Steering Carbon Nanotubes to Scavenger Receptor Recognition by Nanotube Surface Chemistry Modification Partially Alleviates NFκB Activation and Reduces Its Immunotoxicity

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• 作者：Ningning Gao ; Qiu Zhang ; Qingxin Mu ; Yuhong Bai ; Liwen Li ; Hongyu Zhou ; Elizabeth R. Butch ; Tremaine B. Powell ; Scott E. Snyder ; Guibin Jiang ; Bing Yan
• 刊名：ACS Nano
• 出版年：2011
• 出版时间：June 28, 2011
• 年：2011
• 卷：5
• 期：6
• 页码：4581-4591
• 全文大小：1245K
• 年卷期：0
• ISSN：1936-086X

文摘

Carbon nanotubes (CNTs) cause perturbations in immune systems and limit the application of CNTs in biomedicine. Here we demonstrate that a surface chemistry modification on multiwalled CNTs (MWCNTs) reduces their immune perturbations in mice and in macrophages. The modified MWCNTs change their preferred binding pattern from mannose receptor to scavenger receptor. This switch significantly alleviates NFκB activation and reduces immunotoxicity of MWCNTs.