Superparamagnetic Nanoparticles as High Efficiency Magnetic Resonance Imaging T2 Contrast Agent

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• 作者：Fernanda Sousa ; Barbara SanavioAlessandra Saccani ; Yun Tang ; Ileana Zucca ; Tamara M. Carney ; Alfonso Mastropietro ; Paulo H. Jacob Silva ; Randy P. Carney ; Kurt Schenk ; Arash O. Omrani ; Ping Huang ; Lin Yang ; Henrik M. Rønnow ; Francesco Stellacci ; Silke Krol
• 刊名：Bioconjugate Chemistry
• 出版年：2017
• 出版时间：January 18, 2017
• 年：2017
• 卷：28
• 期：1
• 页码：161-170
• 全文大小：587K
• ISSN：1520-4812

文摘

Nanoparticle-based magnetic resonance imaging T₂ negative agents are of great interest, and much effort is devoted to increasing cell-loading capability while maintaining low cytotoxicity. Herein, two classes of mixed-ligand protected magnetic-responsive, bimetallic gold/iron nanoparticles (Au/Fe NPs) synthesized by a two-step method are presented. Their structure, surface composition, and magnetic properties are characterized. The two classes of sulfonated Au/Fe NPs, with an average diameter of 4 nm, have an average atomic ratio of Au to Fe equal to 7 or 8, which enables the Au/Fe NPs to be superparamagnetic with a blocking temperature of 56 K and 96 K. Furthermore, preliminary cellular studies reveal that both Au/Fe NPs show very limited toxicity. MRI phantom experiments show that r₂/r₁ ratio of Au/Fe NPs is as high as 670, leading to a 66% reduction in T₂ relaxation time. These nanoparticles provide great versatility and potential for nanoparticle-based diagnostics and therapeutic applications and as imaging contrast agents.