基底细胞癌诊治的研究进展
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摘要
皮肤基底细胞癌(BCC)是来源于基底细胞的低度皮肤恶性肿瘤,世界范围内较常见,转移率低,但局部破坏性大。随着人们生活水平的提高,平均寿命延长、户外活动日益增多、中国人口老龄化的现状,其患病率不断上升,加之BCC皮损的多样性,误诊率较高,因而日益受到人们的关注。BCC的诊断主要根据临床特征及组织病理学检查,皮肤影像学检查可作为无创性初筛的选择。为了减少其对人体的危害,BCC的治疗主要以安全切除和防止复发为主要目的。治疗方法多样,根据肿物的特点及个人体质情况决定,包括手术、冷冻、激光、外用药物治疗、化疗、放疗及联合治疗等。
Basal cell carcinoma( BCC) is a low-grade malignant skin tumor originating from basal cells. It is common in the world,with low metastasis rate but high local destruction. With the improvement of people's living standards,the average life spans,the increasing number of outdoor activities,the present situation of the aging of China's population,the diversity of BCC skin lesions,the high misdiagnosis rate,and the increasing incidence,the disease has attracted more and more attention. The diagnosis of BCC is mainly based on clinical features and histopathology,and the skin imaging examination can be used as a non-invasive screening selection. In order to reduce the harm to human body,the main purpose of the treatment is to remove BCC safely and prevent recurrence. There are many treatments,including surgical treatment,liquid nitrogen frozen,laser therapy,topical medication,chemotherapy,radiotherapy and combination therapy,which are Chosen according to the characteristics of the tumor and the physical condition of the individual.
Basal cell carcinoma( BCC) is a low-grade malignant skin tumor originating from basal cells. It is common in the world,with low metastasis rate but high local destruction. With the improvement of people's living standards,the average life spans,the increasing number of outdoor activities,the present situation of the aging of China's population,the diversity of BCC skin lesions,the high misdiagnosis rate,and the increasing incidence,the disease has attracted more and more attention. The diagnosis of BCC is mainly based on clinical features and histopathology,and the skin imaging examination can be used as a non-invasive screening selection. In order to reduce the harm to human body,the main purpose of the treatment is to remove BCC safely and prevent recurrence. There are many treatments,including surgical treatment,liquid nitrogen frozen,laser therapy,topical medication,chemotherapy,radiotherapy and combination therapy,which are Chosen according to the characteristics of the tumor and the physical condition of the individual.
引文
[1] Marzuka AG,Book SE. Basal cell carcinoma:Pathogenesis,epidemiology,clinical features,diagnosis,histopathology,and management[J]. Yale J Biol Med,2015,88(2):167-179.
[2]白冠军,任衍钢,宋玉奇,等.紫外线诱导DNA损伤及修复研究的起因与发展[J].生物学通报,2017,52(3):58-62.
[3] Verkouteren JAC,Ramdas KHR,Wakkee M,et al. Epidemiology of basal cell carcinoma:Scholarly review[J]. Br J Dermatol,2017,177(2):359-372.
[4] Dubin N,Kopf AW. Multivariate risk score for recurrence of cutaneous basal cell carcinomas[J]. Arch Dermatol,1983,119(3):373-377.
[5]刘妍,刘丁,熙高丽. ALA-PDT联合手术治疗皮肤基底细胞癌的中远期疗效观察[J].临床和实验医学杂志,2018,17(4):415-418.
[6] Endo M,Fujii K,Sugita K,et al. Nationwide survey of nevoid basal cell carcinoma syndrome in Japan revealing the low incidence of basal cell carcinoma[J]. Med Genet A,2012,158A(2):351-357.
[7] Huang YS,Chen XX,Yang SX,et al. Preliminary exploration of the clinical features of Chinese patients with skin malignancies and premalignancies:A retrospective study of 1420 cases from Peking University First Hospital[J]. J Eur Acad Dermatol Venereol,2013,27:1114-1119.
[8] Trigoni A,Lazaridou E,Apalla Z,et al. Dermoscopic features in the diagnosis of different types of basal cell carcinoma:A prospective analysis[J]. Hippokratia,2012,16(1):29-34.
[9] Rosendahl C,Tschandl P,Cameron A,et al. Diagnostic accuracy of dermatoscopy for melanocytic and nonmelanocytic pigmented lesions[J]. J Am Acad Dematol,2011,64(6):1068-1073.
[10]陈自学,周美杉,涂平,等. 418例基底细胞癌病例临床病理特点回顾分析[J].北京大学学报(医学版),2014,46(2):195-199.
[11]刘华绪,郑志忠,任秋实.基于光学共聚焦原理的皮肤在体三维成像系统及应用[J].中华皮肤科杂志,2006,39(10):616-619.
[12]钟连生,金鑫,权晟,等.基底细胞癌的共聚焦激光扫描显微镜图像特征[J].中国皮肤性病学杂志,2013,27(7):683-685.
[13] Ulrich M,Lange-Asschenfeldt S. In vivo confocal microscopy in dermatology:From research to clinical application[J]. J Biomed Opt,2013,18(6):212.
[14]马丽莉.皮肤基底细胞癌35例临床病理分析[J].齐齐哈尔医学院报,2015,36(14):2086-2087.
[15] Vega Memije ME,Luna EM,de Almeida OP,et al. Immunohistochemistry panel for differential diagnosis of Basal cell carcinoma and trichoblastoma[J]. Int J Trichology,2014,6(2):40-44.
[16]吴雪梅,王小明,郭少峰,等.皮肤毛母细胞瘤与基底细胞癌的临床病理鉴别诊断[J].诊断病理学杂志,2018,25(3):201-204.
[17] Trekatelli M,Morton C,Nagore E,et al. Update of the European guidelines for basal cell carcinoma management[J]. Eur J Dermatol,2014,24(3):312-329.
[18]张娅,王明刚,周杭城.面部基底细胞癌临床病理分析及安全切缘的关系[J].临床与实验病理学杂志,2017,33(1):68-72.
[19]程定,马少林.基底细胞癌临床治疗现状[J].实用肿瘤学杂志,2010,9(4):77-80.
[20]陆升,全超坤,张龙城.手术切除联合额瓣修复治疗鼻部基底细胞癌40例临床分析[J].临床耳鼻咽喉头颈外科杂志,2017,31(6):477-479.
[21] Page DL,Fleming ID,Fritz A,et al. AJCC cancer staging manual[M].6th ed. New York:Springer-Verlag,2002:47-60.
[22] Komorowska-timek E,Gabriel A,Bennett DC,et al. Artificial dermis as an alternative for coverage of complex scalp defects following excision of malignant tumors[J]. Plast Reconstr Surg,2005,115(4):1010-1017.
[23]袁好军,安静,孙宇航,等.帽状腱膜下筋膜瓣加植皮一期修复头皮大面积缺损伴颅骨外露[J].中国美容医学,2014,23(7):526-528.
[24]张钦武,章国友,朱清明. Mohs显微外科手术在鼻部基底细胞癌治疗中的应用[J].中国现代医学杂志,2015,25(6):70-72.
[25]陈俊,孙褀琳,刘洋,等. Mohs显微描记手术在鼻部皮肤基底细胞癌治疗的应用[J].组织工程与重建外科学杂志,2015,11(3):163-165.
[26]何晓锋,肖越勇.肿瘤冷冻免疫及联合细胞免疫治疗的现状与进展[J].中华放射学杂志,2013,47(4):381-384.
[27]田佳新一,闫宏岭,谷志平,等.外鼻皮肤癌的冷冻治疗临床观察[J].中国耳鼻咽喉头颈外科,2014,21(3):155-156.
[28]康康,韩明辉,丛明,等.艾拉光动力联合咪喹莫特对基底细胞癌患者免疫指标的影响[J].肿瘤药学,2018,8(2):258-261.
[29]唐春雷,解德升,冯柏年.基底细胞癌新型治疗药物vismodegib[J].中国新药杂志,2013,22(10):1111-1114.
[30]诺华抗癌药Odomzo获欧盟批准治疗局部晚期基底细胞癌[J].中国新药杂志,2015(16):1805.
[31] Kim DJ,Kim J,Spaunhurst K,et al. Open-label,exploratory phaseⅡtrial of oral itraconazole for the treatment of basal cell carcinoma[J]. J Clin Oncol,2014,32(8):745-751.
[32] Yin VT,Pfeiffer ML,Esmaeli B. Targeted therapy for orbital and periocular basal cell carcinoma and squamous cell carcinoma[J].Ophthalmic Plast Reconstr Surg,2013,29(2):87-92.
[33]汪治国,张庆波.氨基酮戊酸光动力疗法治疗基底细胞癌[J].中国激光医学杂志,2013,22(4):208-211.
[34]刘盛秀,沈颂科,陈静,等.钬激光联合光动力治疗头面部难治性基底细胞癌和鳞状细胞癌疗效评价[J].中国麻风皮肤病杂志,2017,33(8):457-460.
[35]廖晓容.基底细胞癌的治疗进展[J].皮肤病与性病,2017,39(1):31-32.
[36]曹敏丽,李莎,吕建红.超声对重离子束治疗浅表肿瘤疗效的评价[J].中国临床医学影像杂志,2009,20(6):479-480.
[37]赵晓娟,张晨.明胶酶在皮肤基底细胞癌和鳞状细胞癌组织中的表达及意义[J].江苏大学学报(医学版),2011,21(1):62-64.
[38]魏翠萍.氨基酮戊酸光动力疗法、手术及咪喹莫特联合治疗皮肤基底细胞癌的疗效[J].科技世界,2016(22):272.
[39] Torres T,Fernandes I,Costa V,et al. Photodynamic therapy as adjunctive therapy for morpheaform basal cell carcinoma[J]. Acta Dermatovenerol Alp Pannonica Adriat,2011,20(1):23-25.
[2]白冠军,任衍钢,宋玉奇,等.紫外线诱导DNA损伤及修复研究的起因与发展[J].生物学通报,2017,52(3):58-62.
[3] Verkouteren JAC,Ramdas KHR,Wakkee M,et al. Epidemiology of basal cell carcinoma:Scholarly review[J]. Br J Dermatol,2017,177(2):359-372.
[4] Dubin N,Kopf AW. Multivariate risk score for recurrence of cutaneous basal cell carcinomas[J]. Arch Dermatol,1983,119(3):373-377.
[5]刘妍,刘丁,熙高丽. ALA-PDT联合手术治疗皮肤基底细胞癌的中远期疗效观察[J].临床和实验医学杂志,2018,17(4):415-418.
[6] Endo M,Fujii K,Sugita K,et al. Nationwide survey of nevoid basal cell carcinoma syndrome in Japan revealing the low incidence of basal cell carcinoma[J]. Med Genet A,2012,158A(2):351-357.
[7] Huang YS,Chen XX,Yang SX,et al. Preliminary exploration of the clinical features of Chinese patients with skin malignancies and premalignancies:A retrospective study of 1420 cases from Peking University First Hospital[J]. J Eur Acad Dermatol Venereol,2013,27:1114-1119.
[8] Trigoni A,Lazaridou E,Apalla Z,et al. Dermoscopic features in the diagnosis of different types of basal cell carcinoma:A prospective analysis[J]. Hippokratia,2012,16(1):29-34.
[9] Rosendahl C,Tschandl P,Cameron A,et al. Diagnostic accuracy of dermatoscopy for melanocytic and nonmelanocytic pigmented lesions[J]. J Am Acad Dematol,2011,64(6):1068-1073.
[10]陈自学,周美杉,涂平,等. 418例基底细胞癌病例临床病理特点回顾分析[J].北京大学学报(医学版),2014,46(2):195-199.
[11]刘华绪,郑志忠,任秋实.基于光学共聚焦原理的皮肤在体三维成像系统及应用[J].中华皮肤科杂志,2006,39(10):616-619.
[12]钟连生,金鑫,权晟,等.基底细胞癌的共聚焦激光扫描显微镜图像特征[J].中国皮肤性病学杂志,2013,27(7):683-685.
[13] Ulrich M,Lange-Asschenfeldt S. In vivo confocal microscopy in dermatology:From research to clinical application[J]. J Biomed Opt,2013,18(6):212.
[14]马丽莉.皮肤基底细胞癌35例临床病理分析[J].齐齐哈尔医学院报,2015,36(14):2086-2087.
[15] Vega Memije ME,Luna EM,de Almeida OP,et al. Immunohistochemistry panel for differential diagnosis of Basal cell carcinoma and trichoblastoma[J]. Int J Trichology,2014,6(2):40-44.
[16]吴雪梅,王小明,郭少峰,等.皮肤毛母细胞瘤与基底细胞癌的临床病理鉴别诊断[J].诊断病理学杂志,2018,25(3):201-204.
[17] Trekatelli M,Morton C,Nagore E,et al. Update of the European guidelines for basal cell carcinoma management[J]. Eur J Dermatol,2014,24(3):312-329.
[18]张娅,王明刚,周杭城.面部基底细胞癌临床病理分析及安全切缘的关系[J].临床与实验病理学杂志,2017,33(1):68-72.
[19]程定,马少林.基底细胞癌临床治疗现状[J].实用肿瘤学杂志,2010,9(4):77-80.
[20]陆升,全超坤,张龙城.手术切除联合额瓣修复治疗鼻部基底细胞癌40例临床分析[J].临床耳鼻咽喉头颈外科杂志,2017,31(6):477-479.
[21] Page DL,Fleming ID,Fritz A,et al. AJCC cancer staging manual[M].6th ed. New York:Springer-Verlag,2002:47-60.
[22] Komorowska-timek E,Gabriel A,Bennett DC,et al. Artificial dermis as an alternative for coverage of complex scalp defects following excision of malignant tumors[J]. Plast Reconstr Surg,2005,115(4):1010-1017.
[23]袁好军,安静,孙宇航,等.帽状腱膜下筋膜瓣加植皮一期修复头皮大面积缺损伴颅骨外露[J].中国美容医学,2014,23(7):526-528.
[24]张钦武,章国友,朱清明. Mohs显微外科手术在鼻部基底细胞癌治疗中的应用[J].中国现代医学杂志,2015,25(6):70-72.
[25]陈俊,孙褀琳,刘洋,等. Mohs显微描记手术在鼻部皮肤基底细胞癌治疗的应用[J].组织工程与重建外科学杂志,2015,11(3):163-165.
[26]何晓锋,肖越勇.肿瘤冷冻免疫及联合细胞免疫治疗的现状与进展[J].中华放射学杂志,2013,47(4):381-384.
[27]田佳新一,闫宏岭,谷志平,等.外鼻皮肤癌的冷冻治疗临床观察[J].中国耳鼻咽喉头颈外科,2014,21(3):155-156.
[28]康康,韩明辉,丛明,等.艾拉光动力联合咪喹莫特对基底细胞癌患者免疫指标的影响[J].肿瘤药学,2018,8(2):258-261.
[29]唐春雷,解德升,冯柏年.基底细胞癌新型治疗药物vismodegib[J].中国新药杂志,2013,22(10):1111-1114.
[30]诺华抗癌药Odomzo获欧盟批准治疗局部晚期基底细胞癌[J].中国新药杂志,2015(16):1805.
[31] Kim DJ,Kim J,Spaunhurst K,et al. Open-label,exploratory phaseⅡtrial of oral itraconazole for the treatment of basal cell carcinoma[J]. J Clin Oncol,2014,32(8):745-751.
[32] Yin VT,Pfeiffer ML,Esmaeli B. Targeted therapy for orbital and periocular basal cell carcinoma and squamous cell carcinoma[J].Ophthalmic Plast Reconstr Surg,2013,29(2):87-92.
[33]汪治国,张庆波.氨基酮戊酸光动力疗法治疗基底细胞癌[J].中国激光医学杂志,2013,22(4):208-211.
[34]刘盛秀,沈颂科,陈静,等.钬激光联合光动力治疗头面部难治性基底细胞癌和鳞状细胞癌疗效评价[J].中国麻风皮肤病杂志,2017,33(8):457-460.
[35]廖晓容.基底细胞癌的治疗进展[J].皮肤病与性病,2017,39(1):31-32.
[36]曹敏丽,李莎,吕建红.超声对重离子束治疗浅表肿瘤疗效的评价[J].中国临床医学影像杂志,2009,20(6):479-480.
[37]赵晓娟,张晨.明胶酶在皮肤基底细胞癌和鳞状细胞癌组织中的表达及意义[J].江苏大学学报(医学版),2011,21(1):62-64.
[38]魏翠萍.氨基酮戊酸光动力疗法、手术及咪喹莫特联合治疗皮肤基底细胞癌的疗效[J].科技世界,2016(22):272.
[39] Torres T,Fernandes I,Costa V,et al. Photodynamic therapy as adjunctive therapy for morpheaform basal cell carcinoma[J]. Acta Dermatovenerol Alp Pannonica Adriat,2011,20(1):23-25.
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