基于因子分析的412例寻常型银屑病中医证候研究
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摘要
目的探讨应用因子分析的寻常型银屑病中医临床证候要素分布,为寻常型银屑病证候分布的数据挖掘及辨证论治提供参考依据。方法通过412例寻常型银屑病患者症状、舌象、脉象等四诊信息的采集,建立相关数据库,运用因子分析数据挖掘方法进行数据处理和分析,提取寻常型银屑病的四诊变量的公因子,明确各证候要素与四诊信息的对应关系。寻找寻常型银屑病中医证候的分布规律,客观再现寻常型银屑病中医证候的本质。结果因子分析结果得出4个公因子,因子1和2的出现率最高,其包括的中医证候为血热证和湿热证;本虚证的因子中以阴虚血燥为主的因子3的出现率最高,最低出现率的因子4为血瘀证。结论寻常型银屑病进行期以血热证和湿热证发生率最高,而静止期及消退期以阴虚血燥证和瘀血证最为多见,提示血热和湿热是寻常型银屑病的重要病机。
Objective By using the factor analysis to explore the conformity traditional Chinese medicine(TCM) syndrome factors of psoriasis vulgaris clinical distribution could be provided as the evidence of data mining in TCM. Methods The clinical symptoms and signs such as tongue and pulse of the 412 patients were recorded by using questionnaire responses. By the approach of factor analysis,the common factors which dominated the variables of four diagnosis for psoriasis vulgaris were extracted,analyzed and interpreted. Results Total four common factors were included,with the highest occurrence rate of factor 2. Factor 2 represented the syndrome of blood-heat and dampness-heat. Of the deficiency syndrome,the incidence rate of syndrome of Yin deficiency with blood-dryness represented by factor 3 was the highest. The factor 4 was blood stasis with lowest rate. Conclusion The dampness-heat syndrome and the blood heat syndrome are the most common of the excessive syndromes which the two kinds of syndromes are the key pathogenesis in progressive stage. Of the deficiency syndrome,the incidence rate of Yin deficiency with blood-dryness syndrome is the highest in resting stage,the lowest factor rate is blood stasis in regressive stage.
Objective By using the factor analysis to explore the conformity traditional Chinese medicine(TCM) syndrome factors of psoriasis vulgaris clinical distribution could be provided as the evidence of data mining in TCM. Methods The clinical symptoms and signs such as tongue and pulse of the 412 patients were recorded by using questionnaire responses. By the approach of factor analysis,the common factors which dominated the variables of four diagnosis for psoriasis vulgaris were extracted,analyzed and interpreted. Results Total four common factors were included,with the highest occurrence rate of factor 2. Factor 2 represented the syndrome of blood-heat and dampness-heat. Of the deficiency syndrome,the incidence rate of syndrome of Yin deficiency with blood-dryness represented by factor 3 was the highest. The factor 4 was blood stasis with lowest rate. Conclusion The dampness-heat syndrome and the blood heat syndrome are the most common of the excessive syndromes which the two kinds of syndromes are the key pathogenesis in progressive stage. Of the deficiency syndrome,the incidence rate of Yin deficiency with blood-dryness syndrome is the highest in resting stage,the lowest factor rate is blood stasis in regressive stage.
引文
[1]Naldi L.Psoriasis[J].Dermatol Clin,1995,13:635-647.
[2]Naldi L.Epidemiology of psoriasis[J].Curr Drug Targets Inflamm Allergy,2004,3:121-128.
[3]中华医学会皮肤性病学分会银屑病学组.中国银屑病治疗指南(2008年)[J].中华皮肤科杂志,2009,42(3):213-214.
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[5]郭蕾,王永炎,张志斌.关于证候概念的诠释[J].北京中医药大学学报,2003,26(2):5-8.
[6]毕颖斐,毛静远.基于证候要素的病证结合辨治研究思路浅探[J].中华中医药杂志,2017,32(2):648-650.
[7]周炀,牟新.中医证候研究统计方法学[J].中华中医药学刊,2017,35(4):791-794.
[8]齐方洲,孔丽娅,马纲,等.基于聚类和因子分析的糖尿病早期微血管病变证素研究[J].中华中医药杂志,2017,32(2):794-797.
[9]陈启光,申春悌,张华强,等.因子分析在中医证候规范标准研究中的应用[J].中国中医基础医学杂志,2004,10(8):53-56.
[10]徐雯洁,王天芳,刘卫红,等.基于隐结构法的寻常型银屑病常见证候要素的研究[J].首都医科大学学报,2012,33(1):94-98.
[2]Naldi L.Epidemiology of psoriasis[J].Curr Drug Targets Inflamm Allergy,2004,3:121-128.
[3]中华医学会皮肤性病学分会银屑病学组.中国银屑病治疗指南(2008年)[J].中华皮肤科杂志,2009,42(3):213-214.
[4]国家中医药管理局制定发布.中医病证诊断疗效标准[S].北京:中华人民共和国卫生部国家中医药管理局,1994:ZY/TO01.1-001.9-94.
[5]郭蕾,王永炎,张志斌.关于证候概念的诠释[J].北京中医药大学学报,2003,26(2):5-8.
[6]毕颖斐,毛静远.基于证候要素的病证结合辨治研究思路浅探[J].中华中医药杂志,2017,32(2):648-650.
[7]周炀,牟新.中医证候研究统计方法学[J].中华中医药学刊,2017,35(4):791-794.
[8]齐方洲,孔丽娅,马纲,等.基于聚类和因子分析的糖尿病早期微血管病变证素研究[J].中华中医药杂志,2017,32(2):794-797.
[9]陈启光,申春悌,张华强,等.因子分析在中医证候规范标准研究中的应用[J].中国中医基础医学杂志,2004,10(8):53-56.
[10]徐雯洁,王天芳,刘卫红,等.基于隐结构法的寻常型银屑病常见证候要素的研究[J].首都医科大学学报,2012,33(1):94-98.
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