Neuroprotective Effect of Biatractylenolide Against Memory Impairment in d-Galactose-induced Aging Mice

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• 作者：Zhi-Hong Ji (1)
  Chao Liu (1)
  Hong Zhao (2)
  Xin-Yu Yu (1)
  
  1. Laboratory of Neuroscience ; College of Medicine ; Dalian University ; Dalian ; 116622 ; People鈥檚 Republic of China
  2. Department of Traditional Chinese Medicine ; College of Medicine ; Dalian University ; Dalian ; 116622 ; People鈥檚 Republic of China
  
• 关键词：Biatractylenolide ; d ; Galactose ; Aging ; Memory impairment
• 刊名：Journal of Molecular Neuroscience
• 出版年：2015
• 出版时间：March 2015
• 年：2015
• 卷：55
• 期：3
• 页码：678-683
• 全文大小：492 KB
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• 刊物主题：Neurosciences; Neurochemistry; Cell Biology; Proteomics; Neurology;
• 出版者：Springer US
• ISSN：1559-1166

文摘

Biatractylenolide, a sesquiterpene lactone, which exerted the neuroprotective effect against glutamate-induced excitotoxicity, was isolated from Atractylodis macrocephala in our previous study. In this study, we evaluated the neuroprotective effect of biatractylenolide against d-galactose-induced memory impairment and explored the potential mechanism of its action. The results showed that administration of biatractylenolide could significantly improve behavioral performance of d-galactose-treated mice in passive avoidance test and spatial learning-memory test. Administration of biatractylenolide could significantly decrease the formation of reactive oxygen species (ROS), decrease the activity of acetylcholinesterase (AChE), and increase the expression of synapsin I and protein kinase C (PKC) in d-galactose-treated mice. Our findings provide first evidence for the neuroprotective effect of biatractylenolide against d-galactose-induced memory impairment. The potential mechanisms underlying the neuroprotective effect of biatractylenolide in d-galactose-treated mice might be (i) attenuating oxidative damage via decreasing ROS formation, (ii) restoring cholinergic neurotransmission via decreasing AChE activity, and (iii) increasing the expression of memory-related proteins (synapsin I and PKC). Biatractylenolide may have therapeutic potential in aging-related memory impairment.