Synthesis of Multiring Fused 2-Pyridones via a Nitrene Insertion Reaction: Fluorescent Modulators of 伪-Synuclein Amyloid Formation

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• 作者：Pardeep Singh ; Erik Chorell ; K. Syam Krishnan ; Tomas Kindahl ; J枚rgen 脜den ; Pernilla Wittung-Stafshede ; Fredrik Almqvist
• 刊名：Organic Letters
• 出版年：2015
• 出版时间：December 18, 2015
• 年：2015
• 卷：17
• 期：24
• 页码：6194-6197
• 全文大小：347K
• ISSN：1523-7052

文摘

An efficient, straightforward method for the synthesis of thiazolo-2-pyridone embedded peptidomimetic polyheterocycles via a catalyst-free, microwave-assisted, intramolecular C鈥揌 amination reaction is reported. All the synthesized polyheterocycles were evaluated for their fluorescent properties and effect on 伪-synuclein amyloid formation.