Mass spectrometry-based proteomic approaches to study pathogenic bacteria-host interactions

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• 作者：Yufei Yang (1)
  Mo Hu (1)
  Kaiwen Yu (1)
  Xiangmei Zeng (1)
  Xiaoyun Liu (1)
  
  1. Institute of Analytical Chemistry and Synthetic and Functional Biomolecules Center ; College of Chemistry and Molecular Engineering ; Peking University ; Beijing ; 100871 ; China
  
• 关键词：mass spectrometry ; proteomics ; bacterial infection ; host ; pathogen interactions
• 刊名：Protein & Cell
• 出版年：2015
• 出版时间：April 2015
• 年：2015
• 卷：6
• 期：4
• 页码：265-274
• 全文大小：428 KB
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• 刊物主题：Biochemistry, general; Protein Science; Cell Biology; Stem Cells; Human Genetics; Developmental Biology;
• 出版者：Springer Berlin Heidelberg
• ISSN：1674-8018

文摘

Elucidation of molecular mechanisms underlying host-pathogen interactions is important for control and treatment of infectious diseases worldwide. Within the last decade, mass spectrometry (MS)-based proteomics has become a powerful and effective approach to better understand complex and dynamic host-pathogen interactions at the protein level. Herein we will review the recent progress in proteomic analyses towards bacterial infection of their mammalian host with a particular focus on enteric pathogens. Large-scale studies of dynamic proteomic alterations during infection will be discussed from the perspective of both pathogenic bacteria and host cells.