Intestine-Specific Delivery of Hydrophobic Bioactives from Oxidized Starch Microspheres with an Enhanced Stability

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• 作者：Shanshan Wang ; Yuying Chen ; Hao Liang ; Yiming Chen ; Mengxuan Shi ; Jiande Wu ; Xianwu Liu ; Zuseng Li ; Bin Liu ; Qipeng Yuan ; Yuan Li
• 刊名：Journal of Agricultural and Food Chemistry
• 出版年：2015
• 出版时间：October 7, 2015
• 年：2015
• 卷：63
• 期：39
• 页码：8669-8675
• 全文大小：345K
• ISSN：1520-5118

文摘

An intestine-specific delivery system for hydrophobic bioactives with improved stability was developed. It consists of oxidized potato starch polymers, where the carboxyl groups were physically cross-linked via ferric ions. The model hydrophobic ingredients (尾-carotene) were incorporated inside the starch microspheres via a double-emulsion method. Confocal laser scanning microscopy images showed that 尾-carotene were distributed homogeneously in the inner oil phase of the starch microspheres. The negative value of the 味-potential of microspheres increased with increasing pH and decreasing ionic strength. In vitro release experiments showed that the microspheres were stable at acidic stomach conditions (pH < 2), whereas at neutral intestinal conditions (pH 7.0), they rupture to release the loaded 尾-carotene. The 1,1-diphenyl-2-picrylhydrazyl radical, 2,2-diphenyl-1-(2,4,6-trinitriphenyl), scavenging activity results suggested that microsphere-encapsulated 尾-carotene had an improved activity after thermal treatment at 80 掳C. The storage stability of encapsulated 尾-carotene at room temperature was also enhanced. The starch microspheres showed potential as intestine-specific carriers with an enhanced stability.