2型糖尿病肾病患者血清晚期氧化蛋白产物与动脉粥样硬化的关系

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英文篇名：Relationship between serum advanced oxidation protein products and atherosclerosis in patients with type 2 diabetic nephropathy 作者：荣光 ; 卓华钦 ; 叶庆邦 ; 宁海欢 ; 朱咏瑶 ; 杨银广 ; 林志坚 ; 蔡茵瑜 英文作者：RONG Guang;ZHUO Hua-qin;YE Qing-bang;NING Hai-huan;ZHU Yong-yao;YANG Yin-guang;LIN Zhi-jian;CAI Yin-yu;Department of Nephrology, Third People's Hospital of Dongguan;Department of Endocrinology, Third People's Hospital of Dongguan;B-ultrasound Room, Department of Functional Examination, Third People's Hospital of Dongguan;Department of Clinical Laboratory, Third People's Hospital of Dongguan;Department of Health Management,Third People's Hospital of Dongguan; 关键词：2型糖尿病肾病 ; 2型糖尿病 ; 氧化蛋白产物 ; 动脉粥样硬化 英文关键词：Type 2 diabetic nephropathy;;Type 2 diabetes mellitus;;Advanced oxidation protein products;;Atherosclerosis 中文刊名：HAIN 英文刊名：Hainan Medical Journal 机构：东莞市第三人民医院肾内科;东莞市第三人民医院内分泌科;东莞市第三人民医院功能检查科B超室;东莞市第三人民医院检验科;东莞市第三人民医院健康管理科; 出版日期：2019-01-25 出版单位：海南医学 年：2019 期：v.30 基金：2017年广东省东莞市社会科技发展项目(编号:201750715024134) 语种：中文; 页：HAIN201902008 页数：3 CN：02 ISSN：46-1025/R 分类号：36-38

摘要

目的探讨2型糖尿病肾病患者血清晚期氧化蛋白产物(AOPP)与动脉粥样硬化的关系。方法检测2017年7月至2018年6月在东莞市第三人民医院住院治疗的50例2型糖尿病肾病(非透析)患者、30例单纯2型糖尿病患者(无并发症)及30例健康体检者血清AOPP的含量,彩色多普勒超声测量颈动脉内中膜厚度(IMT)。通过多变量偏相关分析研究AOPP与动脉粥样硬化的相关性。结果 2型糖尿病肾病组及单纯2型糖尿病组患者血清AOPP[(76.83±4.96)μmol/L、(60.28±3.92)μmol/L]较健康对照组[(26.91±2.18)μmol/L]显著升高,差异均有统计学意义(P<0.05);2型糖尿病肾病患者中IMT正常组患者的血清AOPP为(35.28±3.92)μmol/L,明显低于IMT增厚组的(61.83±4.96)μmol/L,差异有统计学意义(P<0.05);且多变量相关分析表明,血清AOPP与颈动脉IMT值呈显著正相关性(r=0.335,P<0.01)。结论 2型糖尿病肾病患者血清AOPP与颈动脉IMT呈正相关,可能促进2型糖尿病肾病患者动脉粥样硬化的发生发展。
        Objective To explore the relationship between advanced oxidation protein products(AOPP) and atherosclerosis(AS) in patients with type 2 diabetic nephropathy. Methods A total of 50 patients with type 2 diabetic nephropathy(non-dialysis) hospitalized in the Third People's Hospital of Dongguan from July 2017 to June 2018, 30 patients with type 2 diabetes mellitus(without complications), and 30 healthy subjects were examined for AOPP content.The mean intima-media thickness(IMT) of carotid artery was measured by ultrasonography. Correlation between AOPP and atherosclerosis was studied by multivariate partial correlation analysis. Results Serum AOPP in the type 2 diabetic nephropathy group and the type 2 diabetes mellitus group were(76.83±4.96) μmol/L,(60.28±3.92) μmol/L, significantly higher than(26.91±2.18) μmol/L in the healthy control group(P<0.05). Serum AOPP in type 2 diabetic nephropathy patients with normal IMT was(35.28±3.92) μmol/L, which was significantly lower than(61.83±4.96) μmol/L in the patients with IMT thickening(P<0.05). Multivariate correlation analysis showed a significant positive correlation between serum AOPP and carotid IMT(r=0.335, P<0.01). Conclusion In patients with type 2 diabetic nephropathy, AOPP was positively correlated with carotid artery IMT and may involved in the occurrence and development of atherosclerosis.

引文

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