(±)-Japonicols A–D, Acylphloroglucinol-Based Meroterpenoid Enantiomers with Anti-KSHV Activities from Hypericum japonicum

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• 作者：Linzhen Hu ; Yongbo Xue ; Jinwen Zhang ; Hucheng Zhu ; Chunmei Chen ; Xiao-Nian Li ; Junjun Liu ; Zhenzhen Wang ; Yu Zhang ; Yonghui Zhang
• 刊名：Journal of Natural Products
• 出版年：2016
• 出版时间：May 27, 2016
• 年：2016
• 卷：79
• 期：5
• 页码：1322-1328
• 全文大小：465K
• 年卷期：0
• ISSN：1520-6025

文摘

(±)-Japonicols A–D (1a/1b–4a/4b), four pairs of new phloroglucinol-based terpenoid enantiomers, were isolated from Hypericum japonicum. Their absolute configurations were confirmed through comparison of their experimental and calculated electronic circular dichroism spectra and single-crystal X-ray diffraction analyses. Compounds 1a/1b, 2a/2b, and 3a/3b possess 2-oxabicyclo[3.3.1]nonane, pyrano[3,2-b]pyran, and benzo[b]cyclopenta[e]oxepine ring systems, respectively. The effects of the phloroglucinols on anti-Kaposi’s sarcoma-associated herpesvirus were assessed, and 2a exhibited a moderate inhibitory effect, with an EC₅₀ value of 8.75 μM and a selectivity index of 16.06.