慢性乙型肝炎患者HBeAg阳性表达、HBVDNA载量与CXCL8及其受体CXCR1阳性表达、肝功能的相关性分析

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英文篇名：Correlation Analysis between HBeAg Positive Expression and HBV DNA Load with CXCL8 and Its Receptor CXCR1 Positive Expressions and Liver Function in Patients with Chronichepatitisb 作者：曹莉 ; 王秋平 ; 赵水军 ; 袁悦 英文作者：CAO Li;WANG Qiu-ping;ZHAO Shui-jun;YUAN Yue;Department of Infection Control,463 Hospital of PLA; 关键词：乙型肝炎 ; 慢性 ; HBeAg ; 乙型肝炎病毒DNA ; CXCL8 ; CXCR1 ; 肝功能 英文关键词：Hepatitis B,chronic;;HBeAg;;Hepatitis B virus DNA;;CXCL8;;CXCR1;;Liver function 中文刊名：LCWZ 英文刊名：Clinical Misdiagnosis & Mistherapy 机构：解放军463医院感染控制科; 出版日期：2018-02-22 出版单位：临床误诊误治 年：2018 期：v.31;No.270 基金：辽宁省科技惠民计划专项资助项目(2013GS210102) 语种：中文; 页：LCWZ201802025 页数：4 CN：02 ISSN：13-1105/R 分类号：89-92

摘要

目的探讨慢性乙型肝炎患者HBeAg阳性表达、乙型肝炎病毒(HBV)DNA载量与CXCL8及其受体CXCR1阳性表达、肝功能相关性。方法选取慢性乙型肝炎100例,根据HBV DNA载量不同将其分为HBV DNA<2000 U/ml组(42例)和HBV DNA≥2000 U/ml组(58例)两组。比较不同HBV DNA载量慢性乙型肝炎患者HBeAg、CXCL8及其受体CXCR1阳性表达情况和肝功能情况,分析慢性乙型肝炎患者HBeAg阳性表达、HBV DNA载量与CXCL8及其受体CXCR1阳性表达、肝功能相关性。结果 HBV DNA≥2000 U/ml组HBeAg、CXCL8及其受体CXCR1阳性表达率和丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、直接胆红素(DBIL)、总胆红素(TBIL)水平均高于HBV DNA<2000 U/ml组,差异具有统计学意义(P<0.05)。相关性分析显示,慢性乙型肝炎患者HBeAg阳性表达率、HBV DNA载量均与CXCL8阳性表达率、CXCR1阳性表达率、ALT、AST、DBIL和TBIL水平呈正相关。结论慢性乙型肝炎患者HBeAg阳性表达率、HBV DNA载量与CXCL8及其受体CXCR1阳性表达率、肝功能密切相关。
        Objective To investigate correlations between HBeAg positive expression and hepatitis b virus( HBV)DNA load with CXCL8 and its receptor CXCR1 positive expressions and liver function in patients with chronicheoatitisb. Methods A total of 100 patients with chronic hepatitis B were divided into group A( n = 42,HBV DNA < 2000 U/ml) and group B( n =58,HBV DNA≥2000 U/ml) according to different HBV DNA loads. Positive expressions of HBeAg,CXCL8 and its receptor CXCR1 and liver function conditions in chronic hepatitis B patients with different HBV DNA loads were compared,and correlations between HBeAg positive expression and HBV DNA load with CXCL8 and its receptor CXCR1 positive expressions and liver function conditions in patients with chronic hepatitis B were analyzed. Results In group B,positive rates of HBeAg,CXCL8 and its receptor CXCR1,alanine transarninase( ALT),aspartate transaminase( AST),direct bilirubin( DBIL) and total bilirubin( TBIL) levels were significantly higher than those in group A( P < 0. 05). Correlation analysis showed that HBeAg positive expression rate and HBV DNA load were positively correlated with CXCL8 and its receptor CXCR1 positive rates,ALT,AST,DBIL and TBIL levels in patients with chronic hepatitis B. Conclusion HBeAg positive expression rate and HBV DNA load are closely correlated with CXCL8 and its receptor CXCR1 positive expression rates and liver function.

引文

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