae[J].PLoS One,2013,8(4):e62678.
[25]Grover N,Sahni AK,Bhattacharya S.Therapeutic challenges of ESBLS and Amp C beta-lactamase producers in a tertiary care center[J].Med J Armed Forces India,2013,69(1):4-10.
[26]Ghafourian S,Sadeghifard N,Soheili S,et al.Extended Spectrum Beta-lactamases:Definition,Classification and Epidemiology[J].Curr Issues Mol Biol,2015,17:11-21.
[27]Shashwati N,Kiran T,Dhanvijay AG.Study of extended spectrumβ-lactamase producing Enterobacteriaceae and antibiotic coresistance in a tertiary care teaching hospital[J].J Nat Sci Biol Med,2014,5(1):30-5.
[28]Nedjai S,Barguigua A,Djahmi N,et al.Prevalence and characterization of extended spectrum beta-lactamases in Klebsiella-Enterobacter-Serratia group bacteria,in Algeria[J].Med Mal Infect,2012,42(1):20-9.
[29]Paajanen H,Gronroos JM,Rautio T,et al.A prospective randomized controlled multicenter trial comparing antibiotic therapy with appendectomy in the treatment of uncomplicated acute appendicitis(APPAC trial)[J].BMC Surg,2013,13:3.
[30]Armstrong J,Merritt N,Jones S,et al.Non-operative management of early,acute appendicitis in children:is it safe and effective?[J].J Pediatr Surg,2014,49(5):782-5.
[31]Schmitt F,Clermidi P,Dorsi M,et al.Bacterial studies of complicated appendicitis over a 20-year period and their impact on empirical antibiotic treatment[J].J Pediatr Surg,2012,47(11):2055-62
[32]Obinwa O,Casidy M,Flynn J.The microbiology of bacterial peritonitis due to appendicitis in children[J].Ir J Med Sci,2014,183(4):585-91.
[33]《抗菌药物临床应用指导原则》修订工作组.抗菌药物临床应用指导原则:2015年版[M].人民卫生出版社,2015.
[34]许恒忠,张鉴.抗菌药物临床合理应用指南[M].北京:化学工业出版社,2008.
[35]Mazuski JE,Tessier JM,May AK,et al.The Surgical Infection Society Revised Guidelines on the Management of Intra-Abdominal Infection[J].Surg Infect(Larchmt),2017,18(1):1-76.
[36]Sartelli M,Chichom-Mefire A,Labricciosa FM,et al.The management of intra-abdominal infections from a global perspective:2017 WSES guidelines for management of intra-abdominal infections[J].World J Emerg Surg,2017,12:29.
[37]张少文.277例小儿急性阑尾炎围手术期抗菌药物应用分析[J].中国医院药学杂志,2010,30(21):1861-4.
[38]梅伊任,宋继红,刘燕.急性阑尾炎围手术期抗菌药物的临床应用[J].中华医院感染学杂志,2012,22(1):157-9.
[39]陈海燕,刘晓玲,曹松山,等.735例急性阑尾炎患儿围手术期抗菌药物应用分析[J].中国医院药学杂志,2015,35(18):1682-6.
[40]陈海燕,裴保方,曹松山,等.6儿童急性阑尾炎围手术期抗菌药物临床应用的干预效果[J].世界华人消化杂志,2015,23(25):4106-11.
[41]曹松山,陶兴茹,裴保方,等.儿童急性阑尾炎围术期抗菌药物合理应用的干预研究[J].中国药房,2016,27(32):4584-6.
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