Iridium Catalysts with f-Amphox Ligands: Asymmetric Hydrogenation of Simple Ketones

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• 作者：Weilong Wu ; Shaodong Liu ; Meng Duan ; Xuefeng Tan ; Caiyou Chen ; Yun Xie ; Yu Lan ; Xiu-Qin Dong ; Xumu Zhang
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：June 17, 2016
• 年：2016
• 卷：18
• 期：12
• 页码：2938-2941
• 全文大小：390K
• 年卷期：0
• ISSN：1523-7052

文摘

A series of modular and rich electronic tridentate ferrocene aminophosphoxazoline ligands (f-amphox) have been successfully developed and used in iridium-catalytic asymmetric hydrogenation of simple ketones to afford corresponding enantiomerically enriched alcohols under mild conditions with superb activities and excellent enantioselectivities (up to 1 000 000 TON, almost all products up to >99% ee, full conversion). The resulting chiral alcohols and their derivatives are important intermediates in pharmaceuticals.