清热调经汤治疗排卵性功能失调性子宫出血临床研究

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英文篇名：Efficacy of Qingre Tiaojing decoction in treating dysfunctional uterine bleeding 作者：王广洁 英文作者：WANG Guangjie;The Third Affiliated Hospital of Henan University of Traditional Chinese Medicine; 关键词：排卵性功能失调 ; 子宫出血 ; 黄体酮 ; 清热调经汤 ; 血液流变学 ; 临床疗效 英文关键词：Dysfunctional uterine bleeding;;Uterine bleeding;;Flavonoids;;Qingre Tiaojing decoction;;Hemorheology;;Clinical efficacy 中文刊名：SXZY 英文刊名：Shaanxi Journal of Traditional Chinese Medicine 机构：河南中医药大学第三附属医院; 出版日期：2019-02-05 出版单位：陕西中医 年：2019 期：v.40;No.446 基金：河南省中医药科技计划专项课题(2015ZY084) 语种：中文; 页：SXZY201902020 页数：3 CN：02 ISSN：61-1105/R 分类号：74-76

摘要

目的:分析自拟清热调经汤治疗排卵性功能失调性子宫出血(DUB)的疗效。方法:将因排卵性功能失调性子宫出血的127例患者作为研究对象,采用随机分组方法将所有患者分为观察组与对照组。其中对照组采用倍美力与黄体酮治疗;观察组在对照组用药基础上加用清热调经汤行联合治疗。对比两组临床疗效、症状缓解程度及子宫出血情况的差异。结果:观察组治疗总有效率显著高于对照组(P<0.05);两组临床症状总积分在治疗后均显著降低,且观察组降低程度较对照组更加显著(P<0.05);观察组出血控制时间及完全止血所需时间较对照组明显更短(P<0.05)。结论:自拟清热调经汤在DUB患者临床治疗中的应用可有效改善患者多项临床症状,控制出血情况发生,并减少止血时间,疗效显著。
        Objective:To analyze the effect of Qingre Tiaojing decoction on dysfunctional uterine bleeding(DUB).Methods:127 patients with dysfunctional uterine bleeding were divided into observation group and control group by random grouping method.The control group was treated with Beimeili and Flavonoids,while the observation group was treated with Qingre Tiaojing decoction on the basis of the control group.The clinical efficacy,symptom relief and uterine bleeding were compared between the two groups.Results:The total effective rate of the observation group was significantly higher than that of the control group(P<0.05).The total scores of clinical symptoms in both groups were significantly reduced after treatment,and the degree of reduction in the observation group was more significant than that in the control group(P<0.05);the time required for hemorrhage control and complete hemostasis in the observation group was significantly shorter than that in the control group(P<0.05).Conclusion:The application of Qingre Tiaojing decoction in clinical treatment of DUB patients can effectively improve a number of clinical symptoms,control the occurrence of bleeding,and reduce the time of hemostasis.

引文

[1]杨江华,高琴,白帆,等.固冲汤加减方联合西药治疗无排卵性功能失调性子宫出血疗效观察[J].陕西中医,2017,38(7):819-820.
    [2] Schatz F,Guzeloglukayisli O,Arlier S,et al.The role of decidual cells in uterine hemostasis,menstruation,inflammation,adverse pregnancy outcomes and abnormal uterine bleeding[J].Human Reproduction Update,2016,22(4):497.
    [3]柳先廉,刘燕燕,袁秀英,等.复方益母草胶囊联合屈螺酮炔雌醇片治疗青春期功能失调性子宫出血的效果[J].广东医学,2016,37(z1):238-240.
    [4] Martinelli I,Lensing A W,Middeldorp S,et al.Recurrent venous thromboembolism and abnormal uterine bleeding with anticoagulant and hormone therapy use[J].Blood,2016,127(11):1417-1425.
    [5]申铁英.小剂量米非司酮联合补肾固冲汤治疗围绝经期功能失调性子宫出血的临床效果[J].世界中西医结合杂志,2017,12(4):538-540.
    [6]王国建.功能失调性子宫出血发病机制和治疗进展[J].世界最新医学信息文摘,2015,15(36):129-130.
    [7]唐华栋,王慧英,郝增平,等.子宫内膜息肉与异常子宫出血的相关特点分析[J].中国妇产科临床杂志,2014,15(1):29-32.
    [8]国家食品药品监督管理总局.中药新药临床研究指导原则[J].现代中西医结合杂志,2002:149-150.
    [9]崔敏,曹树军,原玮.加味补脾益肾止血汤结合西药治疗青春期功能失调性子宫出血疗效观察[J].现代中西医结合杂志,2017,26(32):3610-3612.
    [10]万金华,许义芳.清热祛瘀汤配合黄体酮胶丸治疗围绝经期功能失调性子宫出血[J].吉林中医药,2017,37(10):1008-1011.
    [11]杨秀芳,李清雪,朱希慧,等.补肾固冲调经系列方治疗脾肾两虚型无排卵性功能失调性子宫出血近期和远期疗效及对凝血功能安全性的观察[J].中国妇幼保健,2017,32(2):236-238.
    [12]汤婷,倪光夏.自拟清热祛瘀益肾汤联合环磷酰胺治疗早期狼疮性肾炎疗效观察[J].现代中西医结合杂志,2017,26(31):3432-3434.
    [13]岳明明,孙炜星,沙塔娜提·穆罕默德.中西医结合治疗对气虚血瘀型无排卵性功能失调性子宫出血患者子宫内膜厚度、生殖激素及炎性因子水平的影响[J].中国卫生检验杂志,2017,23(14):1987-1989.
    [14]刘国华,文洁珍.自拟清热平喘汤对小儿重症病毒性肺炎(风热闭肺证)免疫功能、炎症因子和中医证候积分的影响[J].中国中医急症,2016,25(10):1952-1954.
    [15]陈佑生,魏蕾.自拟清热解毒汤保留灌肠联合乌司他丁治疗重症肺炎合并脓毒症疗效及对凝血纤溶系统及免疫炎性反应影响[J].现代中西医结合杂志,2017,26(35):3949-3951.