Adherence to a Mediterranean Diet Influences the Fecal Metabolic Profile of Microbial-Derived Phenolics in a Spanish Cohort of Middle-Age and Older People

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• 作者：Isabel Gutiérrez-Díaz ; Tania Fernández-Navarro ; Nuria Salazar ; Begoña Bartolomé ; M. Victoria Moreno-ArribasEnrique Juan de Andres-Galiana ; Juan Luis Fernández-Martínez ; Clara G. de los Reyes-Gavilán ; Miguel Gueimonde ; Sonia González
• 刊名：Journal of Agricultural and Food Chemistry
• 出版年：2017
• 出版时间：January 25, 2017
• 年：2017
• 卷：65
• 期：3
• 页码：586-595
• 全文大小：424K
• ISSN：1520-5118

文摘

Despite the evidence regarding the influence of certain polyphenol food sources on the metabolic profile in feces, the association between the different phenolics provided by the diet and the fecal phenolic profile has not been elucidated. In this study, the composition of phenolic metabolites in fecal solutions was analyzed by UPLC-ESI-MS/MS in 74 volunteers. This fecal phenolic profile showed a high interindividual variation of the different compounds analyzed, phenylacetic and phenylpropionic acids being the major classes of phenolic metabolites excreted in feces. Subjects with higher adherence to a Mediterranean dietary pattern presented greater fecal concentrations of benzoic and 3-hydroxyphenylacetic acids, positively correlated with the intake of the principal classes and subclasses of polyphenols and fibers, and higher levels of Clostridium cluster XVIa and Faecalibacterium prausnitzii. These results provide a link among the Mediterranean dietary pattern, the bioactive compounds of the diet, and the fecal metabolic phenolic profile.