不同强度有氧+力量混合运动对老年大鼠海马神经发生的影响
摘要
目的研究不同强度有氧+力量混合运动对老年大鼠成年海马神经发生的影响。方法 18月龄雄性Wistar大鼠随机分成小强度运动组(SL组),中强度运动组(ML组),大强度运动组(HL组)和对照组(CG组)。8 w后进行水迷宫测试和免疫组化染色检查。结果水迷宫测试:与CG组相比,SL组和ML组潜伏期显著降低(P<0.01),随着运动强度升高,潜伏期呈增高趋势(P<0.01);SL组和ML组穿越虚拟平台次数显著增多(P<0.01),随着运动强度提高,穿越平台次数呈降低趋势(P<0.01)。免疫组化:SL组和ML组5-溴脱氧尿嘧啶核苷(Brd U)阳性神经元显著增多(P<0.01)。结论中小强度有氧+力量混合运动能够促进老年大鼠海马神经发生,并提高空间认知能力。
引文
1刘加强,童卫.海马神经发生障碍与阿尔兹海默病发病机制[J].神经解剖学杂志,2014;30(2):244-8.
2 Bj9rklund A,Lindvall O.Self-repair in the brain[J].Nature,2000;405(6789):892-3,895.
3 Ming GL,Song H.Adult neurogenesis in the mammalian brain:significant answers and significant questions[J].Neuron,2011;70(4):687-702.
4 Altman J,Das GD.Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats[J].J Comp Neurol,1965;124(3):319-35.
5 Lazarov O,Marr RA.Neurogenesis and Alzheimer's disease:at the crossroads[J].Exp Neurol,2009;223(2):267-81.
6 Pereira AC,Huddleston DE,Brickman AM,et al.An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus[J].Proc Nat Acad Sci U S A,2007;104(13):5638-43.
7 Hamer M,Chida Y.Physical activity and risk of neurodegenerative disease:a systematic review of prospective evidence[J].Psychol Med,2009;39(1):3-11.
8 Smith PJ,Blumenthal JA,Hoffman BM,et al.Aerobic exercise and neurocognitive performance:a meta-analytic review of randomized controlled trials[J].Psychosom Med,2010;72(3):239-52.
9 Snyder JS,Cahill SP,Frankland PW.Running promotes spatial bias independently of adult neurogenesis[J].Hippocampus,2017;27(8):871-82.
10 Mastrorilli V,Scopa C,Saraulli D,et al.Physical exercise rescues defective neural stem cells and neurogenesis in the adult subventricular zone of Btg1 knockout mice[J].Brain Struct Funct,2017;222(6):2855-76.
11 于淼,蓝永生.有氧+力量混合运动预防骨质疏松的作用研究[J].科技资讯,2017;15(1):196.
12 Heck H,Mader A,Hess G,et al.Justification of the 4-mmol/L lactate threshold[J].Int J Sports Med,1985;6(3):117-30.
13 Tomas-Carus P,Ortega-Alonso A,Pietilinen K,et al.A randomized controlled trial on the effects of combined aerobic-resistance exercise on muscle strength and fatigue,glycemic control and health-related quality of life of type 2 diabetes patients[J].J Sports Med Phys Fitness,2016;56(5):572-8.
14 Crawford JJ,Holt NL,Vallance JK,et al.A new paradigm for examining the correlates of aerobic,strength,and combined exercise:an application to gynecologic cancer survivors[J].Support Care Cancer,2016;24(8):3533-41.
15 Lysenko E,Popov D,Vepkhvadze TF,et al.Effect of combined aerobic and strength exercises on the regulation of mitochondrial biogenesis and protein synthesis and degradation in human skeletal muscle[J].Fiziol Cheloveka,2016;42(6):58-69.
16 Gratzner HG.Monoclonal antibody to 5-bromo-and 5-iododeoxyuridine:a new reagent for detection of DNA replication[J].Science,1982;218(4571):474-5.
17 Eriksson S,Kim SK,Kubista M,et al.Binding of 4',6-diamidino-2-phenylindole(DAPI)to AT regions of DNA:evidence for an allosteric conformational change[J].Biochemistry,1993;32(12):2987-98.
18 Gano LB,Patel M,Rho JM.Ketogenic diets,mitochondria,and neurological diseases[J].J Lipid Res,2014;55(11):2211-28.
19 Ogoh S,Ainslie PN.Cerebral blood flow during exercise:mechanisms of regulation[J].J Appl Physiol,2009;107(5):1370-80.
2 Bj9rklund A,Lindvall O.Self-repair in the brain[J].Nature,2000;405(6789):892-3,895.
3 Ming GL,Song H.Adult neurogenesis in the mammalian brain:significant answers and significant questions[J].Neuron,2011;70(4):687-702.
4 Altman J,Das GD.Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats[J].J Comp Neurol,1965;124(3):319-35.
5 Lazarov O,Marr RA.Neurogenesis and Alzheimer's disease:at the crossroads[J].Exp Neurol,2009;223(2):267-81.
6 Pereira AC,Huddleston DE,Brickman AM,et al.An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus[J].Proc Nat Acad Sci U S A,2007;104(13):5638-43.
7 Hamer M,Chida Y.Physical activity and risk of neurodegenerative disease:a systematic review of prospective evidence[J].Psychol Med,2009;39(1):3-11.
8 Smith PJ,Blumenthal JA,Hoffman BM,et al.Aerobic exercise and neurocognitive performance:a meta-analytic review of randomized controlled trials[J].Psychosom Med,2010;72(3):239-52.
9 Snyder JS,Cahill SP,Frankland PW.Running promotes spatial bias independently of adult neurogenesis[J].Hippocampus,2017;27(8):871-82.
10 Mastrorilli V,Scopa C,Saraulli D,et al.Physical exercise rescues defective neural stem cells and neurogenesis in the adult subventricular zone of Btg1 knockout mice[J].Brain Struct Funct,2017;222(6):2855-76.
11 于淼,蓝永生.有氧+力量混合运动预防骨质疏松的作用研究[J].科技资讯,2017;15(1):196.
12 Heck H,Mader A,Hess G,et al.Justification of the 4-mmol/L lactate threshold[J].Int J Sports Med,1985;6(3):117-30.
13 Tomas-Carus P,Ortega-Alonso A,Pietilinen K,et al.A randomized controlled trial on the effects of combined aerobic-resistance exercise on muscle strength and fatigue,glycemic control and health-related quality of life of type 2 diabetes patients[J].J Sports Med Phys Fitness,2016;56(5):572-8.
14 Crawford JJ,Holt NL,Vallance JK,et al.A new paradigm for examining the correlates of aerobic,strength,and combined exercise:an application to gynecologic cancer survivors[J].Support Care Cancer,2016;24(8):3533-41.
15 Lysenko E,Popov D,Vepkhvadze TF,et al.Effect of combined aerobic and strength exercises on the regulation of mitochondrial biogenesis and protein synthesis and degradation in human skeletal muscle[J].Fiziol Cheloveka,2016;42(6):58-69.
16 Gratzner HG.Monoclonal antibody to 5-bromo-and 5-iododeoxyuridine:a new reagent for detection of DNA replication[J].Science,1982;218(4571):474-5.
17 Eriksson S,Kim SK,Kubista M,et al.Binding of 4',6-diamidino-2-phenylindole(DAPI)to AT regions of DNA:evidence for an allosteric conformational change[J].Biochemistry,1993;32(12):2987-98.
18 Gano LB,Patel M,Rho JM.Ketogenic diets,mitochondria,and neurological diseases[J].J Lipid Res,2014;55(11):2211-28.
19 Ogoh S,Ainslie PN.Cerebral blood flow during exercise:mechanisms of regulation[J].J Appl Physiol,2009;107(5):1370-80.
© 2004-2018 中国地质图书馆版权所有 京ICP备05064691号 京公网安备11010802017129号 地址：北京市海淀区学院路29号 邮编：100083 电话：办公室：(+86 10)66554848；文献借阅、咨询服务、科技查新：66554700 |