Self-Assembly of Fluorescent Organic Nanoparticles for Iron(III) Sensing and Cellular Imaging

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• 作者：Yu Yang ; Xiaoyu Wang ; Qianling Cui ; Qian Cao ; Lidong Li
• 刊名：ACS Applied Materials & Interfaces
• 出版年：2016
• 出版时间：March 23, 2016
• 年：2016
• 卷：8
• 期：11
• 页码：7440-7448
• 全文大小：535K
• ISSN：1944-8252

文摘

Fluorescent organic nanoparticles have attracted increasing attentions for chemical or biological sensing and imaging due to their low-toxicity, facile fabrication and surface functionalization. In this work, we report novel fluorescent organic nanoparticles via facile self-assembly method in aqueous solution. First, the designed water-soluble fluorophore shows a weak and negligible intrinsic fluorescence in water. Upon binding with adenosine-5′-triphosphate (ATP), fluorescent nanoparticles were formed immediately with strongly enhanced fluorescence. These fluorescent nanoparticles exhibit high sensitivity and selectivity toward Fe³⁺ sensing with detection limit of 0.1 nM. In addition, after incubation with HeLa cells, the fluorophore shows excellent imaging performance by interaction with entogenous ATP in cells. Finally, this fluorescent system is also demonstrated to be capable of Fe³⁺ sensing via fluorescence quenching in cellular environment.