基于锁相光子计数的多通道脑功能成像系统

详细信息    查看全文 | 推荐本文 |

英文篇名：Multi-Channel Brain Functional Imaging System Based on Lock-in Photon Counting 作者：丁雪梅 ; 王兵元 ; 刘东远 ; 张耀 ; 潘甜甜 ; 高峰 英文作者：Ding Xuemei;Wang Bingyuan;Liu Dongyuan;Zhang Yao;Pan Tiantian;Gao Feng;School of Precision Instruments & Opto-Electronics Engineering,Tianjin University;Tianjin Key Laboratory of Biomedical Detection Technology and Instrumentation; 关键词：成像系统 ; 脑功能成像技术 ; 锁相光子计数技术 ; 参考权重计数策略 ; 扩散光层析成像 ; 7次分时激励方案 英文关键词：imaging system;;brain functional imaging technology;;lock-in photon counting technology;;reference-weighted counting strategy;;diffuse optical tomography;;scheme of 7-time excitation 中文刊名：JJZZ 英文刊名：Chinese Journal of Lasers 机构：天津大学精密仪器与光电子工程学院;天津大学天津市生物医学检测技术与仪器重点实验室; 出版日期：2018-09-07 11:38 出版单位：中国激光 年：2019 期：v.46;No.505 基金：国家自然科学基金(61575140) 语种：中文; 页：JJZZ201901033 页数：7 CN：01 ISSN：31-1339/TN 分类号：262-268

摘要

功能近红外光谱成像已成为脑功能研究的首选手段。为得到高灵敏度、大动态范围以及高时间分辨率的成像系统,开发了基于改进锁相光子计数的多通道近红外脑功能成像系统。光源模块由波长为785,808,830nm的激光二极管(各16个)组成,调制方波的频率间隔为252Hz;探测模块包括9个光子计数式光电倍增管。该系统结合了单光子计数技术的超高灵敏度与方波调制模式数字锁相检测的简易并行性,测量线性相关系数可达0.9989,信道间的串扰可忽略不计,具有较强的抗干扰能力和准确的空间定位能力。
        Functional near-infrared spectroscopy imaging has become the preferred choice as a neuroimaging technique of brain function research.To obtain the imaging system with high sensitivity,large dynamic range and high temporal resolution,we develop a multi-channel near-infrared brain functional imaging system based on improved lock-in photon-counting.The light source module consists of 16 laser diodes with wavelength of 785,808 and 830 nm,respectively,which are modulated by square wave with frequency space of 252 Hz.The detection module includes nine photon counting photomultiplier tubes.This system combines the ultra-high sensitivity of the photon-counting technology with the simple parallelism of the digital lock-in detection based on square wave modulation mode,and system performance meets requirements.The linear correlation coefficient can reach 0.9989,cross talk between channels is negligible.The system has strong anti-interference ability and the ability to locate accurately.

引文

[1]Gregg N M,White B R,Zeff B W,et al.Brain specificity of diffuse optical imaging:improvements from superficial signal regression and tomography[J].Frontiers in Neuroenergetics,2010,2(14):1-8.
    [2]Ferrari M,Quaresima V.A brief review on the history of human functional near-infrared spectroscopy(fNIRS)development and fields of application[J].NeuroImage,2012,63(2):921-935.
    [3]Hoshi Y,Yamada Y.Overview of diffuse optical tomography and its clinical applications[J].Journal of Biomedical Optics,2016,21(9):091312.
    [4]Chen X S,Wang X F,Su J S,et al.Research status and development of diffuse optical tomography system[J].Laser&Infrared,2016,46(6):653-658.陈兴稣,王雪峰,苏金善,等.扩散光层析成像系统研究现状及发展[J].激光与红外,2016,46(6):653-658.
    [5]Zhao H B,Cooper R J.Review of recent progress toward a fiberless,whole-scalp diffuse optical tomography system[J].Neurophotonics,2017,5(1):011012.
    [6]Hallacoglu B,Trobaugh J W,Bechtel K L,et al.Blood phantom verification of a new compact DOTsystem[C].Fort Lauderdale:Optical Society of America,2016.
    [7]Chitnis D,Cooper R J,Dempsey L,et al.Functional imaging of the human brain using a modular,fibreless,high-density diffuse optical tomography system[J].Biomedical Optics Express,2016,7(10):4275-4288.
    [8]Chen W T,Wang X,Wang B Y,et al.Lock-inphotoncounting-based highly-sensitive and largedynamic imaging system for continuous-wave diffuse optical tomography[J].Biomedical Optics Express,2016,7(2):499-511.
    [9]Xu K X,Gao F,Zhao H J.Biomedical photonics[M].2nd ed.Beijing:Science Press,2011:100-101.徐可欣,高峰,赵会娟.生物医学光子学[M].2版.北京:科学出版社,2011:100-101.
    [10]Masciotti J M,Lasker J M,Hielscher A H.Digital lock-in detection for discriminating multiple modulation frequencies with high accuracy and computational efficiency[J].IEEE Transactions on Instrumentation and Measurement,2008,57(1):182-189.
    [11]Gao J Z.Detection of weak signals[M].2nd ed.Beijing:Tsinghua University Press,2011:155-156.高晋占.微弱信号检测[M].2版.北京:清华大学出版社,2011:155-156.
    [12]Liu Y,Luo W Q,Wang R D,et al.Sub-diffuse scattering of biological tissues and its application to spectroscopy[J].Chinese Journal of Lasers,2017,44(8):0807001.刘迎,罗雯倩,王汝丹,等.生物组织的亚扩散散射及其光谱技术的应用[J].中国激光,2017,44(8):0807001.
    [13]Ding H,Zhang Y,He J,et al.Optical topography guided semi-three-dimensional diffuse optical tomography for a multi-layer model of occipital cortex:apilot methodological study[J].Proceedings of SPIE,2016,9690:96901S.