纳米铁氧化物磁热疗相关机制研究进展
|
摘要
热疗作为继手术、放疗和化疗后的肿瘤治疗的重要方法之一,自其诞生之初便受到研究人员和产业部门的关注.磁热疗目前已经应用到前列腺癌、脑部肿瘤等临床实验或治疗中,并取得较好的疗效.本文主要介绍基于磁性纳米颗粒的磁热疗产热物理机制与影响因素,以及磁热的亚细胞水平生物学效应.
Hyperthermia is a major method for cancer treatment besides surgery, radiotherapy and chemotherapy. It has been increasingly applied to prostate cancer, brain tumors, etc. in preclinical and/or clinical.In this review, we discuss the physical mechanism, influencing factors of magnetothermal effect, and biologic effects of current magnetic hyperthermia treatment using iron oxides nanoparticles.
Hyperthermia is a major method for cancer treatment besides surgery, radiotherapy and chemotherapy. It has been increasingly applied to prostate cancer, brain tumors, etc. in preclinical and/or clinical.In this review, we discuss the physical mechanism, influencing factors of magnetothermal effect, and biologic effects of current magnetic hyperthermia treatment using iron oxides nanoparticles.
引文
[1]陈万青,孙可欣,郑荣寿,等.2014年中国分地区恶性肿瘤发病和死亡分析.中国肿瘤,2018,27(1):1-14Chen W Q,Sun K X,Zheng R S,et al.China Cancer,2018,27(1):1-14
[2]Gilchrist R K,Medal R,Shorey W D,et al.Selective inductive heating of lymph nodes.Ann Surg,1957,146(4):596-606
[3]Roussakow S.The history of hyperthermia rise and decline.Conference Papers in Medicine,2013,2013:1-40
[4]Crile G.The effects of heat and radiation on cancers implanted on the feet of mice.Cancer Res,1963,23(3):372-380
[5]王宇瀛,赵凌云,王晓文,等.磁感应热疗治疗肿瘤研究进展和临床试验.科技导报,2010,28(20):101-107Wang Y Y,Zhao L Y,Wang X W,et al.Science&Technology Review,2010,28(20):101-107
[6]谢俊,陈玲,严长志,等.肿瘤靶向热疗用磁性纳米材料.中国材料进展,2016,35(08):561-568Xie J,Chen L,Yan C Z,et al.Meterials China,2016,35(08):561-568
[7]Hedayatnasab Z,Abnisa F,Daud W M a W.Review on magnetic nanoparticles for magnetic nanofluid hyperthermia application.Mater Design,2017,123:174-196
[8]Laurent S,Dutz S,Hafeli U O,et al.Magnetic fluid hyperthermia:focus on superparamagnetic iron oxide nanoparticles.Adv Colloid Interfac,2011,166(1-2):8-23
[9]Rosensweig R E.Heating magnetic fluid with alternating magnetic field.Journal of Magnetism and Magnetic Materials,2002,252(1-3):370-374
[10]Dunitz J D,Orgel L E.Electronic properties of transition-metal oxides-II.Journal of Physics and Chemistry of Solids,1957,3(3-4):318-323
[11]Friák M,Schindlmayr A,Scheffler M.Ab initiostudy of the halfmetal to metal transition in strained magnetite.New Journal of Physics,2007,9(1):5-20
[12]Pool V L,Klem M T,Holroyd J,et al.Site determination of Zn doping in protein encapsulated ZnxFe3-XO4nanoparticles.Journal ofApplied Physics,2009,105(7):07B515
[13]Pool V,Klem M,Jolley C,et al.Site determination and magnetism of Mn doping in protein encapsulated iron oxide nanoparticles.Journal ofApplied Physics,2010,107(9):09b517
[14]Yoon T J,Lee H,Shao H,et al.Highly magnetic core-shell nanoparticles with a unique magnetization mechanism.Angew Chem Int Ed Engl,2011,50(20):4663-4666
[15]Zhou P,Zhao H,Wang Q,et al.Photoacoustic-enabled selfguidance in magnetic-hyperthermia Fe@Fe3O4nanoparticles for theranostics in vivo.Adv Healthc Mater,2018,7(9):e1701201
[16]Wang J,Zhao H,Zhou Z,et al.MR/SPECT imaging guided photothermal therapy of tumor-targeting Fe@Fe3O4nanoparticles in vivo with low mononuclear phagocyte uptake.ACS Appl Mater Interfaces,2016,8(31):19872-19882
[17]Garaio E,Collantes J M,Garcia J A,et al.A wide-frequency range AC magnetometer to measure the specific absorption rate in nanoparticles for magnetic hyperthermia.Journal of Magnetism and Magnetic Materials,2014,368:432-437
[18]Sabale S,Jadhav V,Khot V,et al.Superparamagnetic MFe2O4(M=Ni,Co,Zn,Mn)nanoparticles:synthesis,characterization,induction heating and cell viability studies for cancer hyperthermia applications.J Mater Sci-Mater M,2015,26(3):127
[19]De La Presa P,Luengo Y,Multigner M,et al.Study of heating efficiency as a function of concentration,size,and applied field inγ-Fe2O3nanoparticles.The Journal of Physical Chemistry C,2012,116(48):25602-25610
[20]Fortin J P,Wilhelm C,Servais J,et al.Size-sorted anionic iron oxide nanomagnets as colloidal mediators for magnetic hyperthermia.JAm Chem Soc,2007,129(9):2628-2635
[21]Ma M,Wu Y,Zhou H,et al.Size dependence of specific power absorption of Fe3O4particles in AC magnetic field.Journal of Magnetism and Magnetic Materials,2004,268(1-2):33-39
[22]Kallumadil M,Tada M,Nakagawa T,et al.Suitability of commercial colloids for magnetic hyperthermia.Journal of Magnetism and Magnetic Materials,2009,321(10):1509-1513
[23]Deatsch A E,Evans B A.Heating efficiency in magnetic nanoparticle hyperthermia.Journal of Magnetism and Magnetic Materials,2014,354:163-172
[24]Cobianchi M,Guerrini A,Avolio M,et al.Experimental determination of the frequency and field dependence of specific loss power in magnetic fluid hyperthermia.Journal of Magnetism and Magnetic Materials,2017,444:154-160
[25]Carrey J,Mehdaoui B,Respaud M.Simple models for dynamic hysteresis loop calculations of magnetic single-domain nanoparticles:application to magnetic hyperthermia optimization.Journal ofApplied Physics,2011,109(8):083921
[26]石永进,虞积仁,岑溪南,等.热疗促进HSP70表达对免疫效应细胞杀伤肿瘤的影响.北京大学学报(医学版),2005,37(2):175-178Shi Y J,Yu J R,Cen X N,et al.Journal of Peking University.Health Sciences,2005,37(02):175-178
[27]齐宝宁,王小平,王希楠,等.热疗对免疫细胞的影响及机制.现代肿瘤医学,2018,26(16):2635-2639Qi B N,Wang X P,Wang X N,et al.Modern Oncology,2018,26(16):2635-2639
[28]Kobayashi T,Kakimi K,Nakayama E,et al.Antitumor immunity by magnetic nanoparticle-mediated hyperthermia.Nanomedicine(Lond),2014,9(11):1715-1726
[29]Lepock J R.Involvement of membranes in cellular responses to hyperthermia.Radiat Res,1982,92(3):433-438
[30]Calatayud M P,Soler E,Torres T E,et al.Cell damage produced by magnetic fluid hyperthermia on microglial BV2 cells.Sci Rep,2017,7(1):8627
[31]Prasad N K,Rathinasamy K,Panda D,et al.Mechanism of cell death induced by magnetic hyperthermia with nanoparticles of gamma-MnxFe2-xO3synthesized by a single step process.J Mater Chem,2007,17(48):5042-5051
[32]Creixell M,Bohorquez A C,Torres-Lugo M,et al.EGFR-targeted magnetic nanoparticle heaters kill cancer cells without a perceptible temperature rise.ACS Nano,2011,5(9):7124-7129
[33]Domenech M,Marrero-Berrios I,Torres-Lugo M,et al.Lysosomal membrane permeabilization by targeted magnetic nanoparticles in alternating magnetic fields.ACS Nano,2013,7(6):5091-5101
[34]Wang Z,Cai F,Chen X,et al.The role of mitochondria-derived reactive oxygen species in hyperthermia-induced platelet apoptosis.Plos One,2013,8(9):e75044
[35]Hilger I,Rapp A,Greulich K O,et al.Assessment of DNA damage in target tumor cells after thermoablation in mice.Radiology,2005,237(2):500-506
[36]Cao C,Wang X,Cai Y,et al.Targeted in vivo imaging of microscopic tumors with ferritin-based nanoprobes across biological barriers.Advanced Materials,2014,26(16):2566-2571
[37]Gogoi M,Jaiswal M K,Sarma H D,et al.Biocompatibility and therapeutic evaluation of magnetic liposomes designed for selfcontrolled cancer hyperthermia and chemotherapy.Integr Biol(Camb),2017,9(6):555-565
[2]Gilchrist R K,Medal R,Shorey W D,et al.Selective inductive heating of lymph nodes.Ann Surg,1957,146(4):596-606
[3]Roussakow S.The history of hyperthermia rise and decline.Conference Papers in Medicine,2013,2013:1-40
[4]Crile G.The effects of heat and radiation on cancers implanted on the feet of mice.Cancer Res,1963,23(3):372-380
[5]王宇瀛,赵凌云,王晓文,等.磁感应热疗治疗肿瘤研究进展和临床试验.科技导报,2010,28(20):101-107Wang Y Y,Zhao L Y,Wang X W,et al.Science&Technology Review,2010,28(20):101-107
[6]谢俊,陈玲,严长志,等.肿瘤靶向热疗用磁性纳米材料.中国材料进展,2016,35(08):561-568Xie J,Chen L,Yan C Z,et al.Meterials China,2016,35(08):561-568
[7]Hedayatnasab Z,Abnisa F,Daud W M a W.Review on magnetic nanoparticles for magnetic nanofluid hyperthermia application.Mater Design,2017,123:174-196
[8]Laurent S,Dutz S,Hafeli U O,et al.Magnetic fluid hyperthermia:focus on superparamagnetic iron oxide nanoparticles.Adv Colloid Interfac,2011,166(1-2):8-23
[9]Rosensweig R E.Heating magnetic fluid with alternating magnetic field.Journal of Magnetism and Magnetic Materials,2002,252(1-3):370-374
[10]Dunitz J D,Orgel L E.Electronic properties of transition-metal oxides-II.Journal of Physics and Chemistry of Solids,1957,3(3-4):318-323
[11]Friák M,Schindlmayr A,Scheffler M.Ab initiostudy of the halfmetal to metal transition in strained magnetite.New Journal of Physics,2007,9(1):5-20
[12]Pool V L,Klem M T,Holroyd J,et al.Site determination of Zn doping in protein encapsulated ZnxFe3-XO4nanoparticles.Journal ofApplied Physics,2009,105(7):07B515
[13]Pool V,Klem M,Jolley C,et al.Site determination and magnetism of Mn doping in protein encapsulated iron oxide nanoparticles.Journal ofApplied Physics,2010,107(9):09b517
[14]Yoon T J,Lee H,Shao H,et al.Highly magnetic core-shell nanoparticles with a unique magnetization mechanism.Angew Chem Int Ed Engl,2011,50(20):4663-4666
[15]Zhou P,Zhao H,Wang Q,et al.Photoacoustic-enabled selfguidance in magnetic-hyperthermia Fe@Fe3O4nanoparticles for theranostics in vivo.Adv Healthc Mater,2018,7(9):e1701201
[16]Wang J,Zhao H,Zhou Z,et al.MR/SPECT imaging guided photothermal therapy of tumor-targeting Fe@Fe3O4nanoparticles in vivo with low mononuclear phagocyte uptake.ACS Appl Mater Interfaces,2016,8(31):19872-19882
[17]Garaio E,Collantes J M,Garcia J A,et al.A wide-frequency range AC magnetometer to measure the specific absorption rate in nanoparticles for magnetic hyperthermia.Journal of Magnetism and Magnetic Materials,2014,368:432-437
[18]Sabale S,Jadhav V,Khot V,et al.Superparamagnetic MFe2O4(M=Ni,Co,Zn,Mn)nanoparticles:synthesis,characterization,induction heating and cell viability studies for cancer hyperthermia applications.J Mater Sci-Mater M,2015,26(3):127
[19]De La Presa P,Luengo Y,Multigner M,et al.Study of heating efficiency as a function of concentration,size,and applied field inγ-Fe2O3nanoparticles.The Journal of Physical Chemistry C,2012,116(48):25602-25610
[20]Fortin J P,Wilhelm C,Servais J,et al.Size-sorted anionic iron oxide nanomagnets as colloidal mediators for magnetic hyperthermia.JAm Chem Soc,2007,129(9):2628-2635
[21]Ma M,Wu Y,Zhou H,et al.Size dependence of specific power absorption of Fe3O4particles in AC magnetic field.Journal of Magnetism and Magnetic Materials,2004,268(1-2):33-39
[22]Kallumadil M,Tada M,Nakagawa T,et al.Suitability of commercial colloids for magnetic hyperthermia.Journal of Magnetism and Magnetic Materials,2009,321(10):1509-1513
[23]Deatsch A E,Evans B A.Heating efficiency in magnetic nanoparticle hyperthermia.Journal of Magnetism and Magnetic Materials,2014,354:163-172
[24]Cobianchi M,Guerrini A,Avolio M,et al.Experimental determination of the frequency and field dependence of specific loss power in magnetic fluid hyperthermia.Journal of Magnetism and Magnetic Materials,2017,444:154-160
[25]Carrey J,Mehdaoui B,Respaud M.Simple models for dynamic hysteresis loop calculations of magnetic single-domain nanoparticles:application to magnetic hyperthermia optimization.Journal ofApplied Physics,2011,109(8):083921
[26]石永进,虞积仁,岑溪南,等.热疗促进HSP70表达对免疫效应细胞杀伤肿瘤的影响.北京大学学报(医学版),2005,37(2):175-178Shi Y J,Yu J R,Cen X N,et al.Journal of Peking University.Health Sciences,2005,37(02):175-178
[27]齐宝宁,王小平,王希楠,等.热疗对免疫细胞的影响及机制.现代肿瘤医学,2018,26(16):2635-2639Qi B N,Wang X P,Wang X N,et al.Modern Oncology,2018,26(16):2635-2639
[28]Kobayashi T,Kakimi K,Nakayama E,et al.Antitumor immunity by magnetic nanoparticle-mediated hyperthermia.Nanomedicine(Lond),2014,9(11):1715-1726
[29]Lepock J R.Involvement of membranes in cellular responses to hyperthermia.Radiat Res,1982,92(3):433-438
[30]Calatayud M P,Soler E,Torres T E,et al.Cell damage produced by magnetic fluid hyperthermia on microglial BV2 cells.Sci Rep,2017,7(1):8627
[31]Prasad N K,Rathinasamy K,Panda D,et al.Mechanism of cell death induced by magnetic hyperthermia with nanoparticles of gamma-MnxFe2-xO3synthesized by a single step process.J Mater Chem,2007,17(48):5042-5051
[32]Creixell M,Bohorquez A C,Torres-Lugo M,et al.EGFR-targeted magnetic nanoparticle heaters kill cancer cells without a perceptible temperature rise.ACS Nano,2011,5(9):7124-7129
[33]Domenech M,Marrero-Berrios I,Torres-Lugo M,et al.Lysosomal membrane permeabilization by targeted magnetic nanoparticles in alternating magnetic fields.ACS Nano,2013,7(6):5091-5101
[34]Wang Z,Cai F,Chen X,et al.The role of mitochondria-derived reactive oxygen species in hyperthermia-induced platelet apoptosis.Plos One,2013,8(9):e75044
[35]Hilger I,Rapp A,Greulich K O,et al.Assessment of DNA damage in target tumor cells after thermoablation in mice.Radiology,2005,237(2):500-506
[36]Cao C,Wang X,Cai Y,et al.Targeted in vivo imaging of microscopic tumors with ferritin-based nanoprobes across biological barriers.Advanced Materials,2014,26(16):2566-2571
[37]Gogoi M,Jaiswal M K,Sarma H D,et al.Biocompatibility and therapeutic evaluation of magnetic liposomes designed for selfcontrolled cancer hyperthermia and chemotherapy.Integr Biol(Camb),2017,9(6):555-565