中药抗流感病毒活性及作用机制研究新进展
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摘要
流行性感冒(流感)是由流感病毒引起的急性呼吸道传染病,具有发病率高、流行广泛和病毒变异性强等特点。中药防治流感具有疗效显著、毒副作用较小、易于普及、价格低廉等优点。许多学者以中药抗流感病毒实验研究为平台,阐明了中药在抗流感病毒中起到的关键作用及其作用机制。查阅近几年相关文献,对中药(主要是单味中药和中药复方)的抗流感活性及作用机制研究进行综述,以期为抗流感病毒研究提供一定的思路和理论依据。
Pandemic influenza is an acute respiratory infectious disease caused by influenza virus infection, which has the features of high incidence, widespread prevalence, and strong variability. For the prevention and treatment of influenza, Chinese materia medica(CMM) has obvious effects, relatively less toxic side effects, and it is popular and cheap, etc. Many scholars demonstrated the critical roles and mechanisms of CMM using the experiments of CMM against influenza virus. With investigating related literatures in recent years, this article summarizes the anti-influenza activities and mechanisms of actions of CMM, mainly the single herb and compound prescription, in order to provide idea and theoretical basis for future anti-influenza research.
Pandemic influenza is an acute respiratory infectious disease caused by influenza virus infection, which has the features of high incidence, widespread prevalence, and strong variability. For the prevention and treatment of influenza, Chinese materia medica(CMM) has obvious effects, relatively less toxic side effects, and it is popular and cheap, etc. Many scholars demonstrated the critical roles and mechanisms of CMM using the experiments of CMM against influenza virus. With investigating related literatures in recent years, this article summarizes the anti-influenza activities and mechanisms of actions of CMM, mainly the single herb and compound prescription, in order to provide idea and theoretical basis for future anti-influenza research.
引文
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[6]Wan Q,Wang H,Han X,et al.Baicalin inhibits TLR7/MYD88 signaling pathway activation to suppress lung inflammation in mice infected with influenza A virus[J].Biomed Rep,2014,2(3):437-441.
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[11]Li Z,Li L,Zhou H,et al.Radix Isatidis polysaccharides inhibit influenza a virus and influenza A virus-induced inflammation via suppression of host TLR3 signaling in vitro[J].Molecules,2017,22(1):1-11.
[12]Xiao P,Ye W,Chen J,et al.Antiviral activities against influenza virus(FM1)of bioactive fractions and representative compounds extracted from Banlangen(Radix Isatidis)[J].J Tradit Chin Med,2016,36(3):369-376.
[13]Cai W,Li Y,Chen S,et al.14-Deoxy-11,12-dehydroandrographolide exerts anti-influenza A virus activity and inhibits replication of H5N1 virus by restraining nuclear export of viral ribonucleoprotein complexes[J].Antiviral Res,2015,118:82-92.
[14]Cai W,Chen S,Li Y,et al.14-Deoxy-11,12-didehydroandrographolide attenuates excessive inflammatory responses and protects mice lethally challenged with highly pathogenic A(H5N1)influenza viruses[J].Antiviral Res,2016,133:95-105.
[15]Ding Y,Chen L,Wu W,et al.Andrographolide inhibits influenza A virus-induced inflammation in a murine model through NF-κB and JAK-STAT signaling pathway[J].Microbes Infect,2017,19(12):605-615.
[16]Yuan L,Zhang C,Sun H,et al.The semi-synthesis of novel andrographolide analogues and anti-influenza virus activity evaluation of their derivatives[J].Bioorg MedChem Lett,2016,26(3):769-773.
[17]夏晓玲,孙强明,王晓丹,等.云南特色中药臭灵丹体外抗甲型H1N1流感病毒的实验研究[J].中国中药杂志,2015,40(18):3687-3692.
[18]黄婉怡,王玉涛,王新华.基于民族用药经验研究臭灵丹挥发油体内外抗流感的药效学作用[J].四川中医,2016,34(3):59-62.
[19]Guan W,Li J,Chen Q,et al.Pterodontic acid isolated from Laggera pterodonta inhibits viral replication and inflammation induced by influenza A virus[J].Molecules,2017,22(10):1-14.
[20]王变利,高燕,赵秀香.金银花水提物体外抗病毒实验研究[J].辽宁中医杂志,2015,42(8):1495-1497.
[21]王姣娇,李海波,鲍欣欣,等.金银花不同组分对甲型流感病毒神经氨酸酶抑制作用研究[J].中国卫生标准管理,2017,8(22):98-100.
[22]Zhou Z,Li X,Liu J,et al.Honeysuckle-encoded atypical micro RNA2911 directly targets influenza A viruses[J].Cell Res,2015,25(1):39-49.
[23]贾伟,毛淑敏,张盼盼,等.金银花多糖体内抗病毒作用研究[J].辽宁中医药大学学报,2018,20(6):25-27.
[24]邱玲玲,肖莹,支星,等.Box-Behnken响应曲面法筛选金银花中抗流感病毒活性成分研究[J].中国现代中药,2016,18(11):1454-1457.
[25]姚干,王允,刘毅,等.黄芩总黄酮和栀子总环烯醚萜对含药小鼠血清体外抗病毒作用[J].中成药,2014,36(4):698-701.
[26]刘晓婷,顾立刚,邓东沅,等.黄芩苷和木犀草苷在体外对流感病毒H1N1感染A549细胞中NF-κB信号通路的调控作用[J].中华中医药杂志,2016,31(5):1937-1941.
[27]郭姗姗,包蕾,崔晓兰.黄芩苷对宿主因子PACT干扰后流感病毒RNA聚合酶活性的影响[J].中国药物警戒,2016,13(3):129-131.
[28]Peng P,Ke Z,Sizhi W,et al.Baicalin downregulates RLRs signaling pathway to control influenza A virus infection and improve the prognosis[J].Evid Based Compl Alternat Med,2018,2018:1-10.
[29]刘晓婷,张沂,顾立刚,等.流感病毒H1N1感染A549细胞诱导凋亡及黄芩苷干预作用的研究[J].中国药理学通报,2015,31(7):936-939.
[30]吴彤,牛姝力,白梅.黄芩苷对流感病毒A/PR/8/34(H1N1)感染小鼠内质网应激反应的干预作用[J].中国病原生物学杂志,2017,12(6):553-556.
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