卵黄抗体的应用及纯化研究进展
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摘要
由于抗生素的滥用带来一系列环境问题,很多国家对其使用管制越来越严格,且随着科技发展,养殖业减抗无抗已逐步提上日程。卵黄抗体(immunoglobulin of yolk,IgY)因其具有无残留、不增加细菌耐药性等优点,替代抗生素的潜力巨大。文章主要介绍了IgY在人类疾病、禽病和猪病防治中的应用以及提取纯化方法研究进展。
Due to a series of environmental problems caused by the abuse of antibiotics,the use of the drug in many countries is becoming more and more stringent. And with the development of science and technology,the use of reduced or no antibiotics in breeding industry has been gradually put on the agenda. The Immunoglobulin of yolk( IgY) has great potential to replace antibiotics because of its advantages of no residue and no increase the bacterial resistance. In this paper,the application of IgY in the prevention and treatment of human diseases,poultry diseases and pig diseases is mainly introduced. In addition,the research progress of extraction and purification methods of IgY is also discussed.
Due to a series of environmental problems caused by the abuse of antibiotics,the use of the drug in many countries is becoming more and more stringent. And with the development of science and technology,the use of reduced or no antibiotics in breeding industry has been gradually put on the agenda. The Immunoglobulin of yolk( IgY) has great potential to replace antibiotics because of its advantages of no residue and no increase the bacterial resistance. In this paper,the application of IgY in the prevention and treatment of human diseases,poultry diseases and pig diseases is mainly introduced. In addition,the research progress of extraction and purification methods of IgY is also discussed.
引文
[1]LEE C H,LEE Y C,LEU S J,et al.Production and characterization of neutralizing antibodies against bungarus multicinctus snake venom[J].Appl Environ Microbiol,2016,23.
[2]YANG Y H,PARK D,YANG G,et al.Anti-Helicobacter pylori effects of Ig Y from egg york of immunized hens[J].Lab Anim Res,2012,28(1):55-60.
[3]贺时飞,张颖,贺建军.抗轮状病毒鸡卵黄免疫球蛋白治疗小儿轮状病毒肠炎临床观察[J].儿科药学杂志,2016,22(6):26-29.
[4]龙中儿,钟青萍,朱跃科,等.抗轮状病毒卵黄免疫球蛋白的蛋白酶水解及被动免疫保护作用[J].中华实验和临床病毒学杂志,1997(4):358-362.
[5]VALILLANT A A J,AKPAKA P E,MCFARLANT-ANDERSON N,et al.The chicken and egg system for the development of antiidiotypic vaccines[J].J Vaccines Vaccin,2012,3(2):1-4.
[6]李建.新城疫和禽流感精制卵黄抗体的制备及其应用研究[D].泰安:山东农业大学,2013.
[7]张桂枝,靳双星.抗鸡新城疫和传染性法氏囊病二联卵黄抗体的研制及应用[J].中国畜牧兽医,2009,36(8):136-137.
[8]MOHAMED M I,MAARY K S,DAWOUD T M,et al.Production and evaluation of the immuno-protective efficacy of the immunoglobulins Ig Y-antibodies prepared against infectious bursal disease[J].Int J Pharmacol,2016,12(7):749-753.
[9]YOUSIF A A,MOHAMMAD W A,KHODEIR M H,et al.Oral administration of hyperimmune Ig Y:an immunoecological approach to curbing acute infectious bursal disease virus infection[J].Egypt J Immunol,2006,13(2):85.
[10]王昕,李然栋,张艳平.抗强毒新城疫、禽流感(H5、H9)多价二联高免卵黄抗体的研制和应用[J].中国动物检疫,2004,21(5):28-30.
[11]藏玉婷,王彬,宋扬,等.小鹅瘟病毒卵黄抗体田间试验[J].中国动物保健,2017,19(2):76-78.
[12]李宇琴.鸭肝炎病毒分离株的鉴定及其卵黄抗体的制备[D].扬州:扬州大学,2010.
[13]王继练,张焕容,王栋.基因A型和C型鸭甲型肝炎病毒卵黄抗体的研制及应用[J].动物医学进展,2016,37(9):43-48.
[14]李玉峰,马秀丽,于可响,等.一种从鸭新分离的黄病毒研究初报[J].畜牧兽医学报,2011,42(6):885-891.
[15]胡紫霞,王汉清,王立,等.抗鸭坦布苏病毒病卵黄抗体的制备及应用试验[J].中国动物检疫,2013,30(7):49-51.
[16]YOKOYAMA H,PERALTA R C,DIAZ R,et al.Passive protective effect of chicken egg yolk immunoglobulins against experimental enterotoxigenic Escherichia coli infection in neonatal piglets[J].Infect Immun,1992,60(3):988-1007.
[17]ZUO Y,FAN J,FAN H,et al.Prophylactic and therapeutic effects of egg yolk immunoglobulin against porcine transmissible gastroenteritis virus in piglets[J].Front Agric China,2009,3(1):104-108.
[18]李冰,张显浩,裴仉福.抗猪流行性腹泻病毒卵黄抗体的制备及应用[J].中国畜牧兽医,2014,41(10):68-72.
[19]崔焕忠,姜海龙,张加力,等.抗猪传染性胃肠炎病毒与猪流行性腹泻病毒卵黄抗体制备及其临床应用研究[J].中国畜牧兽医,2012,39(6):173-175.
[20]VEGA C G,MARINA B,VLASOVA A N,et al.Ig Y antibodies protect against human rotavirus induced diarrhea in the neonatal gnotobiotic piglet disease model[J].PLo S One,2012,7(8):e42788.
[21]许银平.抗猪圆环病毒2型卵黄抗体的研制及效果的研究[D].武汉:华中农业大学,2011.
[22]索江华,吴玉臣,唐光武.猪圆环病毒2型高免卵黄抗体的研制与应用[J].中国畜牧兽医,2010,37(6):185-187.
[23]高睿,程一肃,邓留坤,等.猪蓝耳病卵黄抗体的制备与初步应用试验[J].畜牧与饲料科学,2012,33(7):108-110.
[24]白静,任敏.抗猪瘟高免卵黄抗体的制备[J].郑州牧业工程高等专科学校学报,2006,21(1):41.
[25]李建鑫.猪瘟高免卵黄抗体的研制试验[J].中国猪业,2009(7):40-41.
[26]POLSON A,VON WECHMAR M B,VAN REGENMORTEL M H.Isolation of viral Ig Y antibodies from yolks of immunized hens[J].Immunol Commun,1980,9(5):475-493.
[27]POLSON A,COETZER T,KRUGER J,et al.Improvements in the isolation of Ig Y from the yolks of eggs laid by immunized hens[J].Immunol Invest,1985,14(4):323-327.
[28]POLSON A.Isolation of Ig Y from the yolks of eggs by a chloroform polyethylene glycol procedure[J].Immunol Invest,2009,19(3):253.
[29]JENSENIUS J C,ANDERSEN I,HAU J,et al.Eggs:conveniently packaged antibodies methods for purification of yolk Ig G[J].J Immunol Methods,1981,46(1):63-68.
[30]AKITA E M,NAKAI S.Comparison of four purification methods for the production of immunoglobulins from eggs laid by hens immunized with an enterotoxigenic E.coli strain[J].J Immunol Methods,1993,160(2):207-214.
[31]张伦,高轩,李明义.泊洛沙姆-辛酸法对鸡卵黄脱脂条件的研究[J].中国动物检疫,2011,28(3):49-51.
[2]YANG Y H,PARK D,YANG G,et al.Anti-Helicobacter pylori effects of Ig Y from egg york of immunized hens[J].Lab Anim Res,2012,28(1):55-60.
[3]贺时飞,张颖,贺建军.抗轮状病毒鸡卵黄免疫球蛋白治疗小儿轮状病毒肠炎临床观察[J].儿科药学杂志,2016,22(6):26-29.
[4]龙中儿,钟青萍,朱跃科,等.抗轮状病毒卵黄免疫球蛋白的蛋白酶水解及被动免疫保护作用[J].中华实验和临床病毒学杂志,1997(4):358-362.
[5]VALILLANT A A J,AKPAKA P E,MCFARLANT-ANDERSON N,et al.The chicken and egg system for the development of antiidiotypic vaccines[J].J Vaccines Vaccin,2012,3(2):1-4.
[6]李建.新城疫和禽流感精制卵黄抗体的制备及其应用研究[D].泰安:山东农业大学,2013.
[7]张桂枝,靳双星.抗鸡新城疫和传染性法氏囊病二联卵黄抗体的研制及应用[J].中国畜牧兽医,2009,36(8):136-137.
[8]MOHAMED M I,MAARY K S,DAWOUD T M,et al.Production and evaluation of the immuno-protective efficacy of the immunoglobulins Ig Y-antibodies prepared against infectious bursal disease[J].Int J Pharmacol,2016,12(7):749-753.
[9]YOUSIF A A,MOHAMMAD W A,KHODEIR M H,et al.Oral administration of hyperimmune Ig Y:an immunoecological approach to curbing acute infectious bursal disease virus infection[J].Egypt J Immunol,2006,13(2):85.
[10]王昕,李然栋,张艳平.抗强毒新城疫、禽流感(H5、H9)多价二联高免卵黄抗体的研制和应用[J].中国动物检疫,2004,21(5):28-30.
[11]藏玉婷,王彬,宋扬,等.小鹅瘟病毒卵黄抗体田间试验[J].中国动物保健,2017,19(2):76-78.
[12]李宇琴.鸭肝炎病毒分离株的鉴定及其卵黄抗体的制备[D].扬州:扬州大学,2010.
[13]王继练,张焕容,王栋.基因A型和C型鸭甲型肝炎病毒卵黄抗体的研制及应用[J].动物医学进展,2016,37(9):43-48.
[14]李玉峰,马秀丽,于可响,等.一种从鸭新分离的黄病毒研究初报[J].畜牧兽医学报,2011,42(6):885-891.
[15]胡紫霞,王汉清,王立,等.抗鸭坦布苏病毒病卵黄抗体的制备及应用试验[J].中国动物检疫,2013,30(7):49-51.
[16]YOKOYAMA H,PERALTA R C,DIAZ R,et al.Passive protective effect of chicken egg yolk immunoglobulins against experimental enterotoxigenic Escherichia coli infection in neonatal piglets[J].Infect Immun,1992,60(3):988-1007.
[17]ZUO Y,FAN J,FAN H,et al.Prophylactic and therapeutic effects of egg yolk immunoglobulin against porcine transmissible gastroenteritis virus in piglets[J].Front Agric China,2009,3(1):104-108.
[18]李冰,张显浩,裴仉福.抗猪流行性腹泻病毒卵黄抗体的制备及应用[J].中国畜牧兽医,2014,41(10):68-72.
[19]崔焕忠,姜海龙,张加力,等.抗猪传染性胃肠炎病毒与猪流行性腹泻病毒卵黄抗体制备及其临床应用研究[J].中国畜牧兽医,2012,39(6):173-175.
[20]VEGA C G,MARINA B,VLASOVA A N,et al.Ig Y antibodies protect against human rotavirus induced diarrhea in the neonatal gnotobiotic piglet disease model[J].PLo S One,2012,7(8):e42788.
[21]许银平.抗猪圆环病毒2型卵黄抗体的研制及效果的研究[D].武汉:华中农业大学,2011.
[22]索江华,吴玉臣,唐光武.猪圆环病毒2型高免卵黄抗体的研制与应用[J].中国畜牧兽医,2010,37(6):185-187.
[23]高睿,程一肃,邓留坤,等.猪蓝耳病卵黄抗体的制备与初步应用试验[J].畜牧与饲料科学,2012,33(7):108-110.
[24]白静,任敏.抗猪瘟高免卵黄抗体的制备[J].郑州牧业工程高等专科学校学报,2006,21(1):41.
[25]李建鑫.猪瘟高免卵黄抗体的研制试验[J].中国猪业,2009(7):40-41.
[26]POLSON A,VON WECHMAR M B,VAN REGENMORTEL M H.Isolation of viral Ig Y antibodies from yolks of immunized hens[J].Immunol Commun,1980,9(5):475-493.
[27]POLSON A,COETZER T,KRUGER J,et al.Improvements in the isolation of Ig Y from the yolks of eggs laid by immunized hens[J].Immunol Invest,1985,14(4):323-327.
[28]POLSON A.Isolation of Ig Y from the yolks of eggs by a chloroform polyethylene glycol procedure[J].Immunol Invest,2009,19(3):253.
[29]JENSENIUS J C,ANDERSEN I,HAU J,et al.Eggs:conveniently packaged antibodies methods for purification of yolk Ig G[J].J Immunol Methods,1981,46(1):63-68.
[30]AKITA E M,NAKAI S.Comparison of four purification methods for the production of immunoglobulins from eggs laid by hens immunized with an enterotoxigenic E.coli strain[J].J Immunol Methods,1993,160(2):207-214.
[31]张伦,高轩,李明义.泊洛沙姆-辛酸法对鸡卵黄脱脂条件的研究[J].中国动物检疫,2011,28(3):49-51.
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