金银花中的化学成分及其药理作用研究进展
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摘要
金银花是一种具有悠久历史的常用中药,具有清热解毒、宣散风热的功效,集中分布于河南、山东、广东等地。金银花的化学成分主要包括有机酸类、黄酮类、环烯醚萜苷类、三萜皂苷类、挥发油类以及其他各种成分。金银花的药理作用主要为抗炎解热,抗肿瘤,抗菌抗病毒,抗衰老抗氧化,降低血糖,保肝,保护肺脏,神经保护作用,增强机体免疫功能以及抗血小板聚集等。因其具有丰富的药理作用,药用价值高,常可与多种其他药物配伍用于多种方剂之中,临床应用广泛,社会需求量大。本文通过查阅近几年金银花的化学成分及其药理作用方面的相关文献,了解到多名学者对其进行研究并从金银花中首次分离得到多种新的化学成分且对金银花的药理作用机制进了详细研究,因此通过整理相关研究结果,对其进行归纳总结,为更多人认识并了解金银花的最新研究进展提供参考,也可为金银花的开发利用提供科学依据。
Lonicerae Japonicae Flos is a commonly used traditional Chinese medicine with a long history.It has the functions of detoxification,heat dissipation and heat dissipation,with a high medicinal value.It is mainly distributed in Henan,Shandong,Guangdong and other places.Researches have shown that the chemical constituents of honeysuckle mainly include organic acids,flavonoids,iridoid glycosides,three terpenoid glycosides,three terpenoid glycosides and volatile oils.And the pharmacological effects of honeysuckle are mainly antiinflammation and antipyretic,anti-tumor,anti-bacteria,anti-virus,anti-aging and anti-oxidation,lowering blood sugar,protecting liver,protecting lung,neuroprotective,enhancing immune function and anti-platelet aggregation.Because of its rich pharmacological effects and high medicinal value,it has been used in a variety of prescriptions,with wide clinical applications and its large social demands.In this paper,we have reviewed the literatures on the chemical constituents and pharmacological effects of honeysuckle in recent years,and learned that many scholars have studied it,isolated a variety of new chemical components from honeysuckle for the first time and studied the pharmacological effects of honeysuckle in detail.In this paper,we reviewed the research progress of chemical constituents and pharmacological effects of Lonicerae Japonicae Flos,providing references for more people to learn related knowledge of honeysuckle and a scientific basis for the development and utilization of Lonicerae Japonicae Flos.
Lonicerae Japonicae Flos is a commonly used traditional Chinese medicine with a long history.It has the functions of detoxification,heat dissipation and heat dissipation,with a high medicinal value.It is mainly distributed in Henan,Shandong,Guangdong and other places.Researches have shown that the chemical constituents of honeysuckle mainly include organic acids,flavonoids,iridoid glycosides,three terpenoid glycosides,three terpenoid glycosides and volatile oils.And the pharmacological effects of honeysuckle are mainly antiinflammation and antipyretic,anti-tumor,anti-bacteria,anti-virus,anti-aging and anti-oxidation,lowering blood sugar,protecting liver,protecting lung,neuroprotective,enhancing immune function and anti-platelet aggregation.Because of its rich pharmacological effects and high medicinal value,it has been used in a variety of prescriptions,with wide clinical applications and its large social demands.In this paper,we have reviewed the literatures on the chemical constituents and pharmacological effects of honeysuckle in recent years,and learned that many scholars have studied it,isolated a variety of new chemical components from honeysuckle for the first time and studied the pharmacological effects of honeysuckle in detail.In this paper,we reviewed the research progress of chemical constituents and pharmacological effects of Lonicerae Japonicae Flos,providing references for more people to learn related knowledge of honeysuckle and a scientific basis for the development and utilization of Lonicerae Japonicae Flos.
引文
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[2]LIU Q,LIU S,GAO L,et al.Anti-diabetic effects and mechanisms of action of a Chinese herbal medicine preparation JQ-R in vitro and in diabetic KK(Ay)mice[J].Acta Pharm Sin B,2017,7(4):461-469.
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[4]王旭,周洪雷,容蓉.金银花化学成分研究[J].中药材,2016,39(9):2030-2032.
[5]JIANG N H.Study on Chemical Constituents of Lonicera japonica Bud[J].Chin Tradit Herb Drugs,2015,38(2):315-317.
[6]NI F Y,LIU L,SONG Y L,et al.Anti-complementary phenolic acids from Lonicera japonica[J].China J Chin Mater Med,2015,40(2):269-74.
[7]LIU Z,CHENG Z,HE Q,et al.Secondary metabolites from the flower buds of Lonicera japonica and their in vitro anti-diabetic activities[J].Fitoterapia,2016,110:44-51.
[8]Lo I W,CHENG Y B,Hsieh Y J,et al.Chemical constituents and LC-profile of fresh formosan Lonicera japonica flower buds[J].Nat Prod Commun,2016,11(1):1-4.
[9]WANG F,JIANG Y P,WANG X L,et al.Chemical constituents from flower buds of Lonicera japonica[J].China J Chin Mater Med,2013,38(9):1378-1385.
[10]LI H B,YU Y,MEI Y D,et al.A new hetero dimeric terpenoid derivative,japonicaside C,from the flower buds of Lonicera japonica[J].Nat Prod Res,2017,31(2):143-148.
[11]李泮霖,李楚源,刘孟华,等.基于UF LC-Triple-Q-TOF-MS/MS技术的金银花、山银花化学成分比较[J].中南药学,2016,14(4):363-369.
[12]李畅,戴毅,张金博,等.金银花中1个新的环烯醚萜苷类化合物[J].中草药,2013,44(21):2951-2954.
[13]YANG B,MENG Z,MA Y,et al.One New Conjugate of a Secoiridoid Glucoside with a Sesquiterpene Glucoside from the Flower Buds of Lonicera japonica[J].Nat Prod Commun,2015,10(9):1499-1500.
[14]GE W,LI H B,FANG H,et al.A new dimeric secoiridoids derivative,japonicaside E,from the flower buds of Lonicera japonica[J].Nat Prod Res,2018,3:1-6.
[15]YU Y,SONG W X,GUO Q L,et al.Studies on chemical constituents of aqueous extract of Lonicera japonica flower buds[J].China J Chin Mater Med,2015,40(17):3496-3504.
[16]YANG J,LI Y C,ZHOU X R,et al.Two thymol derivatives from the flower buds of Lonicera japonica and their antibacterial activity[J].Nat Prod Res,2017:1-6.
[17]YU Y,ZHU C,WANG S,et al.Homosecoiridoid alkaloids with amino acid units from the flower buds of Lonicera japonica[J].J Nat Prod,2013,76(12):2226-2233.
[18]WANG F,JIANG Y P,WANG X L,et al.Aromatic glycosides from the flower buds of Lonicera japonica[J].J Asian Nat Prod Res,2013,15(5):492-501.
[19]冯秀丽,许庆华,赵晓云,等.金银花及其复方的体外抑菌活性与体内抗炎作用[J].沈阳药科大学学报,2013,30(1):35-39,62.
[20]Kwon S H,MA S X,HONG S I,et al.Lonicera japonica THUNB.extract inhibits lipopolysaccharidestimulated inflammatory responses by suppressing NF-kappa B signaling in BV-2 microglial cells[J].J Med Food,2015,18(7):762-775.
[21]王亚琼,陈卫,钟水生,等.金银花清热解毒作用的血清代谢组学研究[J].中药材,2016,39(5):1129-1133.
[22]Park J W,Bae H,Lee G,et al.Prophylactic effects of Lonicera japonica extract on dextran sulphate sodiuminduced colitis in a mouse model by the inhibition of the Th1/Th17 response[J].Br J Nutr,2013,109(2):283-292.
[23]HONG S H,Kwon J T,Shin J Y,et al.Therapeutic effect of Broussonetia papyrifera and Lonicera japonica in ovalbumin-induced murine asthma model[J].Nat Prod Commun,2013,8(11):1609-1614.
[24]杜江.金银花主要成分绿原酸对RSV感染RAW264.7细胞的TLR3信号通路的影响[J].齐齐哈尔医学院学报,2017,38(6):626-628.
[25]Lee Y R,Yeh S F,RUAN X M,et al.Honeysuckle aqueous extract and induced let-7a suppress dengue virus type 2 replication and pathogenesis[J].JEthnopharmacol,2017,198:109-121.
[26]朱琳枫,鲍欣欣,姚辉,等.金银花和鱼腥草抑制甲型流感病毒体外复制研究[J].国际检验医学杂志,2018,39(4):485-486.
[27]胡燕敏,周爱梅,宋倩,等.4种中草药提取液的工艺优化及其抗菌效果对比[J].食品安全质量检测学报,2017,8(8):3169-3176.
[28]赵蓓蓓,赵晶,王志铮,等.10种常见中草药水提物对嗜水气单胞菌ZHYYZ-1的体外抑菌效果研究[J].浙江海洋学院学报:自然科学版,2012,31(4):316-320.
[29]李黎,孙晶.多倍体金银花与二倍体金银花不同部位提取物的抑菌作用及绿原酸含量的比较研究[J].食品科技,2012,37(8):225-227,231.
[30]YANG L,Aguilar Z P,QU F,et al.Enhanced antimicrobial activity of silver nanoparticles-Lonicera japonica Thunb combo[J].IET Nanobiotechnol,2016,10(1):28-32.
[31]朱小峰,朱晓娣,王金梅.封丘产金银花不同提取物的体外抗氧化、抗凝血及α-葡萄糖苷酶抑制活性研究[J].中国药房,2016,27(34):4804-4806.
[32]田磊,蒋宝平,何苗,等.金银花-山银花水提液不同配比体外抗氧化作用研究[J].实用药物与临床,2014,17(10):1290-1294.
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