Highly Stereo- and Regioselective Hydrocarboxylation of Diynes with Carbon Dioxide

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• 作者：Tao Cao ; Shengming Ma
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：April 1, 2016
• 年：2016
• 卷：18
• 期：7
• 页码：1510-1513
• 全文大小：393K
• ISSN：1523-7052

文摘

A nickel-catalyzed three-component hydrocarboxylation of diynes with ZnEt₂ and CO₂ (1 atm) is disclosed. With this method, symmetric/nonsymmetric diynes could be reacted smoothly with very high stereo- and regioselectivity, affording conjugated 2,4-alkadienoic acids incorporated with five- or six-membered rings efficiently. A stepwise non-oxidative cyclometalation mechanism was proposed based on careful mechanistic studies.