Synthesis of 3-Fluoroindoles via Photoredox Catalysis

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• 作者：Liubov I. Panferova ; Vladimir O. Smirnov ; Vitalij V. Levin ; Vladimir A. Kokorekin ; Marina I. Struchkova ; Alexander D. Dilman
• 刊名：Journal of Organic Chemistry
• 出版年：2017
• 出版时间：January 6, 2017
• 年：2017
• 卷：82
• 期：1
• 页码：745-753
• 全文大小：626K
• ISSN：1520-6904

文摘

A method for the synthesis of 3-fluoroindoles from N-arylamines substituted with the CF₂I group is described. The reaction is mediated by a ruthenium photocatalyst in the presence of a substoichiometric amount of triphenylphosphine upon irradiation with blue light. The starting N-arylamines are readily obtained by nucleophilic iododifluoromethylation of iminium ions.