Processing and Characterization of SrTiO3鈥揟iO2 Nanoparticle鈥揘anotube Heterostructures on Titanium for Biomedical Applications

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• 作者：Yu Wang ; Dongmei Zhang ; Cuie Wen ; Yuncang Li
• 刊名：ACS Applied Materials & Interfaces
• 出版年：2015
• 出版时间：July 29, 2015
• 年：2015
• 卷：7
• 期：29
• 页码：16018-16026
• 全文大小：566K
• ISSN：1944-8252

文摘

Surface properties such as physicochemical characteristics and topographical parameters of biomaterials, essentially determining the interaction between the biological cells and the biomaterial, are important considerations in the design of implant materials. In this study, a layer of SrTiO₃鈥揟iO₂ nanoparticle鈥搉anotube heterostructures on titanium has been fabricated via anodization combined with a hydrothermal process. Titanium was anodized to create a layer of titania (TiO₂) nanotubes (TNTs), which was then decorated with a layer of SrTiO₃ nanoparticles via hydrothermal processing. SrTiO₃鈥揟iO₂ heterostructures with high and low volume fraction of SrTiO₃ nanoparticle (denoted by 6.3-Sr/TNTs and 1.4-Sr/TNTs) were achieved by using a hydrothermal processing time of 12 and 3 h, respectively. The in vitro biocompatibility of the SrTiO₃鈥揟iO₂ heterostructures was assessed by using osteoblast cells (SaOS2). Our results indicated that the SrTiO₃鈥揟iO₂ heterostructures with different volume fractions of SrTiO₃ nanoparticles exhibited different Sr ion release in cell culture media and different surface energies. An appropriate volume fraction of SrTiO₃ in the heterostructures stimulated the secretion of cell filopodia, leading to enhanced biocompatibility in terms of cell attachment, anchoring, and proliferation on the heterostructure surface.