Copper-Catalyzed P–H Insertions of α-Imino Carbenes for the Preparation of 3-Phosphinoylindoles

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• 作者：Lisheng Wang ; Yi Wu ; Yang Liu ; Hua Yang ; Xu Liu ; Jianyi Wang ; Xiaoxun Li ; Jun Jiang
• 刊名：Organic Letters
• 出版年：2017
• 出版时间：February 17, 2017
• 年：2017
• 卷：19
• 期：4
• 页码：782-785
• 全文大小：437K
• ISSN：1523-7052

文摘

A highly efficient P–H insertion of α-imino copper carbene into H-phosphine oxides, leading to 3-phosphinoylindoles with a broad substrate diversity and good chemoselectivity, is established. This methodology provides a rapid and efficient approach for the C (sp²)–P bond formation via the P–H insertion strategy. The stereoselective P–H insertion of α-imino copper carbene represents a unique example of asymmetric P–H insertion, affording P-stereogenic 3-phosphinoylindoles with high stereoselectivities.