Chemopreventive Effects of (鈭?-Hinokinin against 1,2-Dimethylhydrazine-Induced Genotoxicity and Preneoplastic Lesions in Rat Colon

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• 作者：Lilian C. Barbosa ; Ricardo A. Furtado ; Humberto C. C. Bertanha ; Iara M. Tomazella ; Eveline S. Costa ; Jairo K. Bastos ; M谩rcio L. Andrade e Silva ; Denise C. Tavares
• 刊名：Journal of Natural Products
• 出版年：2014
• 出版时间：October 24, 2014
• 年：2014
• 卷：77
• 期：10
• 页码：2312-2315
• 全文大小：233K
• ISSN：1520-6025

文摘

(鈭?-Hinokinin (1) is a dibenzylbutyrolactone lignan obtained by the partial synthesis of (鈭?-cubebin. This study reports the antigenotoxic and anticarcinogenic potential of 1 by the comet and aberrant crypt focus assays in the peripheral blood and colon of 4鈥?-week-old Wistar rats, respectively. The rats were exposed to 1,2-dimethylhydrazine (40 mg/kg) and were treated by gavage with doses of 10, 20, and 40 mg/kg of 1. The results showed that the dose of 40 mg/kg was neither genotoxic nor carcinogenic. In the comet assay, all 1 doses displayed antigenotoxic effects. In addition, this compound (20 and 40 mg/kg) exhibited an anticarcinogenic effect in the aberrant crypt focus assay.