晚期食管癌同步放化疗、序贯性放化疗对比

详细信息    查看全文 | 推荐本文 |

英文篇名：Comparison of the Effects of Concurrent Chemoradiotherapy and Sequential Chemoradiotherapy in Advanced Esophageal Cancer 作者：孙丽立 ; 王乐乐 ; 尹胜杰 ; 季洪波 英文作者：SUN Lili;WANG Lele;YIN Shengjie;JI Hongbo;Department of First Internal Medicine in Oncology, Chifeng Hospital; 关键词：同步放化疗 ; 序贯性放化疗 ; 副反应 ; 晚期 ; 食管癌 ; 生存率 英文关键词：concurrent chemoradiotherapy;;sequential chemoradiotherapy;;side effects;;advanced stage;;esophageal cancer;;survival rate 中文刊名：WSBZ 英文刊名：China Health Standard Management 机构：赤峰市医院肿瘤内一科; 出版日期：2019-01-25 出版单位：中国卫生标准管理 年：2019 期：v.10 语种：中文; 页：WSBZ201902030 页数：3 CN：02 ISSN：11-5908/R 分类号：81-83

摘要

目的探讨同步放化疗、序贯性放化疗在晚期食管癌治疗中的临床效果。方法选取2014年2月—2017年2月收治的98例晚期食管癌患者作研究对象,按放化疗方案不同予以分组:同步组(n=49)采取同步放化疗方案,序贯组(n=49)采取序贯性放化疗方案,对比近期疗效以及副反应的差异。结果同步组的近期治疗有效率高于序贯组(P <0.05),且副反应发生率高于序贯组(P <0.05)。结论同步放化疗在晚期食管癌治疗中的近期疗效优于序贯性放化疗,虽会增加副反应,但患者可耐受。
        Objective To investigate the clinical effect of concurrent radiotherapy and sequential radiotherapy and chemotherapy in the treatment of advanced esophageal cancer. Methods Ninety-eight patients with advanced esophageal cancer admitted from February 2014 to February 2017 were selected as the study subjects. They were grouped according to different radiotherapy and chemotherapy schemes: synchronous group(n =49) adopted synchronous radiotherapy and chemotherapy scheme, and sequential group(n =49) adopted sequential radiotherapy and chemotherapy scheme. The short-term efficacy and side effects were compared. Results The short-term effective rate of synchronous group was higher than that of sequential group(P < 0.05), and the incidence of side effects was higher than that of sequential group(P < 0.05). Conclusion The short-term efficacy of concurrent chemoradiotherapy in the treatment of advanced esophageal cancer is better than that of sequential chemoradiotherapy. Although it can increase side effects, it is tolerable for patients.

引文

[1]陈龙奇.制订2009第7版食管癌TNM分期标准[J].中国胸心血管外科临床杂志,2008,15(1):52-55.
    [2]夏海群,华贻军,彭醒思,等.诱导化疗加放疗与同期放化疗治疗局部晚期鼻咽癌的疗效比较[J].中国肿瘤,2016,25(5):386-390.
    [3]杨学宁,吴一龙.实体瘤治疗疗效评价标准-RECIST[J].循证医学,2004,4(2):85-90.
    [4]孙晓鸣,陆雪官,陈列松,等.多烯紫杉醇联合奈达铂同步放化疗治疗局部中晚期食管癌疗效观察[J].中华实用诊断与治疗杂志,2016,30(7):719-722.
    [5]吴琴,张丹,万义学.序贯放化疗与同步放化疗对中晚期宫颈癌患者血液学毒性以及肿瘤标志物的影响[J].广西医科大学学报,2017,34(2):288-291.
    [6]王梅云,殷星,候永超,等.射频消融术联合同步放化疗并序贯化疗治疗中晚期局部非小细胞肺癌对患者生存质量的影响[J].解放军医药杂志,2016,28(S1):46-48.
    [7]石文波.两种联合放化疗方案对无淋巴结转移胸段食管癌患者近期疗效、生存时间及不良反应的影响[J].中南医学科学杂志,2017,45(2):169-171.
    [8]陆颖,黄海欣,杨慧,等.局部晚期乳腺癌改良根治术后多西他赛同步放化疗的放射性不良反应观察[J].中国肿瘤临床,2016,43(10):438-441.
    [9]朱星宇,王惠琴. NP方案化疗同步放疗并序贯过继免疫细胞治疗晚期非小细胞肺癌的疗效及安全性观察[J].陕西医学杂志,2017,46(8):1062-1063.
    [10]陆颖,黄海欣,李桂生,等.局部晚期乳腺癌改良根治术后两种辅助放化疗模式的疗效与成本效果分析[J].现代肿瘤医学,2017,25(2):209-213.
    [11]李媛媛,金风,吴伟莉,等.磁共振灌注成像在重组人血管内皮抑制素联合放化疗治疗局部晚期鼻咽癌中的临床研究[J].中华放射医学与防护杂志,2017,37(4):264-268.
    [12]刘晓梅,王晓华,周强.同步放化疗与序贯放化疗治疗Ⅲ期非小细胞肺癌的临床疗效比较[J].实用癌症杂志,2016,31(9):1476-1479.