2型糖尿病合并高尿酸血症患者脉搏波传导速度的变化

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英文篇名：Changes of Pulse Wave Velocity in Patients with Type 2 Diabetes Mellitus Combined with Hyperuricemia 作者：蔡辉耀 ; 黄惠斌 ; 姜峥嵘 ; 梁波 ; 李良毅 ; 李希圣 英文作者：CAI Huiyao;HUANG Huibin;JIANG Zhengrong;The Second Affiliated Hospital of Fujian Medical University; 关键词：2型糖尿病 ; 尿酸 ; 脉搏波传导速度 英文关键词：Type 2 diabetes mellitus;;Uric acid;;Pulse wave velocity 中文刊名：YJZY 英文刊名：Chinese and Foreign Medical Research 机构：福建医科大学附属第二医院; 出版日期：2019-05-15 出版单位：中外医学研究 年：2019 期：v.17;No.418 基金：泉州市科技局项目(项目编号:2014Z28) 语种：中文; 页：YJZY201914027 页数：2 CN：14 ISSN：23-1555/R 分类号：63-64

摘要

目的:探讨2型糖尿病患者血尿酸对脉搏波传导速度(pulse wave velocity,PWV)的影响。方法:2型糖尿病患者136例分为两组,分别为2型糖尿病组(n=72)、2型糖尿病合并高尿酸血症组(n=64),同期纳入健康人群54例为对照组,三组均行血尿酸水平检测和PWV测定。结果:2型糖尿病组、2型糖尿病合并高尿酸血症组患者的ba-PWV值均显著高于对照组,差异有统计学意义(P<0.05);2型糖尿病合并高尿酸血症组患者的ba-PWV值明显高于糖尿病组,差异有统计学意义(P<0.05)。结论:2型糖尿病患者PWV均升高,且2型糖尿病合并高尿酸血症患者较2型糖尿病患者PWV升高。高尿酸血症促使2型糖尿病患者动脉弹性降低。
        Objective:To investigate the effect of uric acid on pulse wave velocity(PWV) in patients with type 2 diabetes mellitus.Method:136 patients with type 2 diabetes mellitus were divided into two groups,included the type 2 diabetes mellitus group(n=72),the type 2 diabetes mellitus group combined with hyperuricemia group(n=64) and the control group with 54 healthy subjects in the same period.Blood uric acid levels and PWV were measured in all three groups.Result:The ba-PWV of the type 2 diabetes mellitus group and the type 2 diabetes mellitus group combined with hyperuricemia were significantly higher than those of the control group(P<0.05).The ba-PWV of the type 2 diabetes mellitus combined with hyperuricemia group was significantly higher than that of the type 2 diabetes mellitus group,and the difference was statistically significant(P<0.05).Conclusion:PWV is increased in patients with type 2 diabetes mellitus and increased in patients with type 2 diabetes mellitus combined with hyperuricemia compared with patients with type 2 diabetes mellitus.Hyperuricemia leads to decreased arterial elasticity in patients with type 2 diabetes mellitus.

引文

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