Growth-Factor Nanocapsules That Enable Tunable Controlled Release for Bone Regeneration

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• 作者：Haijun Tian ; Juanjuan Du ; Jing Wen ; Yang Liu ; Scott R. Montgomery ; Trevor P. Scott ; Bayan Aghdasi ; Chengjie Xiong ; Akinobu Suzuki ; Tetsuo Hayashi ; Monchai Ruangchainikom ; Kevin Phan ; Gil Weintraub ; Alobaidaan Raed ; Samuel S. Murray ; Michael D. Daubs ; Xianjin Yang ; Xu-bo Yuan ; Jeffrey C. Wang ; Yunfeng Lu
• 刊名：ACS Nano
• 出版年：2016
• 出版时间：August 23, 2016
• 年：2016
• 卷：10
• 期：8
• 页码：7362-7369
• 全文大小：466K
• 年卷期：0
• ISSN：1936-086X

文摘

Growth factors are of great potential in regenerative medicine. However, their clinical applications are largely limited by the short in vivo half-lives and the narrow therapeutic window. Thus, a robust controlled release system remains an unmet medical need for growth-factor-based therapies. In this research, a nanoscale controlled release system (degradable protein nanocapsule) is established via in situ polymerization on growth factor. The release rate can be finely tuned by engineering the surface polymer composition. Improved therapeutic outcomes can be achieved with growth factor nanocapsules, as illustrated in spinal cord fusion mediated by bone morphogenetic protein-2 nanocapsules.