金银花的药理作用及其在兽医临床中的应用
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摘要
金银花是忍冬科植物忍冬的干燥花蕾或初开的花,性味甘寒,具有清热解毒、疏散风热的功效。论文对金银花及其提取物的抗炎、抗菌、抗病毒、免疫调节、降血脂、降血糖等药理作用及在兽医临床中的应用进行了综述。当前,随着公众对食品安全的重视,社会上就动物产品安全性(兽药残留、抗生素滥用等)广泛关注。而通过对金银花及其提取物的深入研究,揭示了其更多潜在的药理作用。在此背景下,就动物生产过程中需关注的一些问题及金银花潜在的应用价值,提出了新的看法,以期为后续的研究和应用提供参考。
Honeysuckle is the dry flower bud or early blossoms of Lonicera japonica Thunb,which has the effect of clearing away heat and toxic materials and dispelling wind and heat.The anti-inflammatory,antibacterial,anti-viral effects,immune regulation,lower blood lipid and blood sugar and other pharmacological functions of honeysuckle and its extracts were reviewed in this paper.At present,with the public's emphasis on food safety,the society has conducted extensive discussions on the safety of animal products(veterinary drug residues,antibiotic abuse,etc.).And through the deep study of honeysuckle and its extract,it reveals more potential pharmacological effects.The paper put forward a new view on some problems that need to pay attention to the process of animal production and the potential application value of honeysuckle,so as to provide references for future research and application.
Honeysuckle is the dry flower bud or early blossoms of Lonicera japonica Thunb,which has the effect of clearing away heat and toxic materials and dispelling wind and heat.The anti-inflammatory,antibacterial,anti-viral effects,immune regulation,lower blood lipid and blood sugar and other pharmacological functions of honeysuckle and its extracts were reviewed in this paper.At present,with the public's emphasis on food safety,the society has conducted extensive discussions on the safety of animal products(veterinary drug residues,antibiotic abuse,etc.).And through the deep study of honeysuckle and its extract,it reveals more potential pharmacological effects.The paper put forward a new view on some problems that need to pay attention to the process of animal production and the potential application value of honeysuckle,so as to provide references for future research and application.
引文
[1]国家药典委员会.中华人民共和国药典(2015年版一部)[M].北京:中国医药科技出版社,2015.
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[3]戴江瑞.中药金银花的药用成分及临床药理分析[J].临床医药文献杂志,2017,58(4):11352-11353.
[4]夏伟,余永亮,杨红旗,等.金银花化学成分及药理作用研究进展[J],安徽农业科学,2017,45(33):126-127.
[5]孟晓丹.分析中药金银花的药用成分与药理作用[J].中国现代药物应用,2016,10(13):276-277.
[6]崔晓燕.金银花提取物的抗炎免疫作用研究[J].中国药业,2011,23(20):8-9.
[7]Yoo H J,Kang H J,Song Y S,et al.Anti-angiogenic,antinociceptive and anti-inflammatory activities of Lonicera japonica extract[J].J Pharm Pharmacol,2008,60(6):779-786.
[8]Kang O H,Choi J G,Lee J H,et al.Luteolin isolated from the flowers of Lonicera japonica suppresses inflammatory mediator release by blocking NF-κB and MAPKs activation pathways in HMC-1cells[J].Mol,2010,15(1):385-398.
[9]王林清,崔保安,张红英,等.中药金银花提取物抗炎作用研究[J].中国畜牧兽医,2008,35(8):82-84.
[10]Jing Y,Li Y H,Zhou X R,et al.Two thymol derivatives from the flower buds of Lonicera japonica and their antibacterial activity[J].Nat Prod Res,2017,18(32):2238-2243.
[11]阮之阳,王兆梅,黎嘉嘉,等.金银花挥发油及残渣浸膏的抗菌活性研究[J].现代食品科技,2017,33(10):77-82.
[12]贺常亮,张小艺,杨航,等.金银花提取物对金黄色葡萄球菌的抗菌作用研究[J].贵州畜牧兽医,2013,37(4):11-14.
[13]阮武营,张俊婷,黄宗梅,等.金银花提取物的体外抑菌试验[J].河南畜牧兽医,2016,37(7):12-13.
[14]张召兴,李蕴玉,常超越,等.中药对鸡致病性大肠埃希菌的体外抑菌试验[J].动物医学进展,2017,38(3):63-67.
[15]Yang X Y,Liu Y L,Hou A J,et al.Systematic review for geoauthentic Lonicerae japonicae flos[J].Front Med,2017,11(2):203-213.
[16]崔燕,徐红梅.金银花的药理作用研究综述[J].科学技术创新,2018(2):20-21.
[17]陈峰,江玉婷,于云飞,等.金银花提取物体外抗猪繁殖与呼吸综合征病毒研究[J].动物医学进展,2012,33(2):41-45.
[18]王林清,崔保安,张红英.金银花、山银花黄酮类提取物体外抗伪狂犬病病毒作用研究[J].中国畜牧兽医,2011,38(3):183-188.
[19]王国霞,邹海棠,梅春升,等.黄芪、金银花提取物体外抗禽流感病毒的试验研究[J].中兽医学杂志,2005(3):4-6.
[20]王华,迟琼,熊石龙,等.金银花提取物对LPS致ARDS大鼠肺炎症影响的研究[J].广东药科大学学报,2017,33(3):379-382.
[21]靳二辉,陈耀星,周金星,等.黄芪、枸杞、金银花等中草药复方制剂对肉鸡免疫器官发育及免疫功能的影响[J].畜牧兽医学报,2017,48(6):1128-1139.
[22]李立,杜雅薇,寇爽,等.金银花、连翘对甲型H1N1流感免疫调节通路影响的生物信息学分析[J].中国实验方剂学杂志,2017,23(10):201-204.
[23]徐佳佳,蒙秋华,蒙雪芳,等.25种广西道地药材对α-淀粉酶的抑制作用[J].时珍国医国药,2017,28(5):1075-1076.
[24]Liu Q,Liu S N,Gao L H,et al.Anti-diabetic effects and mechanisms of action of a Chinese herbal medicine preparation JQRin vitro and in diabetic KKAy mice[J].Acta Pharm Sin B,2017,7(4):461-469.
[25]Zhao X M,Wang D Y,Qin L J,et al,Comparative investigation for hypoglycemic effects of polysaccharides from four substitutes of Lonicera japonicain Chinese medicine[J].Int J Biol Macromol,2018,109:12-20.
[26]李卫东,耗霄波.研究分析金银花的药用成分及中药药理作用[J].中国实用医药,2016,24(11):269-270.
[27]Park S,Kang S,Da S K,et al.Agrimonia pilosa Ledeb,Cinnamomum cassia Blume,and Lonicera japonica Thunb.protect against cognitive dysfunction and energy and glucose dysregulation by reducing neuroinflammation and hippocampal insulin resistance inβ-amyloid-infused rats[J].Nutr Neurosci,2017,20(2):77-88.
[28]Su D Y,Li S,Zhang W,et al.Structural elucidation of a polysaccharide from Lonicera japonica flowers,and its neuroprotective effect on cerebral ischemia-reperfusion injury in rat[J].Int J Biol Macromol,2017,102(1):413
[29]Han X L,Li J D,Wang W L,et al.Sweroside eradicated leukemia cells and attenuated pathogenic processes in mice by inducing apoptosis[J].Biomed Pharmacother,2017,95:477-486.
[30]符运斌,黄涛,瞿明仁,等.金银花提取物对热应激肉牛血清激素及抗氧化指标的影响[J].动物营养学报,2016,28(3):926-931.
[2]任俊洁,姜雪.金银花化学成分和药理作用研究进展[J].化学时刊,2017,31(6):20-23.
[3]戴江瑞.中药金银花的药用成分及临床药理分析[J].临床医药文献杂志,2017,58(4):11352-11353.
[4]夏伟,余永亮,杨红旗,等.金银花化学成分及药理作用研究进展[J],安徽农业科学,2017,45(33):126-127.
[5]孟晓丹.分析中药金银花的药用成分与药理作用[J].中国现代药物应用,2016,10(13):276-277.
[6]崔晓燕.金银花提取物的抗炎免疫作用研究[J].中国药业,2011,23(20):8-9.
[7]Yoo H J,Kang H J,Song Y S,et al.Anti-angiogenic,antinociceptive and anti-inflammatory activities of Lonicera japonica extract[J].J Pharm Pharmacol,2008,60(6):779-786.
[8]Kang O H,Choi J G,Lee J H,et al.Luteolin isolated from the flowers of Lonicera japonica suppresses inflammatory mediator release by blocking NF-κB and MAPKs activation pathways in HMC-1cells[J].Mol,2010,15(1):385-398.
[9]王林清,崔保安,张红英,等.中药金银花提取物抗炎作用研究[J].中国畜牧兽医,2008,35(8):82-84.
[10]Jing Y,Li Y H,Zhou X R,et al.Two thymol derivatives from the flower buds of Lonicera japonica and their antibacterial activity[J].Nat Prod Res,2017,18(32):2238-2243.
[11]阮之阳,王兆梅,黎嘉嘉,等.金银花挥发油及残渣浸膏的抗菌活性研究[J].现代食品科技,2017,33(10):77-82.
[12]贺常亮,张小艺,杨航,等.金银花提取物对金黄色葡萄球菌的抗菌作用研究[J].贵州畜牧兽医,2013,37(4):11-14.
[13]阮武营,张俊婷,黄宗梅,等.金银花提取物的体外抑菌试验[J].河南畜牧兽医,2016,37(7):12-13.
[14]张召兴,李蕴玉,常超越,等.中药对鸡致病性大肠埃希菌的体外抑菌试验[J].动物医学进展,2017,38(3):63-67.
[15]Yang X Y,Liu Y L,Hou A J,et al.Systematic review for geoauthentic Lonicerae japonicae flos[J].Front Med,2017,11(2):203-213.
[16]崔燕,徐红梅.金银花的药理作用研究综述[J].科学技术创新,2018(2):20-21.
[17]陈峰,江玉婷,于云飞,等.金银花提取物体外抗猪繁殖与呼吸综合征病毒研究[J].动物医学进展,2012,33(2):41-45.
[18]王林清,崔保安,张红英.金银花、山银花黄酮类提取物体外抗伪狂犬病病毒作用研究[J].中国畜牧兽医,2011,38(3):183-188.
[19]王国霞,邹海棠,梅春升,等.黄芪、金银花提取物体外抗禽流感病毒的试验研究[J].中兽医学杂志,2005(3):4-6.
[20]王华,迟琼,熊石龙,等.金银花提取物对LPS致ARDS大鼠肺炎症影响的研究[J].广东药科大学学报,2017,33(3):379-382.
[21]靳二辉,陈耀星,周金星,等.黄芪、枸杞、金银花等中草药复方制剂对肉鸡免疫器官发育及免疫功能的影响[J].畜牧兽医学报,2017,48(6):1128-1139.
[22]李立,杜雅薇,寇爽,等.金银花、连翘对甲型H1N1流感免疫调节通路影响的生物信息学分析[J].中国实验方剂学杂志,2017,23(10):201-204.
[23]徐佳佳,蒙秋华,蒙雪芳,等.25种广西道地药材对α-淀粉酶的抑制作用[J].时珍国医国药,2017,28(5):1075-1076.
[24]Liu Q,Liu S N,Gao L H,et al.Anti-diabetic effects and mechanisms of action of a Chinese herbal medicine preparation JQRin vitro and in diabetic KKAy mice[J].Acta Pharm Sin B,2017,7(4):461-469.
[25]Zhao X M,Wang D Y,Qin L J,et al,Comparative investigation for hypoglycemic effects of polysaccharides from four substitutes of Lonicera japonicain Chinese medicine[J].Int J Biol Macromol,2018,109:12-20.
[26]李卫东,耗霄波.研究分析金银花的药用成分及中药药理作用[J].中国实用医药,2016,24(11):269-270.
[27]Park S,Kang S,Da S K,et al.Agrimonia pilosa Ledeb,Cinnamomum cassia Blume,and Lonicera japonica Thunb.protect against cognitive dysfunction and energy and glucose dysregulation by reducing neuroinflammation and hippocampal insulin resistance inβ-amyloid-infused rats[J].Nutr Neurosci,2017,20(2):77-88.
[28]Su D Y,Li S,Zhang W,et al.Structural elucidation of a polysaccharide from Lonicera japonica flowers,and its neuroprotective effect on cerebral ischemia-reperfusion injury in rat[J].Int J Biol Macromol,2017,102(1):413
[29]Han X L,Li J D,Wang W L,et al.Sweroside eradicated leukemia cells and attenuated pathogenic processes in mice by inducing apoptosis[J].Biomed Pharmacother,2017,95:477-486.
[30]符运斌,黄涛,瞿明仁,等.金银花提取物对热应激肉牛血清激素及抗氧化指标的影响[J].动物营养学报,2016,28(3):926-931.
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